DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BLK and wnd

DIOPT Version :9

Sequence 1:	XP_011542126.1	Gene:	BLK / 640	HGNCID:	1057	Length:	531	Species:	Homo sapiens
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	95/307 - (30%)
Similarity:	155/307 - (50%)	Gaps:	54/307 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   232 DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANV--MKALQHE 294
            ::|:||.:|:..:..||||..|.|:.|..||. .||:|.:||        |.|.::  ::.|.||
  Fly   152 EDWQIPFESITELEWLGSGAQGAVFSGRLKNE-TVAVKKVKE--------LKETDIKHLRKLDHE 207

Human   295 RLVRLYAVVTKEPIY-IVTEYMARGGAPRRAASSERGGRAGLSRRRRVRC--GCLLDFLKTDEGS 356
            .:::...|.|:.|:: |:.|:                            |  |.|.:.||.::
  Fly   208 NIIKFKGVCTQSPVFCIIMEF----------------------------CPYGPLQNILKEEQ-- 242

Human   357 RLSLP-RLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEG 420
             :.|| ||:..|.|||.||.|:.....|||||::.|||:|.....||:|||.:|.. :|.:.:..
  Fly   243 -VMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREW-NEISTKMS 305

Human   421 AKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPD 484
            ....:.|.|||.|.....:.|.|:||:||:|.|::|. .:||..:.:..:|..: ....::..|.
  Fly   306 FAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPS 369

Human   485 TCPPELYRGVIAECWRSRPEERPTFEFLQSVLE----DFYTATERQY 527
            || ||.::.::..||:|:|..||:|..:.|.|:    :....||:||
  Fly   370 TC-PEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQY 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942
		SH2_Src_Blk	120..219	CDD:198234
		PKc_like	233..522	CDD:304357	91/299 (30%)
		Pkinase_Tyr	241..516	CDD:285015	86/281 (31%)
wnd	NP_649137.3	STYKc	161..400	CDD:214568	86/281 (31%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	87/278 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910