DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BLM and rqh1

DIOPT Version :10

Sequence 1:NP_000048.1 Gene:BLM / 641 HGNCID:1058 Length:1417 Species:Homo sapiens
Sequence 2:NP_593092.1 Gene:rqh1 / 2541620 PomBaseID:SPAC2G11.12 Length:1328 Species:Schizosaccharomyces pombe


Alignment Length:1434 Identity:423/1434 - (29%)
Similarity:631/1434 - (44%) Gaps:359/1434 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   192 NFFKAQLYTTNTVKTDLPPPSS--------ESEQIDLTEEQKDDS----EWLSSDVICIDDG--- 241
            :|.|.::.:::.|..|..|..|        :...||||||.:..|    :|  .||    :|   
pombe    34 DFVKVKVSSSDIVVKDSIPHKSKNVFDDFDDGYAIDLTEEHQSSSLNNLKW--KDV----EGPNI 92

Human   242 --PIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAEL-----------------HST---- 283
              ||.::.:  .|.||:      ||..|..|:.....|.|:                 |||    
pombe    93 LKPIKKIAV--PASESE------EDFDDVDEEMLRAAEMEVFQSCQPLAVNTADTTVSHSTSSSN 149

Human   284 -----EKV--PCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDL 341
                 .|:  |.....|:|.:......|..::.|.|::|.      .:...|:......|.|.::
pombe   150 VPRSLNKIHDPSRFIKDNDVENRIHVSSASKVASISNTSK------PNPIVSENPISATSVSIEI 208

Human   342 LSKPEKMS-------MQELNPETSTDCDA---------------RQISLQ-QQLIHVMEHICKLI 383
            ..||:::|       :...|...:.|.:|               .|||:. ....|  :::.:.:
pombe   209 PIKPKELSNNLPFPRLNNNNTNNNNDNNAIEKRDSASPTPSSVSSQISIDFSTWPH--QNLLQYL 271

Human   384 DTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGN 448
            |.:.|:|.::.|...|::::.....:      |.:         |..:.|.|...:        :
pombe   272 DILRDEKSEISDRIIEVMERYPFSSR------FKE---------WIPKRDILSQKI--------S 313

Human   449 SMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAETPRLGK 513
            |:.|:..::..||:.:          |..|.....|..|..|           ||...:.|    
pombe   314 SVLEVLSNNNNSNNNN----------GNNGTVPNAKTFFTPP-----------SSITQQVP---- 353

Human   514 KNESSYFPGNVLTSTAVKDQ------NKH--------------TASINDLERETQPS--YDIDNF 556
                  ||..::..:.||:.      |.|              .|.::.|:...:.|  .:.|.|
pombe   354 ------FPSTIIPESTVKENSTRPYVNSHLVANDKITATPFHSEAVVSPLQSNIRNSDIAEFDEF 412

Human   557 DIDDFD----------DD----------DDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLS 601
            ||||.|          |:          ||.||.:.|...:       |.:|..:...|.:..|.
pombe   413 DIDDADFTFNTTDPINDESGASSDVVVIDDEEDDIENRPLN-------QALKASKAAVSNASLLQ 470

Human   602 SAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLH 666
            |:..| .|:....::.|....:.:..|                ..||:|.:||::.....||.|.
pombe   471 SSSLD-RPLLGEMKDKNHKVLMPSLDD----------------PMLSYPWSKEVLGCLKHKFHLK 518

Human   667 NFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACV----SPGVTVVISPLRSLIVDQVQKL 727
            .||.|||||||..|.|:|.||||||||||||||||||.:    |.|||:|||||.||:.||:..|
pombe   519 GFRKNQLEAINGTLSGKDVFILMPTGGGKSLCYQLPAVIEGGASRGVTLVISPLLSLMQDQLDHL 583

Human   728 TSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARF 792
            ..|:||:..|:|::...|...:...|..|:.::||||||||.:.::..:...|::|||||||||.
pombe   584 RKLNIPSLPLSGEQPADERRQVISFLMAKNVLVKLLYVTPEGLASNGAITRVLKSLYERKLLARI 648

Human   793 VIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSF 857
            |||||||||.||||||.|||::.:||.::..:|.||||||||..|:|||:..|::........||
pombe   649 VIDEAHCVSHWGHDFRPDYKQLGLLRDRYQGIPFMALTATANEIVKKDIINTLRMENCLELKSSF 713

Human   858 NRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRD-GLAALAYHAG 921
            ||.||.|.:.||  |.:..:...:|...|.::|||||||||..|:.:|..|:.| ||.|..||||
pombe   714 NRPNLFYEIKPK--KDLYTELYRFISNGHLHESGIIYCLSRTSCEQVAAKLRNDYGLKAWHYHAG 776

