DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLSPN and Claspin

DIOPT Version :9

Sequence 1:NP_071394.2 Gene:CLSPN / 63967 HGNCID:19715 Length:1339 Species:Homo sapiens
Sequence 2:NP_001286934.1 Gene:Claspin / 326205 FlyBaseID:FBgn0052251 Length:1465 Species:Drosophila melanogaster


Alignment Length:1435 Identity:324/1435 - (22%)
Similarity:571/1435 - (39%) Gaps:377/1435 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    53 SKKLKNRKVLQDSDSE---TEDTNASP---------EKTTYDSAEEENKENLYAGKNTKI----- 100
            ||||..::..|:.|.|   ||.....|         :|:..||. .:|:|:  ||::.|:     
  Fly   221 SKKLAKKQKQQEDDKEDNGTEQEKKKPSPKSKAKKSDKSKIDSL-MDNEED--AGEDLKMYQEDQ 282

Human   101 --------KRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHD 157
                    |...||..||.|...|...:||    |.||..::.|.:       .|.|..|:.|..
  Fly   283 EPQKQKTKKSAKKTNKDSKEESGEDQEHQE----QKKPLKKIKLDN-------IDTKEDKEQIVK 336

Human   158 KEGTAGKAKVKSKRRLEKEERKMEKIRQ---LKKKETKN--------QEDDVEQPFNDSGCLLVD 211
            .:..|.|.|.|.....|.||.:.||:.|   |||..::|        ::.::::|...:   ..:
  Fly   337 PKKMAKKNKQKVLSDDESEENQNEKVDQDHDLKKMSSENELEMGSDKEDQEMQEPPKKA---KKN 398

Human   212 KDLFETGLEDE---------NNSP-----------LEDEESLESIRAAVKNKVK--KHKKKEPSL 254
            |...::..|||         .:||           .|.||:.|.: :.||||:|  ...:.||.|
  Fly   399 KQRMDSESEDEIPKTESEKITSSPKNKLKGLVDSESEPEETAEEV-SPVKNKLKGLVDSESEPEL 462

Human   255 ESGVHSF-EEGSELSKGTTRKERKAARLSKEALKQ-------LHSETQRLIRESALNLPYHMPEN 311
            ::...|. |:.:.:....:|::.|.|::.:|:.|:       :.||.|||.||:.:|:|||.|:.
  Fly   463 DNPEESAGEQEAPMESALSREKPKKAKVVRESAKKALEGMQAIQSEQQRLHREAHINVPYHQPKP 527

Human   312 KTIHDFFKRK--------------PRPTCHGNAMALLKSSKYQ-SSHHKEIIDTAN------TTE 355
            :|:.:|..|:              |.|:........|:.::.: .::.|.:.|.|.      .:|
  Fly   528 RTLKEFLSRRTINAPLATALAGGSPMPSRQPRKSVGLRMTREELEAYAKLMEDRAKEATEFFKSE 592

Human   356 MNSDH------------------------HSKGSEQTTGAENEVETNA---LPVVSKETQIITGS 393
            ..||.                        :.|..||......::.:.|   :||:.::....|..
  Fly   593 SESDEEDDSENEEPMELKDNPGVMDEMLDNPKTPEQPKNDTEDMTSQAVIEVPVLGEDKTDDTVG 657

Human   394 DESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEG 458
            ||:...|.:..|| .|......:.::.:  |:..:|||:|  ..:.|:.|.|             
  Fly   658 DEAMVADSITEEE-PIASTSTAAALKLA--DNFEIQQETN--AKSPSKVCLV------------- 704

Human   459 EGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDR-LKQLGVDVSI--KPRLGADEDSFVIL 520
                     .|.||.|:....:..:.|..|.....:.. ::||.::.|:  .|.|..|.:..:.|
  Fly   705 ---------TEVVELPKLDLSTINITPSSKPATPKISEVIRQLKIEKSLDESPSLKGDPNMVIDL 760

Human   521 E-----PETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTD-GKEELKADVVPVTLAP 579
            |     .:....::.|..|..| ...|.|.:..:|||:      :.|: ||.|:..  |.:.|..
  Fly   761 ETGDMFAKKPTGVDDLLNRLMK-TREAKKHKTTETVNI------LTTEHGKLEMSK--VSIHLHE 816

