DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC39A8 and foi

DIOPT Version :9

Sequence 1:	XP_024309952.1	Gene:	SLC39A8 / 64116	HGNCID:	20862	Length:	475	Species:	Homo sapiens
Sequence 2:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	131/580 - (22%)
Similarity:	205/580 - (35%)	Gaps:	210/580 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    44 SAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEI------------FSLH----GFSNATQI 92
            |..:.:|...:.|..|...||:..|.:..:.:..:|:            .|||    |.|..|.:
  Fly    81 SRREKRHAGHEHGPTSESRVPQITQYYLEKLMAQDELMNSSGFDGLLQQLSLHSLASGASEGTCV 145

Human    93 TSSKF------------------------------------SVICPAVLQQLNFHPCEDRPKHKT 121
            ..|:.                                    :||||: |...|.||.....|:.|
  Fly   146 PGSRLVHHVQPHDHHHAHHHEEEDHSLQLNNCTLIQNGTTSNVICPS-LPNNNTHPLGKEAKNFT 209

Human   122 -------------------------RPS------------HSE-------VWGYGFLSVTIINLA 142
                                     .|:            .:|       ||.|.|:||....:.
  Fly   210 LSDKDLLHLCPILLYELKAQSGGCIEPAILSDIDTTEELLEAEKDKDIFYVWIYAFISVFACGIL 274

Human   143 SLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAF-GFDPKVDSYVEKAVAVFGGF 206
            .|:|:.:.|.:...|:..|:.:.|.||:||:..:|:..|:|.:. |.|.:  ..:.|.:...||.
  Fly   275 GLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDALLHLLPHSLAGQDER--GMIMKGLGCLGGI 337

Human   207 YLLFFFERMLKML--------------------LKTYGQNGHTHFGNDNFGPQEKTHQPKALPAI 251
            ...:..|..|.|:                    ::....:.:.....|....|:.:..|.....|
  Fly   338 IFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEI 402

Human   252 -------------------------------NGV-------------TCYANPAVT---EANGHI 269
                                           |||             ....:|..|   |.|.|.
  Fly   403 TMNNKQSEWMHLPFDVAAGAGGDAPSVAELRNGVGDHDGSNDMAAAAESLISPLHTNCVEMNHHN 467

Human   270 H-------------FDNVSVVSLQDGK--------KEPSS-----CTCLKGPKLSEIG------- 301
            |             .|:.::|:..||.        |:..|     ...|:..:.|..|
  Fly   468 HNHKHNSHQQNHEGQDSNTIVTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSHRHGH 532

Human   302 ---------TIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLN 357
                     .:||||.:.|.||||.||:||||:...::..|.|||:|:.|.|.|||||||.||:.
  Fly   533 VHSPPETLSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIK 597

Human   358 AGMSTRQALLFNFLSACSCYVGLAFGILVG-NNFAPNIIFALAGGMFLYISLADMFPEMN 416
            ||||.:.|:.:|.|:....::|:.|||..| :......:||:|.|:|:||:|.||.||::
  Fly   598 AGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQSQDVAQWMFAVAAGLFIYIALVDMMPEIS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A8	XP_024309952.1	Zip	126..422	CDD:308248	105/409 (26%)
foi	NP_001261584.1	Zip	258..684	CDD:280666	104/402 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950