Protein Alignment MYO1G and MYO3

DIOPT Version :9

• Sequence 1: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1013
• Identity: 354/1013 - (34%)
• Similarity: 531/1013 - (52%)
• Gaps: 144/1013 - (14%)

Human     8 EYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELY 72
            |.|..|..||.:::.|....||:.||:.|.||||||.||:||||:::|.:|....:..|:|:...
Yeast    35 EVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRL 99

Human    73 ERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDV 137
            |.|||::|:|.:.|..:|..:.:.|::||||||||||||:|.|||||||.:| |....:.::||:
Yeast   100 EVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASN-SHSESIGKIKDM 163

Human   138 LLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFH 202
            :|.:..:||:||.|:|.||:||||.|||::|.|:.:.:|..|:|.:|||||.||:.|...|||||
Yeast   164 VLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFH 228

Human   203 AFYQLLRGSED--KQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFS 265
            .|||..:|:.|  ||:..:.:   |..|.:|   |....|....:| |.:.::...||||.||..
Yeast   229 IFYQFTKGASDTYKQMFGVQM---PEQYIYT---AAAGCTTADTID-DVKDYEGTLEAMRTIGLV 286

Human   266 PEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLART 330
            .||.:.:.|:|||||.:|||.|:|.|||..|     |.:.::.|.||.|......|:::.|:.|.
Yeast   287 QEEQDQIFRMLAAILWIGNISFIENEEGNAQ-----VGDTSVTDFVAYLLQVDASLLVKCLVERI 346

Human   331 V-ASGGRELIEKGH---TAAEASYARDACAKAVYQRLFEWVVNRINSVME--PRGRDPRRDGKDT 389
            : .|.|.:.....|   ...:|:..|||.|||:|..||:|:|:|:|..::  |        |.|.
Yeast   347 MQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFP--------GADK 403

Human   390 VIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIV 454
            .||:|||||||:|..|||||.||||.||||||:||||.||.|||.||||.|.|..::||:|..:.
Yeast   404 SIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVC 468

Human   455 DLVERPH-RGILAVLDEACSSA---GTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDF 515
            ||:|..: .||||.::::.::|   ....|:.|.|.|::.:.:. ::..|           ...|
Yeast   469 DLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRLNLFNSNP-YFELR-----------ANKF 521

Human   516 RIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTK-RPLTAGTL 579
            .||||||||||.:.|..|||:|.|.:|...|:..:|:..|..::||   |:.:.:| ||.|||..
Yeast   522 VIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPD---DVDKDSKRRPPTAGDK 583

Human   580 FKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPY 644
            ...|...|||.|:..||.|:|.||||:.|.....|::...|||.||||.||||:||||||.||.:
Yeast   584 IIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTF 648

Human   645 SRFLLRYKM---TC----EYTWPNHLLGSDKAAV-SALLEQHGLQGDVAFGHSKLFIRSPRTLVT 701
            .:|:.|:.:   .|    :|||....|.:.|..: .|::.:...|    .|.:.:||::|.:|..
Yeast   649 EKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQ----LGVTSVFIKTPESLFA 709

Human   702 LEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPP 766
            ||..|.:....:...:|:|||    |:..||:.|...|.|..|..|......:|:.
Yeast   710 LEDMRDKYWYNMAARIQRAWR----RFLQRRIDAAIKIQRTIREKKGGNKYVKLRD--------- 761

Human   767 LYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGC 831
             ||..|                  |..:...|.:                    :|.|.
Yeast   762 -YGTKL------------------LAGKKERRSM--------------------SLLGY------ 781

Human   832 RRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGF---GAVLFSSHVRKVNRFHKIRNRALLLTD 893
             ||:..||| |..::.|..| :.:|...::||..|   |..|.|...|...|..|:    .:||.
Yeast   782 -RAFMGDYL-SCNESKTKGS-YIRRQVGIKDKVVFSIKGECLHSKFGRSAQRLKKV----FILTK 839

Human   894 QHLYKLDPDRQYRVMR-----AVPLEAVTGLSVTSGGDQ---LVVLHARGQDDLVVCLHRSR--- 947
            :..|.:...|:...|:     .:.:..:..:|:|:..|.   ::::::...|.|:....::.
Yeast   840 KTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMT 904

Human   948 --PPLDNRVGELVG-VLAAHCQ-GEGRTLEVRVSDCIP 981
              ..|:.::...|| .:..|.| .:..|:..::||..|
Yeast   905 RLKKLNEKIMIKVGPTIEYHKQPNKLHTVRSKISDSAP 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	296/718 (41%)
		MYSc_Myo1	23..694	CDD:276829	286/691 (41%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		11/21 (52%)
		Myosin_TH1	815..980	CDD:283635	38/182 (21%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	354/1013 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810