Protein Alignment CLSTN2 and Cals

DIOPT Version :10

• Sequence 1: NP_071414.2
• Gene: CLSTN2 / 64084
• HGNCID: 17448
• Length: 955
• Species: Homo sapiens
• Sequence 2: NP_001259086.1
• Gene: Cals / 43824
• FlyBaseID: FBgn0039928
• Length: 979
• Species: Drosophila melanogaster
• Alignment Length: 1013
• Identity: 311/1013 - (30%)
• Similarity: 499/1013 - (49%)
• Gaps: 181/1013 - (17%)

Human    44 IETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKI-----HGQELPFEAVVLNKTSGE 103
            :|.||||:|.| |:|::...||:.::::       :||.|.|     |  |:||:..::|..
  Fly    42 LEKSYHGLIRE-NETLVEITPLIKVNEE-------KICNFHILKKPYH--EIPFKIELVNNL--- 93

Human   104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAV 168
            |.|:|:..::||.:|.|.|.|.|..|...|       |:.|.|||.|.||||:||||.||:|...
  Fly    94 GILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIE 151

Human   169 VTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILV 233
            |.||::|:.||:|||.|:||:|.:..:|.|||:..|.||:||..|:|:|||.||:...|.:.:.|
  Fly   152 VDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSV 216

Human   234 TAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGS-GSMPLFPSIHLETCDGAVSS--- 294
            .||||..|.:| ..:|.:.|:.||:..:....:||:|..|| .|:.|||:..|:.||.:..:
  Fly   217 VAYDCAMKESA-PIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEED 280

Human   295 LQIVTE--LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSS-EMIF 356
            |:|.:.  |:|.:|..||||:..:       |.:...:.||||.   ...||..|..|.. |.||
  Fly   281 LRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLPH---GAEWTKELSYDEGLEPIF 335

Human   357 KFDGRQGAKVPDGIVPK-NLTDQ-FTITMWMKHGPSPGVRAE-KETILCNSDKTEMNRHHYALYV 418
            .|||..|..||..::.. :.:.| |:|....:|.....:... ||.|:|::|..:|||||.||:|
  Fly   336 HFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFV 400

Human   419 HNCRLVFLLRKDFDQAD--TFRPAEFHWKLDQICDKEWHYYVINVE-FPVVTLYMDGATYEPYL- 479
            .||||:|||||:|::.|  .|.|||:.||:.::||.|||:||:||| ...|.|::||..:|..:
  Fly   401 RNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIE 465

Human   480 -------VTNDWPIHPSH-IAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVIS 536
                   |.:|||:|.:| :...|.:|||:|..|   .:....|:|.::.:.:....:.:.:.|.
  Fly   466 NRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLE---NRLKHGFNGDISEVKVSLNSVLTAEDIK 527

Human   537 CLQACKE------GLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPT 595
            |...|.|      .|..|:.:|.....:...|...:.:.:...:..:|.:.::||.|||::|.||
  Fly   528 CGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPT 592

Human   596 AGVRRLKVSSKVQCFGEDVCISIPEVDAYVMVLQAI------------------------EPRIT 636
            .|.|.::|.:.:.|..|. .:.:|.::.|:||.:.|                        .|:|.
  Fly   593 VGRRNIEVLTTLNCKNES-SLRLPPIETYIMVNEPIAPLGIDIDVVSASLETSDLTPPSYSPKIA 656

Human   637 LRGTDHFWRPAAQFESARGVTLFPDIKI-VSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDIL 700
            :.||            :..:..:.:||: |....||    .:.:....:..|||..| :|.|.::
  Fly   657 ISGT------------SNKLVSYQEIKLGVHILEKT----CIDSVSKNNGKLEEKNH-IDSCSVV 704

Human   701 VIGGDLDPRQECLELNHSELHQRHLD-ATN-STAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLE 763
            |. ..|:|..|.::::..|.....:| .|| :..|..:.|..::|.|..||..:.|.|.:||...
  Fly   705 VF-PSLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYL 768

Human   764 ARRFRIKCSELNGRYTSNEFNLEVSILHEDQV--------------------SDKE---HVNHLI 805
            .|.|::.|::.:.:|.|.|:.|.:::||..|.                    :|.|   |.|...
  Fly   769 NRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGS 833

Human   806 V------QPP----------FLQSVHHPESR-SSIQHSSVVPSIATVVIIISVCMLVFVVAMGVY 853
            |      ||.          ...:|..|:|. .|..|.:....:..::|::||.:.|.:..:.:.
  Fly   834 VNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLAVLLCGVSIA 898

Human   854 RVRIAHQHFIQETEAAKESEMD---WDDSALTITVNPMEKHEGPGHGEDETEGEEEEEAEEEMSS 915
            |:: .:|.:|:..:...:...|   |||||||||:|||                   :|:....:
  Fly   899 RLK-NNQKYIEHHQPCPKISDDGLIWDDSALTITINPM-------------------QADVTSDA 943

Human   916 SSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTL 953
            ||.|::||.|:||..:..|....|     |||||:|.:
  Fly   944 SSESENSESEDEEVALKDGFTHIN-----QLEWDNSNI 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLSTN2	NP_071414.2	Cadherin_repeat	47..155	CDD:206637	39/112 (35%)
		Cadherin_repeat	165..256	CDD:206637	40/90 (44%)
		CLSTN_C	546..892	CDD:466150	97/415 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	887..955		19/67 (28%)
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	39/112 (35%)
		CA_like	148..235	CDD:481204	39/87 (45%)
		Laminin_G_3	<435..527	CDD:463865	28/94 (30%)
		CLSTN_C	573..936	CDD:466150	94/401 (23%)