Protein Alignment KIF13A and tea2

DIOPT Version :9

• Sequence 1: NP_071396.4
• Gene: KIF13A / 63971
• HGNCID: 14566
• Length: 1805
• Species: Homo sapiens
• Sequence 2: NP_596620.1
• Gene: tea2 / 2539857
• PomBaseID: SPBC1604.20c
• Length: 628
• Species: Schizosaccharomyces pombe
• Alignment Length: 497
• Identity: 153/497 - (30%)
• Similarity: 247/497 - (49%)
• Gaps: 75/497 - (15%)

Human     9 AVRVRPMNRRELELNTKCVVEMEGNQTV-LHPPPSNTKQGER-------KPPKVFAFDYCF---W 62
            ::|:||:.:               ||.| .|...||...|..       ........:|.|   :
pombe   136 SIRIRPIGK---------------NQGVWSHGKLSNDPYGREYIRQQTSTSSSTIQQEYLFNNVF 185

Human    63 SMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCC 127
            .|:..|..       ::|...:.::...|.|||..:||||.||:||::||.|...:.|:||....
pombe   186 GMESKNYD-------IYKRSVKSVVRNVFSGYNGIVFAYGMTGTGKTYSMQGTENEPGIIPLAMN 243

Human   128 ALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTS 192
            .||:.:. ..::..||::.:||:|||||::|||:.  .|.:..::||:......|..|:::.|||
pombe   244 DLFEMVE-NNSDDDTFQIRISYLEIYNERIRDLIG--NSDEEPRIRENASGEVNVTPLTRVLVTS 305

Human   193 FEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQ---TLYDLQSGNSGEKVSKVSLVDLA 254
            .|::..::.:.|..|..|||:.|..||||||:..:.:.:   |.:..|       :|.:||||||
pombe   306 PEEVSQVIEQCNAIRKTAATDFNTYSSRSHAILQVFLIRNNPTAHTSQ-------ISSLSLVDLA 363

Human   255 GSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQA--AGKGKSKFVPYRDSVLTWLLKDNL 317
            ||||.|   |..||.|||:.|||||.|||.|||.|:..|  :....|..:|||:|.||.||:.:|
pombe   364 GSERAS---AHHERRKEGAFINKSLLTLGTVISRLSAAANPSLTSNSGHIPYRESKLTRLLQQSL 425

Human   318 GGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLS 382
            .|.||.|::||||..:::..||.:||::|.||:.:     ..:...|:.:..::.|:..|...|.
pombe   426 SGQSQISLLATISIESNHTMETTNTLKFASRAQNL-----PQDIRQAEAVTNVQAELASLHSALE 485

Human   383 QAEAMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIK----VG 443
            :.        .:::|....|:|:||...||  |.|.....|.:|   |.|.::..:.::    :.
pombe   486 KN--------AQEVEYYASLVKQLTSDLEE--RDTYIAMLEAER---SQGTAISRARLRMEELLS 537

Human   444 DDKCYLVNLNADPALNELLVYYLK--DHTRVGADTSQDIQLF 483
            |....:.:|..:....|.::|.|:  ...|..||.:|.:..|
pombe   538 DHNFEIADLRDELQDKEQIIYALRYAQKQRDIADFNQSLAKF 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF13A	NP_071396.4	KISc_KIF1A_KIF1B	5..359	CDD:276816	126/365 (35%)
		Kinesin_assoc	356..468	CDD:318424	22/117 (19%)
		FHA	446..543	CDD:238017	9/40 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..575
		SMC_N	<606..771	CDD:330553
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..656
		KIF1B	748..792	CDD:315155
		DUF3694	<1215..1279	CDD:315198
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1385..1404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1507..1531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1612..1645
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1749..1779
tea2	NP_596620.1	Motor_domain	133..460	CDD:277568	126/358 (35%)
		Kinesin	138..459	CDD:278646	126/355 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940