DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SELE and lectin-22C

DIOPT Version :9

Sequence 1:	NP_000441.2	Gene:	SELE / 6401	HGNCID:	10718	Length:	610	Species:	Homo sapiens
Sequence 2:	NP_001137766.1	Gene:	lectin-22C / 7354375	FlyBaseID:	FBgn0259230	Length:	263	Species:	Drosophila melanogaster

Alignment Length:	146	Identity:	34/146 - (23%)
Similarity:	57/146 - (39%)	Gaps:	21/146 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     7 LSALTLVLL-----IKESG------AWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLN 60
            ||||...:|     ||..|      .:.|........:..||..|:....||..|:::.::..:.
  Fly   120 LSALEKTVLEVKTKIKYLGFEQIGSKYYYIEKVSEKNWSTASKTCRNMGGHLADIKDEADLAAIK 184

Human    61 SILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDE-DCVEIYIKREKDVGM 124
            :.|. ..::||:||..:::...::............||.|.|:  |.|. :||.:|      .|.
  Fly   185 ANLK-EDTHYWLGINDLDHEGKFLSMPTGKQTTFLKWASGRPS--QLDTLNCVFLY------NGE 240

Human   125 WNDERCSKKKLALCYT 140
            ..|..|......:|.|
  Fly   241 MYDYPCHYTFRFICQT 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SELE	NP_000441.2	CLECT_selectins_like	22..140	CDD:153062	25/118 (21%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:26117840, ECO:0007744\|PDB:4C16, ECO:0007744\|PDB:4CSY	101..109		2/7 (29%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:26117840, ECO:0007744\|PDB:4C16, ECO:0007744\|PDB:4CSY	113..118		1/4 (25%)
		Carbohydrate binding. /evidence=ECO:0000269\|PubMed:26117840, ECO:0007744\|PDB:4C16, ECO:0007744\|PDB:4CSY	126..128		0/1 (0%)
		EGF_CA	<148..175	CDD:238011
		CCP	199..425	CDD:332582
		CCP	333..547	CDD:332582
lectin-22C	NP_001137766.1	CLECT	146..255	CDD:153057	24/117 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910