Human   922 LSDSARDEVQQKWINQDGC-QVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGE 985
            |....|..:|.:|  |.|. ::|.||||||||:||.|||||||.|.|||:||||||:|||||||:
pombe   777 LEKVERQRIQNEW--QSGSYKIIVATIAFGMGVDKGDVRFVIHHSFPKSLEGYYQETGRAGRDGK 839

Human   986 ISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGF 1050
            .:||::||:|.|....::|| |..||:..|:|.....|..::.:|||.|:|||.|:||||||| |
pombe   840 PAHCIMFYSYKDHVTFQKLI-MSGDGDAETKERQRQMLRQVIQFCENKTDCRRKQVLAYFGEN-F 902

Human  1051 NPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLV 1115
            :...|:|    .||.||:...|..:|:|:            .|.|.::.:|.:  ||:.|:..|:
pombe   903 DKVHCRK----GCDICCEEATYIKQDMTE------------FSLQAIKLLKSI--SGKATLLQLM 949

Human  1116 DIFLGSKSAKIQSGIF------GKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLG 1174
            |||.|||||||....:      |.|...:|.::||||..|:.:.:..|.:..|......|||:.|
pombe   950 DIFRGSKSAKIVENGWDRLEGAGVGKLLNRGDSERLFHHLVSEGVFVEKVEANRRGFVSAYVVPG 1014

Human  1175 NKAQTVLNGNLK------VDFMETE-----NSSSVKKQKALVA---------------KVSQRE- 1212
            .  ||::|..|.      :|..|:.     :|.|:.:.|.|.|               .:..|| 
pombe  1015 R--QTIINSVLAGKRRIILDVKESSSKPDTSSRSLSRSKTLPALREYQLKSTTASVDCSIGTREV 1077

Human  1213 --------------------------------------EMVKKCLGELTEVCKSLGKVFGVHYFN 1239
                                                  :::.:||.:|..:..:|..:......:
pombe  1078 DEIYDSQMPPVKPSLIHSRNKIDLEELSGQKFMSEYEIDVMTRCLKDLKLLRSNLMAIDDSRVSS 1142

Human  1240 IFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSS 1304
            .|....|..:|:.|..:.:.|.:|.||:.:|....|.:.:.|:||:.:   ..|.:..|..|..|
pombe  1143 YFTDSVLLSMAKKLPRNVKELKEIHGVSNEKAVNLGPKFLQVIQKFID---EKEQNLEGTELDPS 1204

Human  1305 RGPGRSAAEELDEEIPVSSH-----------------YFASKTRNERKRKKMPASQRSKRRKTAS 1352
                   .:.||.:.|:.::                 |..|....|...:  ...||.......:
pombe  1205 -------LQSLDTDYPIDTNALSLDHEQGFSDDSDSVYEPSSPIEEGDEE--VDGQRKDILNFMN 1260

Human  1353 SGSKAKGGSATCRKISSKTKSSSII----GSSSASH-----TSQATSGANSKLGIMAPPKPINRP 1408
            |.|..:.||...||.:|.|:.|...    ||:|.|.     |||..|...|        |..|..
pombe  1261 SQSLTQTGSVPKRKSTSYTRPSKSYRHKRGSTSYSRKRKYSTSQKDSRKTS--------KSANTS 1317

Human  1409 FLKP 1412
            |:.|
pombe  1318 FIHP 1321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BLMNP_000048.1 BLM_N 1..368 CDD:465064 50/242 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..227 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..291 14/68 (21%)
Necessary for interaction with SPIDR. /evidence=ECO:0000269|PubMed:23509288 301..600 63/363 (17%)
Necessary for dimerization and homooligomerization. /evidence=ECO:0000269|PubMed:28228481 362..414 10/67 (15%)
BDHCT 372..412 CDD:462356 6/39 (15%)
BDHCT_assoc 425..647 CDD:465065 46/263 (17%)
recQ_fam 657..1143 CDD:129701 239/497 (48%)
DEAH box 795..798 2/2 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:25901030 870..873 0/2 (0%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 897..899 1/1 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1000..1003 0/2 (0%)
DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:24257077 1094..1139 18/50 (36%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1110..1112 1/1 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1121..1125 3/3 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1160..1166 1/5 (20%)
HRDC 1213..1292 CDD:128635 17/78 (22%)
Necessary for ssDNA and DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:20639533 1227..1244 2/16 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1417 34/150 (23%)
Nuclear localization signal. /evidence=ECO:0000255 1334..1349 2/14 (14%)
rqh1NP_593092.1 RecQ 511..1007 CDD:440280 246/519 (47%)
HRDC 1115..1195 CDD:128635 18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

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