Protein Alignment KIF13A and klp8

DIOPT Version :9

• Sequence 1: NP_071396.4
• Gene: KIF13A / 63971
• HGNCID: 14566
• Length: 1805
• Species: Homo sapiens
• Sequence 2: NP_594675.1
• Gene: klp8 / 2542849
• PomBaseID: SPAC144.14
• Length: 511
• Species: Schizosaccharomyces pombe
• Alignment Length: 486
• Identity: 153/486 - (31%)
• Similarity: 254/486 - (52%)
• Gaps: 71/486 - (14%)

Human     1 MSDTKVKVAVRVRPMNRRELELNTKCVVEMEG-NQTV-LHPPPSNTKQGERK----PPKVFAFDY 59
            ||...|:|.|||||.:.|||..:.:.::.::. |:|| :.||....|....|    .|:.||||.
pombe     1 MSTANVRVIVRVRPKSLRELSKSAEDLLSVDSHNKTVTITPPKHGLKHSRHKNRVNGPRTFAFDE 65

Human    60 CFW-SMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIP 123
            ||. |..||.  ..:|||.|::..|..:::...:|:|:|...|||.|:||::|::|...|.|:||
pombe    66 CFAPSAPESK--NLSGQEDVYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVGLRGQPGIIP 128

Human   124 RLCCALFKRIS--LEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSR-----QSLKVREHKVLGPY 181
            .:..::|:.|.  .:::.:.|..|.:|..||..|...|||.|..:.     :::.|::..:.|.:
pombe   129 HISESIFEEIDKLKKKSPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDSLTGYH 193

Human   182 VDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESS------RSHAVFNIIITQTLYDLQSGN 240
            :.|||:..|.|.::|::.:       .:||.|:..|.|      :.|:||::::.|.:.|.::.:
pombe   194 LHGLSEFEVGSAQEIDAFL-------RLAAKNIRTELSDISGVRKGHSVFSLVVQQRIIDPKTRH 251

Human   241 SGEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPYR 305
            |.:|.|::.::|||...:.|:...:....:..|| ||||:.|..||::|    ..|.....:||:
pombe   252 SLKKASRLQIIDLASFSKGSQRNESISSFESSSN-NKSLSVLNRVIAAL----TSKKNDVLIPYK 311

Human   306 DSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVN-----EDPNAK 365
            |||||.||:|.||||.:|.|:..:||.  ::::|.|.|||::.|:||.|.:.:|     ...|..
pombe   312 DSVLTTLLQDALGGNCRTIMLTCVSPC--DFDDTFSALRYSEAARRIKNISNINCKEAYSTNNEG 374

Human   366 VIRELREEVEKLREQLSQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLES 430
            .:.::...:|..||||.:.|           |.|:||:|.:     |::|...|   ||...|||
pombe   375 ELDDILTTLESDREQLRRHE-----------EHSQKLLKFI-----EEIRNDYE---ERIHALES 420

Human   431 MGISLEMSGIKVGDDKCYLVNLNADPALNEL 461
            ...:|          |.:| .|..|..||.|
pombe   421 QNSAL----------KAHL-RLAVDAYLNPL 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF13A	NP_071396.4	KISc_KIF1A_KIF1B	5..359	CDD:276816	122/373 (33%)
		Kinesin_assoc	356..468	CDD:318424	29/111 (26%)
		FHA	446..543	CDD:238017	7/16 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..575
		SMC_N	<606..771	CDD:330553
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..656
		KIF1B	748..792	CDD:315155
		DUF3694	<1215..1279	CDD:315198
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1385..1404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1507..1531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1612..1645
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1749..1779
klp8	NP_594675.1	KISc	5..354	CDD:276812	118/364 (32%)
		Kinesin	11..356	CDD:278646	116/360 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810