DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BLM and him-6

DIOPT Version :10

Sequence 1:NP_000048.1 Gene:BLM / 641 HGNCID:1058 Length:1417 Species:Homo sapiens
Sequence 2:NP_502390.2 Gene:him-6 / 178201 WormBaseID:WBGene00001865 Length:988 Species:Caenorhabditis elegans


Alignment Length:1004 Identity:343/1004 - (34%)
Similarity:493/1004 - (49%) Gaps:167/1004 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   488 ERPLFNTHLQKSFVSSNWAETPRLGKKNE------SSYFPG----NVLTSTAVKDQNKHT-ASIN 541
            |.|:....:|:|........:|...:.:|      |||.||    |.......:.|.:.. ..|.
 Worm    61 EPPVEVNRIQESTSFDEPVSSPPRYRPSENPGPSSSSYEPGHYSFNEYQQFPSRPQKRLVDPPIV 125

Human   542 DLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTD 606
            ||:.| .|..|:|: ..|:|......|:::      ....|..:..:||..        |....:
 Worm   126 DLDEE-PPIVDLDD-SFDNFHVGSTSEEVV------SGDIAPEEEEEEGHD--------SFDDFE 174

Human   607 CLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQS---------------LSFPHTKEMM 656
            .:|....::|.  ..|:|....:.|.| ..|:..|.||:.               |.....||:.
 Worm   175 SVPAQPPSKNT--LASLQKSDSEIALN-QQRHDMHGRFRGFLQDDSEEFSDEVGLLGADMNKELY 236

Human   657 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIV 721
            .....|||.:.||..|.:.|.:.|:|.|.|:|||||.||||||||||.:.||||||:|||||||.
 Worm   237 DTLKSKFGFNQFRHRQKQCILSTLMGHDTFVLMPTGAGKSLCYQLPAVILPGVTVVVSPLRSLIE 301

Human   722 DQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYER 786
            ||..|:..|.|....||.|........||.:|...:|.|||||||||||.||.||.|...:|:.|
 Worm   302 DQKMKMKELGIGCEALTADLGAPAQEKIYAELGSGNPSIKLLYVTPEKISASGRLNSVFFDLHRR 366

Human   787 KLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKF--PSVPVMALTATANPRVQKDILTQLKILR 849
            .|||||||||||||||||||||.||.:::.||:|:  |.||::||||||.|::..|....||:..
 Worm   367 GLLARFVIDEAHCVSQWGHDFRPDYTKLSSLREKYANPPVPIIALTATATPKIVTDARDHLKMQN 431

Human   850 PQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLA 914
            .::|..||.|.||||.::||..:.: .:.:|.:::.:|..|||:|||||:||:|:...|.:.||:
 Worm   432 SKLFISSFVRDNLKYDLIPKAARSL-INVVEKMKQLYPGKSGIVYCLSRKECETVQMMLTKAGLS 495

Human   915 ALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGR 979
            |..|||||:|:.|..||:.|| .:...||||||||||||||||||||||.|||||:||||||:||
 Worm   496 AEVYHAGLNDNLRVSVQRSWI-ANKFDVICATIAFGMGIDKPDVRFVIHYSLPKSIEGYYQETGR 559

Human   980 AGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHT--RETHFNNLYSMVHYCENITECRRIQLL 1042
            |||||..|:||:.|:|||..||:|:|   ::||..|  |..|.||:..:|.||||::.|||..|:
 Worm   560 AGRDGMPSYCLMLYSYHDSIRLRRMI---EEGNTTTGVRSMHLNNVLQVVAYCENVSVCRRKMLV 621

Human  1043 AYFGENGFNPDFCK--KHPDVSCDNCCKTKD----YKTRDVTDDVKSIVRFVQEHSSSQGMRNIK 1101
            .:||| .::...|:  |.|   ||.|.:.:.    .:..||:.|..||::.:.....:       
 Worm   622 EHFGE-VYDEQSCRNSKTP---CDICERQRKNAEAIRLFDVSTDALSILKCLPRMQKA------- 675

Human  1102 HVGPSGRFTMNMLVDIFLGSKSAKIQS----------GIFGKGSAYSRHNAERLFKKLILDKILD 1156
                    |:..:.:::.|:...|.|.          ..:.||...|..:|.|..:||:::..:.
 Worm   676 --------TLKYISELYRGALIKKSQEQAMRLGHTKLPFYSKGQGMSEQDALRFVRKLVIEGYIH 732

Human  1157 EDLYINANDQA--IAYVMLGNKAQTVLNG--NLKV--------------DFMETENSSSVKKQKA 1203
            |.||...|..|  .||..|....:.:.||  ..||              ..:|..|.:.|.:.:|
 Worm   733 ERLYSVPNQAAAVFAYAELTEAGRDLANGKKTAKVYLHIVTCERKRKNAGLIELSNMNIVSEAQA 797

Human  1204 LVAKVSQREEMVK------KCLGELTEVCKSLGKVFGVH-YFNIFNTVTLKKLAESLSSDPEVLL 1261
            |     :...|||      :||.:||.:..::.:..|:. .::|.:...::::|..|......||
 Worm   798 L-----KERHMVKHGDVFTRCLQDLTHLITAVAESSGLSGPYSIVSREGIEQIAALLPRTNSDLL 857

Human  1262 QIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIPVSSHYF 1326
            :||.:|:.|:.|||..::.:|..|  |                     ...:|.:||        
 Worm   858 RIDSMTQIKVTKYGRLIMELLATY--W---------------------KQVDEREEE-------- 891

Human  1327 ASKTRNERKRKKMP-------ASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSSSASH 1384
              :.||:..:.|..       |:.:|.....:....|..||...||   .:.|..:..|.||...
 Worm   892 --EMRNQLDKLKSGEIVMGGFATLQSDPGFPSVPYMKPLGGGGGCR---GRGKKRAFSGFSSGRA 951

Human  1385 TSQATSGANSKLGIMAPPKPINRPFLKPS 1413
            |.:..:.|.|..|     |...|...||:
 Worm   952 TKKPRATAPSARG-----KTSGRGGAKPA 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BLMNP_000048.1 BLM_N 1..368 CDD:465064
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..227
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..291
Necessary for interaction with SPIDR. /evidence=ECO:0000269|PubMed:23509288 301..600 26/122 (21%)
Necessary for dimerization and homooligomerization. /evidence=ECO:0000269|PubMed:28228481 362..414
BDHCT 372..412 CDD:462356
BDHCT_assoc 425..647 CDD:465065 37/184 (20%)
recQ_fam 657..1143 CDD:129701 234/505 (46%)
DEAH box 795..798 2/2 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:25901030 870..873 0/2 (0%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 897..899 1/1 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1000..1003 2/2 (100%)
DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:24257077 1094..1139 6/54 (11%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1110..1112 1/1 (100%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1121..1125 0/3 (0%)
3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M 1160..1166 2/5 (40%)
HRDC 1213..1292 CDD:128635 23/85 (27%)
Necessary for ssDNA and DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:20639533 1227..1244 2/17 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1417 25/132 (19%)
Nuclear localization signal. /evidence=ECO:0000255 1334..1349 3/21 (14%)
him-6NP_502390.2 RecQ 231..728 CDD:440280 240/520 (46%)
HRDC 807..888 CDD:128635 20/103 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.