Protein Alignment MYO1G and myo1e.1

DIOPT Version :9

• Sequence 1: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Sequence 2: NP_001121497.2
• Gene: myo1e.1 / 100158599
• XenbaseID: XB-GENE-1005591
• Length: 1108
• Species: Xenopus tropicalis
• Alignment Length: 1052
• Identity: 352/1052 - (33%)
• Similarity: 521/1052 - (49%)
• Gaps: 203/1052 - (19%)

Human    10 GKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYER 74
            |..|.|||.::|.:..:.||:.|:....|:||||.||:||||::::|.:|.:.|..|||...||.
 Frog    20 GVDDMVLLSKITEDSIVDNLKKRYMDDFIFTYIGPVLISVNPFKQMPYFGDKEIEMYQGAAQYEN 84

Human    75 PPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLL 139
            |||:||:|:..|:.|.....:.|::||||||||||.|:|:||.||:.|:....:  |:.|||::|
 Frog    85 PPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISKVSGGGPK--VQHVKDIIL 147

Human   140 KSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAF 204
            :|..:|||||||:|.||:||||||||.:|.|...|:|.||.|.::|||||||:.::.|||:||.|
 Frog   148 QSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIF 212

Human   205 YQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALD-SDEQSHQAVTEAMRVIGFSPEE 268
            |||:.|:...|...|.: .:...||:.:|.....:.     | :|::..|....||.|||.|.|.
 Frog   213 YQLIEGASKDQRESLGI-TSLDYYNYLNQSGSYKVD-----DINDKRDFQETMHAMNVIGISAEG 271

Human   269 VESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVAS 333
            ...|.:|:|.:||||||.|  .|:|..    .||..|..:...|.|....:..:...|.:|.:.|
 Frog   272 QAMVMQIVAGVLHLGNIGF--KEKGNY----AAVENEEFLAFPAFLLGINQSRLKDKLTSRQMDS 330

Human   334 --GGR-ELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLD 395
              ||: |.|.......:|.|.|||.:||::.|:|:::|:.||..|       ::|.::..|||||
 Frog   331 KWGGKSESINVTLNVEQACYTRDALSKALHSRVFDYLVDSINKAM-------KKDHEEYNIGVLD 388

Human   396 IYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERP 460
            |||||:|..|.|||||||:.||||||:||:|.||.|||||.:|||.|..:|||||..:.||:|..
 Frog   389 IYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENK 453

Human   461 HR--GILAVLDEACS---SAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHY 520
            ..  |::::||:.|:   :.|...|:..||.|.|....|.|:.|           :.:.|.|.||
 Frog   454 VNPPGVMSILDDVCATMHAVGEGADQTLLQKLQMAVGTHEHFNS-----------WNQGFIIHHY 507

Human   521 AGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMV 585
            ||.|:|.|:||.::|||.||.|...|:.:|..|.::|::|:..|  .|...||.|||:..|....
 Frog   508 AGKVSYDVDGFCERNRDVLFMDLIELMQSSQQPFMQALFPENLQ--AEKKGRPTTAGSKIKKQAN 570

Human   586 ALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLR 650
            .||..|....|.|:|||||||.|.....:|:..:|||.||||.||:||||||:|.|:.:.:||.|
 Frog   571 DLVNTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFKKFLQR 635

Human   651 YKMTCEYTWPNHLLGSDKAAVSALLEQHGLQGD-VAFGHSKLFIRSPRTLVTLEQSRARLIPIIV 714
            |.:..:.|||: ..|.:|..|..||....:..| ...|.:|:||::|.:|..||:.|.|......
 Frog   636 YAILTKETWPS-WKGDEKKGVLHLLHSVNMDSDQFQLGKTKIFIKAPESLFLLEEMRERKYDGYA 699

Human   715 LLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPA 779
            ..:|||||..:||.:                        .:|.|.||:
 Frog   700 RSIQKAWRKYVARKK------------------------YVQMREQAS----------------- 723

Human   780 VLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSAT 844
                      .||...:.|:  :|                          ...|.:..||: ...
 Frog   724 ----------DLFLNKKERR--RN--------------------------SINRNFIGDYI-GMD 749

Human   845 DNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYR--- 906
            :.|.......:|.|          :.|:..|.|.:|..|...|.|:||.:.:|.:..|:..:
 Frog   750 ERPELRQFVGKREK----------IDFADTVTKYDRRSKGVKRDLILTPKSVYLIGRDKMKQGPE 804

Human   907 -------VMRAVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAH 964
                   :.:.:.:|.:..:|:::..|...:||.:..|.|:..|.::         |.:.:|:.|
 Frog   805 KGLVKEVLKKKIDVERILSVSLSTMQDDFFILHEQEYDSLLESLFKT---------EFISLLSKH 860

Human   965 ----------------------------------------CQGEG---------RTLEVRVSDCI 980
                                                    .||.|         :.|:|.:...:
 Frog   861 YEEKTQRKLPLKFNNILDMKLKKENWGPWSGGAGSRQVQFIQGFGDLAVLKHSSKVLQVSIGQGL 925

Human   981 PLSHRGVRRLIS 992
            |.:.|..||.|:
 Frog   926 PKNSRPTRRNIT 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	297/705 (42%)
		MYSc_Myo1	23..694	CDD:276829	286/680 (42%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		10/21 (48%)
		Myosin_TH1	815..980	CDD:283635	33/223 (15%)
myo1e.1	NP_001121497.2	MYSc_Myo1	33..679	CDD:276829	286/680 (42%)
		Myosin_TH1	719..921	CDD:368706	40/276 (14%)
		SH3_MyoIe_If_like	1055..1107	CDD:212761

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920