DRSC/TRiP Functional Genomics Resources

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Protein Alignment BLM and SGS1

DIOPT Version :10

Sequence 1:NP_000048.1 Gene:BLM / 641 HGNCID:1058 Length:1417 Species:Homo sapiens
Sequence 2:NP_013915.1 Gene:SGS1 / 855228 SGDID:S000004802 Length:1447 Species:Saccharomyces cerevisiae


Alignment Length:1603 Identity:412/1603 - (25%)
Similarity:663/1603 - (41%) Gaps:414/1603 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDV 65
            |...|.:||     |...:.|....:|.:.|  .|.|:   :...:::.........|...:|| 
Yeast     1 MVTKPSHNL-----RREHKWLKETATLQEDK--DFVFQ---AIQKHIANKRPKTNSPPTTPSKD- 54

Human    66 NVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKK 130
                     |..|.|||      |..:.||...|.                  ..|.|:......
Yeast    55 ---------ECGPGTTN------FITSIPASGPTN------------------TATKQHEVMQTL 86

Human   131 SRDTALKKLEFSSSPDSLSTINDWDDMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFK 195
            |.||  :.|.::      :|.|.:.|:...|. ..|.|.|:.|:       |...||....|.|:
Yeast    87 SNDT--EWLSYT------ATSNQYADVPMVDI-PASTSVVSNPR-------TPNGSKTHNFNTFR 135

Human   196 AQLYTT---NTVKTDLPPPSSESEQID--------------------------LTEEQK------ 225
            ..:.::   |....:|...::....||                          |.|:.|      
Yeast   136 PHMASSLVENDSSRNLGSRNNNKSVIDNSSIGKQLENDIKLEVIRLQGSLIMALKEQSKLLLQKC 200

Human   226 --DDSEWLSSDV----ICIDDGP-IAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHST 283
              .:|..||.|.    :..|..| ::.:.|..|:.|.:.:|.    ::|...|.::...:::.| 
Yeast   201 SIIESTSLSEDAKRLQLSRDIRPQLSNMSIRIDSLEKEIIKA----KKDGMSKDQSKGRSQVSS- 260

Human   284 EKVPCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKM 348
                     .||.....:.|||.|                 .:||.|..::.||:...::|...:
Yeast   261 ---------QDDNIISSILPSPLE-----------------YNTSSRNSNLTSTTATTVTKALAI 299

Human   349 SMQELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCG---------------- 397
            :..:.|...:|..::...|....||.|::.        .||    :||.                
Yeast   300 TGAKQNITNNTGKNSNNDSNNDDLIQVLDD--------EDD----IDCDPPVILKEGAPHSPAFP 352

Human   398 ---------NELLQQRNIRRKLLTEVDFNKSDAS-----LLGSLWR-------YRPDSLDGPMEG 441
                     :||.::||:|.:  ..|::...|..     ::|...|       ...|.|....|.
Yeast   353 HLHMTSEEQDELTRRRNMRSR--EPVNYRIPDRDDPFDYVMGKSLRDDYPDVEREEDELTMEAED 415

Human   442 DS----CPTGNSMKELN-------FSHLPSNSVSP----------------------GDCLLTTT 473
            |:    ..|.:..||.|       |..:.::.:.|                      ||...|.|
Yeast   416 DAHSSYMTTRDEEKEENELLNQSDFDFVVNDDLDPTQDTDYHDNMDVSANIQESSQEGDTRSTIT 480

Human   474 LGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTA 538
            |.:      .||:           :..:||..|::.....:|:......::|.....||.....:
Yeast   481 LSQ------NKNV-----------QVILSSPTAQSVPSNGQNQIGVEHIDLLEDDLEKDAILDDS 528

Human   539 SINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLA---ASKSSTAAYQPIKEGR--------- 591
            ......|:..|....|...||...:::|:|:..:|..   .|.|....:...:|.|         
Yeast   529 MSFSFGRQHMPMSHSDLELIDSEKENEDFEEDNNNNGIEYLSDSDLERFDEERENRTQVADIQEL 593

Human   592 --PIKSVSERLSSAKTDCLP-------------VSSTAQNINFSE--SIQNYTDKSAQNLASRNL 639
              .:|.::||..:...:..|             ||...:..:|.:  |:.:...||  ||:|:. 
Yeast   594 DNDLKIITERKLTGDNEHPPPSWSPKIKREKSSVSQKDEEDDFDDDFSLSDIVSKS--NLSSKT- 655

Human   640 KHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPAC 704
                 ...::|.:.|::...|:.|.|..||.|||||:||.|.|:|.|:||||||||||||||||.
Yeast   656 -----NGPTYPWSDEVLYRLHEVFKLPGFRPNQLEAVNATLQGKDVFVLMPTGGGKSLCYQLPAV 715

Human   705 V----SPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDS---EATNIYLQLSKKDPIIKL 762
            |    :.|.|:|||||.||:.|||:.|.:.:|.|:..:...|..   :..|:::     :.::.|
Yeast   716 VKSGKTHGTTIVISPLISLMQDQVEHLLNKNIKASMFSSRGTAEQRRQTFNLFI-----NGLLDL 775

