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Protein Alignment BLM and blm
DIOPT Version :10
| Alignment Length: | 51 |
Identity: | 13/51 - (25%) |
| Similarity: | 22/51 - (43%) |
Gaps: | 2/51 - (3%) |
- Green bases have known domain annotations that are detailed below.
|
Human 171 VKEIEAIESDSFVQQTFRSSKDVKKAVEPSEVQHVTAASGPASAAAEPPST 221
:||:....|:.|:..|.|...|..||.:..:..|::... .....:||.|
Frog 1 MKEVNKALSNQFISLTKRDFVDRSKAQKIKKSSHLSLEW--KKLLPQPPDT 49
|
Known Domains:
Indicated by green bases in alignment.
| Gene | Sequence | Domain | Region |
External ID | Identity |
| BLM | NP_000048.1 |
BLM_N |
1..368 |
CDD:465064 |
13/51 (25%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite |
1..21 |
|
|
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite |
203..227 |
|
4/19 (21%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite |
250..291 |
|
|
| Necessary for interaction with SPIDR. /evidence=ECO:0000269|PubMed:23509288 |
301..600 |
|
|
| Necessary for dimerization and homooligomerization. /evidence=ECO:0000269|PubMed:28228481 |
362..414 |
|
|
| BDHCT |
372..412 |
CDD:462356 |
|
| BDHCT_assoc |
425..647 |
CDD:465065 |
|
| recQ_fam |
657..1143 |
CDD:129701 |
|
| DEAH box |
795..798 |
|
|
| 3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:25901030 |
870..873 |
|
|
| 3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
897..899 |
|
|
| 3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
1000..1003 |
|
|
| DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:24257077 |
1094..1139 |
|
|
| 3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
1110..1112 |
|
|
| 3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
1121..1125 |
|
|
| 3' overhang DNA-binding. /evidence=ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
1160..1166 |
|
|
| HRDC |
1213..1292 |
CDD:128635 |
|
| Necessary for ssDNA and DNA Holliday junction binding. /evidence=ECO:0000269|PubMed:20639533 |
1227..1244 |
|
|
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite |
1289..1417 |
|
|
| Nuclear localization signal. /evidence=ECO:0000255 |
1334..1349 |
|
|
| blm | XP_012813863.2 |
BLM_N |
1..336 |
CDD:465064 |
13/51 (25%) |
| BDHCT |
341..380 |
CDD:462356 |
|
| recQ_fam |
611..1094 |
CDD:129701 |
|
| HRDC |
1165..1243 |
CDD:128635 |
|
|
Blue background indicates that the domain is not in
the aligned region.
|
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