Protein Alignment MYO1G and hum-5

DIOPT Version :9

• Sequence 1: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Sequence 2: NP_497809.1
• Gene: hum-5 / 175521
• WormBaseID: WBGene00002038
• Length: 1017
• Species: Caenorhabditis elegans
• Alignment Length: 1005
• Identity: 475/1005 - (47%)
• Similarity: 661/1005 - (65%)
• Gaps: 52/1005 - (5%)

Human     3 DEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQ 67
            |..|  ||..|.|||..:.::..::||||||:|||||||||||||:||||::|.:|....:.:|:
 Worm     7 DPNG--YGVEDLVLLSTIDLKSVVQNLQLRFQKGRIYTYIGEVLVAVNPYRQLGIYEKSTVDQYK 69

Human    68 GRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVE 132
            |||:|||.||::|:|:|||::||...||:||||||||||||||.||.||:|:||:||..|:.|:|
 Worm    70 GREIYERAPHVFAIADAAYRSMKRFGRDSCIVISGESGAGKTETSKIIMKYLAAITNVRQQGEIE 134

Human   133 RVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVG 197
            |||:|||:|.|:|||||.|:|.||.|||||||||.||||:.|||:||:|.:||||||||::|..|
 Worm   135 RVKNVLLRSNCILEAFGCAKTTRNDNSSRFGKYMHINFDYDGDPVGGNISNYLLEKSRVVRQQEG 199

Human   198 ERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQG-----AGLNMTVHSALDSDEQSHQAVTE 257
            |||||.||||:.|.:|..|.:..|.::...|.|.:||     |.:|         |.:....|..
 Worm   200 ERNFHVFYQLVNGGDDGLLRQFGLTKDAKQYYFLNQGQSHKVASIN---------DSRDFAEVQT 255

Human   258 AMRVI-GFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAE-LTATPRD 320
            |:|.| .|..::|||:..::|.::||||:.|::.|.   ....:.:||:|.:.:.|. |..||.:
 Worm   256 ALRSIHTFDKQDVESMWSVIAGLIHLGNVRFIDGEN---SSGAVHIAEKAALQNAARCLNVTPDE 317

Human   321 LVLRSLLARTVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRD 385
            |. :||.::.||:.| ::::|.|....|.|.|||.|||:|:|||.|:|:::|..:..  ::..|.
 Worm   318 LA-KSLSSQVVAAHG-DIVKKQHDVNAAYYTRDALAKALYERLFSWMVSKVNEAISV--QNSSRY 378

Human   386 GKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNN 450
            .|..|||||||||||:|..|||||.||||||||||||||:|:|||||||||||||.|..:|||||
 Worm   379 SKSHVIGVLDIYGFEIFGTNSFEQLCINYCNEKLQQLFIELVLKQEQEEYEREGIKWVKIEYFNN 443

Human   451 ATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDF 515
            ..|.||||.|..|||::|||||:|.|.:||::||..||...:.|.|||||.|..:||:|.| .:|
 Worm   444 KVICDLVEIPRTGILSILDEACASIGNVTDKVFLGELDKKLKSHKHYTSRNLKQSDKSMGF-EEF 507

Human   516 RIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLF 580
            :|.||||||||||.||:|||:|.||||.|||||:|.:..:::::|||.:.:.||.:||.|||.||
 Worm   508 KITHYAGDVTYSVMGFMDKNKDTLFQDLKRLLYHSKNRLVKSLFPDGSKSMAEVNRRPPTAGFLF 572

Human   581 KNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYS 645
            ||||..||:.||.|||.|:|||||||:|.:...|.....|||.||||||||||||||||.|.||.
 Worm   573 KNSMSELVKQLAQKEPHYIRCIKPNEEKNSNVFDLERVEHQVRYLGLLENVRVRRAGFAHRMPYD 637

Human   646 RFLLRYKMTCEYTWPNHLLGSD-KAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARL 709
            ||:.|||:.|..||||...|.. |.:...:||..||..|...|.:|:|||||:|:..||:.|...
 Worm   638 RFVNRYKLICASTWPNPRRGQQLKDSCMQILESAGLAQDCVQGRTKIFIRSPQTVFRLEELRTEQ 702

Human   710 IPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVW 774
            :|.::..|||..||...|.|.||:.|:..|:..:||:|:::::.:|...|:..|:....|:.:.|
 Worm   703 LPNVITFLQKMVRGVQQRERYRRMLAVRKIIGAYRRYKLKSYIWQLINAFRDVRRMRDLGKSIRW 767

Human   775 PLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDY 839
            |.||.||..|......:..||||..::..:||.....:..|:||...|...:::||..|.|..||
 Worm   768 PAPPLVLAQFVSRLRVMHQRWRAATILARMPPHLRASLPQKIAAFEVLNNKKENWGYTRMWRGDY 832

Human   840 LS--SATDNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPD 902
            ||  ...:.||..|.:...::.|:....||.||||::|:|.|:|:|...|.|::||:.:.||: :
 Worm   833 LSQQEELELPTTVSTYHDGIQALRQSHPFGKVLFSTYVQKFNKFNKSSLRVLIVTDRFVAKLE-N 896

Human   903 RQYRVMR-AVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAH-- 964
            ::::::: .:||::::.:||.:..:.|.|:|. |.:|:|.|...::.  :.||||::|.|.||
 Worm   897 KKFKLLKEPIPLQSISRISVCAESNGLFVIHV-GDNDIVGCAKNTKN--EERVGEMIGTLLAHYD 958

Human   965 ----------------CQGEGRTLEVRVSD 978
                            |...|:|..:||.|
 Worm   959 KITMRRSPVLIQSAVVCTLGGKTRTIRVFD 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	383/709 (54%)
		MYSc_Myo1	23..694	CDD:276829	369/678 (54%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		14/21 (67%)
		Myosin_TH1	815..980	CDD:283635	58/185 (31%)
hum-5	NP_497809.1	MYSc	6..699	CDD:214580	384/710 (54%)
		MYSc_Myo1	26..687	CDD:276829	369/677 (55%)
		Myosin_TH1	808..986	CDD:283635	55/181 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161450963
Domainoid	1	1.000	769	1.000	Domainoid score	I39
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	975	1.000	Inparanoid score	I161
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm15994
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2270
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770