Human   763 LYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVM 827
            :|::||.|.||.:....:..||....|||.|:|||||||.||||||.|||.:...::::|.:|::
Yeast   776 VYISPEMISASEQCKRAISRLYADGKLARIVVDEAHCVSNWGHDFRPDYKELKFFKREYPDIPMI 840

Human   828 ALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGI 892
            ||||||:.:|:.||:..|::..|.....||||.|| ||.:.||.|...|:..:.::......:||
Yeast   841 ALTATASEQVRMDIIHNLELKEPVFLKQSFNRTNL-YYEVNKKTKNTIFEICDAVKSRFKNQTGI 904

Human   893 IYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPD 957
            |||.|::.|:..:..:||:|:....||||:....|..||:.| ..|..||||||:||||||||||
Yeast   905 IYCHSKKSCEQTSAQMQRNGIKCAYYHAGMEPDERLSVQKAW-QADEIQVICATVAFGMGIDKPD 968

Human   958 VRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNN 1022
            ||||.|.::|:::||||||:|||||||..|:|:.::::.|:..::.:|..:|:.:...:|.|.|.
Yeast   969 VRFVYHFTVPRTLEGYYQETGRAGRDGNYSYCITYFSFRDIRTMQTMIQKDKNLDRENKEKHLNK 1033

Human  1023 LYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDY--KTRDVTDDVKSIV 1085
            |..::.||:|:|:|||..:|:||.|: |:...|.|    :||||..:.:.  :.||||:..|.||
Yeast  1034 LQQVMAYCDNVTDCRRKLVLSYFNED-FDSKLCHK----NCDNCRNSANVINEERDVTEPAKKIV 1093

Human  1086 RFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKI---------QSGIFGKGSAYSRHN 1141
            :.|:...:.             |.|:....|:|.||:|:||         :.||   |.:..:..
Yeast  1094 KLVESIQNE-------------RVTIIYCQDVFKGSRSSKIVQANHDTLEEHGI---GKSMQKSE 1142

Human  1142 AERLFKKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKV-----------------DF 1189
            .||:|..||..::|.|...:|.:..|.:||.:|..|:.:|.|.:::                 .|
Yeast  1143 IERIFFHLITIRVLQEYSIMNNSGFASSYVKVGPNAKKLLTGKMEIKMQFTISAPNSRPSTSSSF 1207

Human  1190 METENSSSVKKQKAL-----VAK-----VSQREEMVKKCLG------------------------ 1220
            ...|::..|..||:.     ||.     :|.:|.:.....|                        
Yeast  1208 QANEDNIPVIAQKSTTIGGNVAANPPRFISAKEHLRSYTYGGSTMGSSHPITLKNTSDLRSTQEL 1272

Human  1221 --------ELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLE---KY 1274
                    .|.|:..:||........|......|||:|..|..:......: |..|||..   ||
Yeast  1273 NNLRMTYERLRELSLNLGNRMVPPVGNFMPDSILKKMAAILPMNDSAFATL-GTVEDKYRRRFKY 1336

Human  1275 GAEVISVL---------QKY-----SEWTSPAEDSSPGISLSSSR-----GPGRSAAEELDEEIP 1320
            ....|:.|         :||     .|:.:.|..||.||:.|:..     |...:.|:|.::.| 
Yeast  1337 FKATIADLSKKRSSEDHEKYDTILNDEFVNRAAASSNGIAQSTGTKSKFFGANLNEAKENEQII- 1400

Human  1321 VSSHYFASKTRNERKRKKMP---ASQRSKRRKTASSGSKAKGG 1360
                       |:.::.::|   .|.:|..|..:.|..|:..|
Yeast  1401 -----------NQIRQSQLPKNTTSSKSGTRSISKSSKKSANG 1432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BLMNP_000048.1 BLM_N 1..368 CDD:465064 75/408 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..227 6/57 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..291 6/40 (15%)
Necessary for interaction with SPIDR. /evidence=ECO:0000269|PubMed:23509288 301..600 67/382 (18%)
Necessary for dimerization and homooligomerization. /evidence=ECO:0000269|PubMed:28228481 362..414 13/76 (17%)
BDHCT 372..412 CDD:462356 12/64 (19%)
BDHCT_assoc 425..647 CDD:465065 51/290 (18%)
recQ_fam 657..1143 CDD:129701 205/503 (41%)
DEAH box 795..798 2/2 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:25901030 870..873 1/2 (50%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 897..899 1/1 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1000..1003 0/2 (0%)
DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:24257077 1094..1139 12/53 (23%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1110..1112 1/1 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1121..1125 2/3 (67%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1160..1166 1/5 (20%)
HRDC 1213..1292 CDD:128635 22/127 (17%)
Necessary for ssDNA and DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:20639533 1227..1244 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1417 18/80 (23%)
Nuclear localization signal. /evidence=ECO:0000255 1334..1349 3/17 (18%)
SGS1NP_013915.1 RecQ 670..1151 CDD:440280 208/508 (41%)
Helicase_Sgs1 1271..1350 CDD:463270 18/79 (23%)

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