back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BLM and RecQ4

DIOPT Version :10

Sequence 1:	NP_000048.1	Gene:	BLM / 641	HGNCID:	1058	Length:	1417	Species:	Homo sapiens
Sequence 2:	NP_652607.1	Gene:	RecQ4 / 53438	FlyBaseID:	FBgn0040290	Length:	1579	Species:	Drosophila melanogaster

Alignment Length:	1155	Identity:	287/1155 - (24%)
Similarity:	445/1155 - (38%)	Gaps:	272/1155 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    20 TLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQ 84
            :|:.||..|...|:....:|..|...:.|.:..|::..|...::::...|.....:.......||
  Fly   204 SLSAKLFQSSRGFAKRNPRKPLSRCVSSSSSTTSLSSVPTDHHEELLDFETILIRKAQEYKEKQQ 268

Human    85 RVKDFFKNAPAGQETQRGGSKSLLPD--FLQTPKEVVC--------TTQNTPTVKKSR----DTA 135
            .:.:   |.....|..:...|:|:.|  ..:..||...        ...|:.|.||:.    :..
  Fly   269 AIAN---NPMLASEHSKESIKTLVDDGWLRRNTKENTLDEEVPFAEANNNSGTSKKTNFGLANLD 330

Human   136 LKKLE--------FSSSPDSLSTINDWD-DMDDFDTSETSKSFVTPPQSHFVRVSTAQKSKKGKR 191
            |.||:        ..:.||.::.|.:.. ||:.....:......|||.|.  :.|.|.|:|
  Fly   331 LSKLKPTVKEEKVLQAKPDQMAIIQELQTDMNSSMNQKPDHLNHTPPASS--QKSVAPKNK---- 389

Human   192 NFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESD 256
                             ||||          ||:.||:         .|..:||   :|:.||.
  Fly   390 -----------------PPPS----------EQETDSD---------SDSVVAE---SEEEQEP- 414

Human   257 SLKTHLEDERDNSEKKKNLEEA----ELHSTEKVP-CIEFD-------------DDDYDTDFVPP 303
                  ::.|..|:::|.:..|    |:.:..::| .:|.:             |:|.|..:||.
  Fly   415 ------QEYRQLSKRRKIVSTASGKVEVAAPVEIPNKVEPETETFAQENPDFSADEDQDATYVPE 473

Human   304 SPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDC------- 361
            :.::     ..:.:..:..|...|..:.|....|.|....|.||....|..|..|...
  Fly   474 NKKK-----DKAKRKQAAGKQKTTKPKAEPKPKTEKKAKVKAEKKPKAEKKPRNSKKAIAVEPAP 533

Human   362 ----DARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQ----------------RNI 406
                |.||....:.|.:|:......|.::|...::.|:..:...|:                .||
  Fly   534 DPEEDERQPLNPEDLKYVLALEAGDITSVPRINVQDLEEADATAQRYIRTFAAGPNPGLSEGSNI 598

Human   407 R--------RKLLTE---------------------------VDFNKSDASLLGSLWRY--RPDS 434
            |        ||.|.|                           |:|:|...    ..||:  |..:
  Fly   599 RVDEKRAAARKKLEERIAAGKLNENFVTINIQKKKFVRGKKSVNFSKYKK----QQWRHKKRVAA 659

Human   435 LDGP-MEGDSCPTG--NSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPL-FNTH 495
            |.|| |:...|..|  ...:.....|........||.||..:          ..|.|.|. |.|.
  Fly   660 LSGPDMDMGGCDGGVLTCFQCGGVGHFAQQCKVKGDSLLPLS----------AQLEEDPSPFPTL 714

Human   496 LQKSFVSSNWA------ETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDID 554
            .:...::|..|      ...||.:...::...|:.|..:...||  .::...::::...|::..|
  Fly   715 AEAQEMASQGAVVAHSRNISRLPQAANAAILQGDELNESEEDDQ--ESSGDEEVQQHPDPNWSSD 777

Human   555 NFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPI---KEGRPIKSV------SERLSSAKTDCLPV 610
            ..|: ||:..|         ||.::|.:  ||:   |...|||:.      .|.|..|..|
  Fly   778 EMDV-DFEALD---------AAVEASLS--QPVSQEKAASPIKTYVGHKIPEEFLKQAGLD---- 826

Human   611 SSTAQNINFSES------IQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFR 669
             :||.:.|.|:.      .....|.|.|:.                 |.|:::..| .||..|||
  Fly   827 -TTASSSNRSQHGGVKPLYDLLPDGSVQDT-----------------TPEVLEALH-MFGHTNFR 872

Human   670 TNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSP----GVTVVISPLRSLIVDQVQKLTSL 730
            ..|..||...|.|....:.:.||.||||||||||.:..    .:|:|||||.||:.|||..:...
  Fly   873 KGQDRAIMRTLSGLSSLVTLSTGSGKSLCYQLPAYLYSRKVGAITLVISPLVSLMEDQVTGVPHF 937

Human   731 DIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVID 795
             :.|..|..::|..:...|...::..:  |.:|.|:||.:.|..|.......|.:...:|...||
  Fly   938 -LRAHCLHTNQTAPQRMKIQQMIANGE--IDILLVSPEAVVAGERATGFGAILRQLPPIAFACID 999

Human   796 EAHCVSQWGHDFRQDYKRM-NMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQ--VFSMSF 857
            ||||||||.|:||..|..: .:||:......|:.|||||....:..|:..|.|...:  :.|...
  Fly  1000 EAHCVSQWSHNFRPSYLMICKVLRKNLGVRTVLGLTATATLPTRVSIINHLGISDGERGIISDIP 1064

Human   858 NRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTL-------------- 908
            ...||...|...:.:..|...|....:..|..|.||||..|.||:.:|..:
  Fly  1065 LPDNLVLSVSKDENRDAALLQLLNSERFEPCQSIIIYCTRRDECERIAGFIRTCVQDRREPTQDQ 1129

Human   909 ----QRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKS 969
                :|....|..||||:..|.|..||:.:::.: .:::.|||||||||:|||:|.|||.::|::
  Fly  1130 TKKRKRVNWQAEPYHAGMPASRRRTVQKAFMSNE-LRIVVATIAFGMGINKPDIRAVIHYNMPRN 1193

Human   970 VEGYYQESGRAGRDGEISHCLLFYTYH--DVTRLKRLIMMEKDGNHHTRE 1017
            .|.|.||.|||||||..|||.||....  |.:.|:|.:.......|..|:
  Fly  1194 FESYVQEIGRAGRDGLPSHCHLFLDAKGGDQSELRRHVYSNSIDRHVIRK 1243

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.