DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMOC1 and magu

DIOPT Version :10

Sequence 1:NP_001412173.1 Gene:SMOC1 / 64093 HGNCID:20318 Length:446 Species:Homo sapiens
Sequence 2:NP_610548.2 Gene:magu / 36048 FlyBaseID:FBgn0262169 Length:613 Species:Drosophila melanogaster


Alignment Length:573 Identity:129/573 - (22%)
Similarity:196/573 - (34%) Gaps:229/573 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    54 PICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQE---AVFV 115
            |:|.:||::|.:.|...||:|....:.:.:.|.|     :.|    .:|::.|::.||   ..||
  Fly    44 PVCGTDGQTYPTRCHLLRAQCGGHQVSLKYSGSC-----NAC----LEAVKFARRQQERDPGYFV 99

Human   116 PECGEDGSFTQVQCHTYTGYCWCVTPDGKPIS--------------------------------- 147
            |.|.:||:|..:||:...| |||....|:||:                                 
  Fly   100 PRCRKDGNFAAMQCYGNNG-CWCSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNP 163

Human   148 ------GSSVQNKTPVCSGSVTDKPLSQGNSGRKVSFR-----FFLTLNSDDG-------SKPTP 194
                  |||....|...:.|.:|:  ||.|:.....||     ||...:..|.       ||   
  Fly   164 DTSASKGSSEAGSTAHRTCSKSDR--SQFNTNLMRMFRNEAQSFFRQPSLSDSHILEWQFSK--- 223

Human   195 TMET--QPVFDGDEITAPTLWIKHL-------------------VIKDSKLN------------- 225
             ::|  ..:.|..||..    :|.:                   |.||:.||             
  Fly   224 -LDTNGNKLLDRQEIRE----LKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFH 283

Human   226 --------------------------NTNIR---------------------------------- 230
                                      |||:.                                  
  Fly   284 NRSAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYE 348

Human   231 -------------------------------NS---------EKVYSCDQERQSALEEAQQNPRE 255
                                           ||         |...:|..::...|||.....:.
  Fly   349 DSATGYGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTLEEQGHGGKS 413

Human   256 GIVIPECAPGGLYKPVQCHQ--STGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPF 318
            .:.:|:|.|.|.|:.:||:.  ||.|||||..|||:.:||||.:...|.|           |:..
  Fly   414 VLFVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQC-----------DESV 467

Human   319 KDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLD 383
            ..|.:.||.|.:|.:|:..|...|.|.::    .::.||    |......|.:||:....|..||
  Fly   468 AVRPMKGCTEPRKTQFLKELKAYLNTSLL----PSSTTG----SNSSMWKTDDERIATLSFVYLD 524

Human   384 SNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCL 436
            .|.:...::||.|.|:..|...:..::|.::...|||:|.||.|||.|...||
  Fly   525 KNKNKSWDRREWKNFRDLVTSASHLRRCGKKMPRYCDVNGDKKISLAEWLNCL 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMOC1NP_001412173.1 KAZAL_FS 47..87 CDD:238052 10/32 (31%)
Thyroglobulin_1 95..158 CDD:459665 25/104 (24%)
Thyroglob_assoc 159..230 CDD:435450 25/142 (18%)
Thyroglobulin_1 238..303 CDD:459665 26/66 (39%)
EFh_SPARC_SMOC1 326..440 CDD:320019 35/111 (32%)
EF-hand motif 371..403 CDD:320019 10/31 (32%)
EF-hand motif 408..440 CDD:320019 13/29 (45%)
maguNP_610548.2 KAZAL_FS 38..77 CDD:238052 10/32 (31%)
TY 88..139 CDD:238114 18/51 (35%)
EFh_SPARC_SMOC 182..280 CDD:320013 22/107 (21%)
EF-hand motif 213..245 CDD:320013 8/39 (21%)
EF-hand motif 250..280 CDD:320013 5/29 (17%)
TY 396..463 CDD:238114 26/66 (39%)
EFh_SPARC_SMOC 475..577 CDD:320013 33/109 (30%)
EF-hand motif 512..544 CDD:320013 10/31 (32%)
EF-hand motif 549..577 CDD:320013 11/27 (41%)

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