DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khdrbs3 and how

DIOPT Version :9

Sequence 1:	NP_071585.2	Gene:	Khdrbs3 / 64015	RGDID:	620921	Length:	346	Species:	Rattus norvegicus
Sequence 2:	NP_001262822.1	Gene:	how / 42596	FlyBaseID:	FBgn0264491	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	106/354 - (29%)
Similarity:	162/354 - (45%)	Gaps:	45/354 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat     5 YLPELMAEKDSLD--PS-FTHALRLVNREIEK-----FQKGEAKDEEKYIDVVINKNMKLGQKVL 61
            ||.:|:.::..|.  |: |||..||::.||.:     ||....|.|...:.......:.:.:||.
  Fly    78 YLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVVTMNEKVY 142

  Rat    62 IPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDD 126
            :||::.|.|||||::|||||.:.|:|::||..|:.:.||||||||.||:..|  |:..:.||:||
  Fly   143 VPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANR--GKPNWEHLSDD 205

  Rat   127 LHVLIEVFAPPAEAYARMGHALEEIKKFLIP--DYNDEIRQAQLQELTYLNGGSENADVPVVRGK 189
            |||||.|......|..::..|:.|::|.|:|  :..||:::.||.||..:||...:.....|...
  Fly   206 LHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVAAF 270

  Rat   190 STLRTRGVTTPAITRGRGGVTARPVAVGVPR---GTPTPRGVLSTRGPVSRGRG---LLTPRARG 248
            |.:.:.....||:....   ..|.||....|   .|..|......|.|.:...|   :|.||..
  Fly   271 SCVGSASYLYPAVCDEE---WRRLVAASDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMT- 331

  Rat   249 VPPT-----GYRPPPPPPTQETYGEYDYDDGYSTAYDDQSYDSYDNSYSTPAQSGADYYDYGHGL 308
            ||.|     ..:..|.....:|        |:...:....|.:|......|..:  :|.|:...:
  Fly   332 VPTTAASILSAQAAPTAAFDQT--------GHGMIFAPYDYANYAALAGNPLLT--EYADHSGAI 386

  Rat   309 GEEAYDSYGQEDWTNSRHKAPSARTAKGV 337
            .::      :...||..|  |..|...||
  Fly   387 KQQ------RRLATNREH--PYQRATVGV 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khdrbs3	NP_071585.2	Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:O75525	1..160		64/164 (39%)
		Qua1	4..53	CDD:406639	16/55 (29%)
		KH-I_KHDRBS3	48..160	CDD:411898	48/113 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..268		17/66 (26%)
		Sam68-YY	266..320	CDD:406871	6/53 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..346		7/18 (39%)
how	NP_001262822.1	STAR_dimer	75..123	CDD:293152	15/44 (34%)
how	NP_001262822.1	SF1_like-KH	139..260	CDD:239088	56/122 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810