DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SEMA3F and Sema1a

DIOPT Version :9

Sequence 1:	NP_004177.3	Gene:	SEMA3F / 6405	HGNCID:	10728	Length:	785	Species:	Homo sapiens
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	220/849 - (25%)
Similarity:	362/849 - (42%)	Gaps:	199/849 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     7 LLWASLLTG---AWPSFPTQDHLPATPRVRLSFKE-LKATGTA----HFFNFLLNTTDYRILLKD 63
            ||...|:.|   ||     |:::.....|.|..:: ||..|..    ||            .|..
  Fly    54 LLLTVLVIGNQSAW-----QENIRPKLYVELGPEDVLKFVGNESVVDHF------------KLVT 101

Human    64 EDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRT 128
            :|.:.:.:|:::.|.:|.:||:..:..:: |.:.....:.|::.|||... |.|::|::...:..
  Fly   102 KDGNSLLIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPG 164

Human   129 HLYVCGTGAYNPMC-TYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPE 192
            .|:||||.::.||| ||:                                    ..|..:.||..
  Fly   165 RLFVCGTNSFRPMCNTYI------------------------------------ISDSNYTLEAT 193

Human   193 RLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPS 257
            :  :|:..|||||:.::.|.|.:.|||:|...||.|:|..|:|     ..::|:||:|..||.|:
  Fly   194 K--NGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPN 251

Human   258 FIHAELIPDSAERNDDKLYFFFRERSAEAPQ-SPAVYARIGRICLNDDGGHCCLVNKWSTFLKAR 321
            |:       |:....|.:||||||.:.|... ..|:|:|:.|:|..|.||.....|:|::|||:|
  Fly   252 FV-------SSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSR 309

Human   322 LVCSVPGEDGIETHFDELQ---DVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF 383
            |.||:||:  ...:|:|:|   ::...|...:.:.:||.||.:..:...|||||.:::.||...|
  Fly   310 LNCSIPGD--YPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTF 372

Human   384 NGPFAHKEGPNYQWMPF-SGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYP 447
            .|.|..:.|.|..|:|. :.|:|.||||:|        ...::..||..:||:::|.||.:.|..
  Fly   373 EGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVPA 429

Human   448 LQRRPLVVRTGAPYRLTTIAVD-QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDD--QELEELML 508
            ...:|::|||...||.|.|||| |:....|: |:|:|:|||.|.:.|.:.....|  .::..:::
  Fly   430 FFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVI 494

Human   509 EEVEVFKDPAPVKTMTISSKRQ------------QLYVASAVGVTHLSLHRCQAYG-AACADCCL 560
            ||::|.....|::.:.|....|            :|.:.:...|..:.||||.... .:|::|..
  Fly   495 EEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVA 559

Human   561 ARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLE 625
            .:|||||||       ..:.|.||      ||.|    |....|.....|.:.|:....|...
  Fly   560 LQDPYCAWD-------KIAGKCRS------HGAP----RWLEENYFYQNVATGQHAACPSGKI-- 605

Human   626 CQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLY----------SCTA 680
               .|..|..                .|.:..|.:..||....|..|:.:.          ..:|
  Fly   606 ---NSKDANA----------------GEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISA 651

Human   681 TENNFKHVVTRVQLHVLGRDAVHAALFPPL-----------------SMSAPPPP---------- 718
            ...|.::.|..:.:.||.     .::|..|                 ..:.|.|.
  Fly   652 DIINAQYTVETLVMAVLA-----GSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQ 711

Human   719 --GAGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHH 781
              .:.|.:...|:..:||.|.|.   ..|.:......||.|.:.    .||:...:|.|.::.|.
  Fly   712 NVNSFPSSCRIQQEPKLLPQVEE---VTYAEPVLLPQPPPPNKM----HSPKNTLRKPPMHQMHQ 769

Human   782 PPDT 785
            .|::
  Fly   770 GPNS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEMA3F	NP_004177.3	Sema_3F	48..548	CDD:200515	151/521 (29%)
		PSI	547..584	CDD:214655	12/37 (32%)
		Ig_Semaphorin_classIII	609..697	CDD:143279	14/97 (14%)
		IG_like	612..696	CDD:214653	13/93 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..785		9/32 (28%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	153/528 (29%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	15/46 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910