Human   580 KKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEE 644
            :::  |...|||.....::..|:..:..:|.|:.:|:||              ||:|:|.::.||
  Fly   817 EEI--AKEPKPGAGYMKMQEHLKTLITKKRMEDLRKKQA--------------EEQEKMAEDEEE 865

Human   645 --DGEEKVEKEEK----EEELEEEEE----KEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKEN 699
              |.:|:.|.|:|    |..:.|:||    .:...|::|:.|           |.|::.:.|.|:
  Fly   866 GMDVDEEYEPEDKPGYAEVTINEDEEIIDKVDSTAEDDGDAE-----------ENKNDADEDPED 919

Human   700 NDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCS 764
            |               |...|.|.     |:.|..........:.||......:..|..|||   
  Fly   920 N---------------PVEDSEDE-----KNDSESEQECEANPEPETQTRKKNRIIKAFEDD--- 961

Human   765 LLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFP-TAGGFRSPSPGLFRASLVSSASKSSGK 828
                 :|.....:|:            ||.:.::..| ||...:..:..||......:||....:
  Fly   962 -----NSDEDDLDLL------------QTPKPSNVAPITATQLQLSAHKLFDVETRRTASDEENE 1009

Human   829 LSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPR 893
            |                      |.|.:|.|       .|:|:|.:|.       .:...|:..:
  Fly  1010 L----------------------LDLCSGQF-------PQTQMLSSDA-------PSVDTAVISQ 1038

Human   894 LPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQD------ 952
            :|:.....::..|  |||..||:|.|.:|.....|.:..:::...|:....:.:..|.|      
  Fly  1039 IPMTQFGGSSQAA--DELEGLCSGTFATQLPSQAPTQQPEQQEESEVPAAVANRIVSSDEEAQED 1101

Human   953 ---ASTPASSELNKQ--EKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDS 1012
               ...|.:.:|.|:  :|::.:|             |..|::.:||.|||        |.|.|:
  Fly  1102 ALEVDKPRNKKLTKKRPKKKAKLG-------------FSDDEDSDDEVEEF--------DEESDA 1145

Human  1013 DEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEID 1077
            :..|....    ...|: |.:|.|::....|..|::|...:::.|||:|.|:.||.|| |.:.:|
  Fly  1146 EPVEEIPE----TFVDY-DSEENEIVVEMTKKDRKIRAANFVDKEAELSESEWGSADE-DEKNMD 1204

Human  1078 EYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKN 1142
            ||:.::.||.....::|:.::.:||.:.|:|.|.|::|..:|....:   ..:|..|.|:|||||
  Fly  1205 EYDIELGDEDQFDRDKLRHELGQIHARKMMDQDIREVRKIKELLFEE---EEEGANRQRQFRWKN 1266

Human  1143 IDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDS--- 1204
            ::....:|....|:.:.......:|:|..|||.|.||||.|.:...:.::.:.....:...|   
  Fly  1267 VEAGFSLDDNRTDNGEGNDGSGDEENEHLWRKIRYEREQLLLEKGLKPEVASPLSTSVINTSNNG 1331

Human  1205 ------QFMILAKKVTAKALQKNA----SRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQP 1259
                  :..|::.|.|...::||:    |:.:..::.||.:|                ||.|.:.
  Fly  1332 NSPAIRRLNIISSKKTTVEVKKNSPFLISKTIAGKQQKSAVR----------------GSFLIRD 1380

Human  1260 KAVLQKLAALSDHNPS-----------APRNSRNFVFHTLSPVKAEAAKESSK---SQVKKRGPS 1310
            :..|.|||.|:.....           ....::||||.||:..:.|..|..:.   :...:.|.:
  Fly  1381 QQTLSKLAGLTKGTSGDVDAAEGTISVKSAKAKNFVFATLTEEEHENRKRKAADILNSSTETGVN 1445

Human  1311 FMTSP 1315
            |:..|
  Fly  1446 FIKKP 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLSPNNP_071394.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96 16/54 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..204 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..285 10/44 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..490 33/187 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..707 24/98 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..774 8/43 (19%)
CKB motif 1 910..919 5/8 (63%)
CKB motif 2 939..948 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..973 7/37 (19%)
CKB motif 3 976..985 0/8 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 985..1075 28/89 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1327 5/25 (20%)
ClaspinNP_001286934.1 infB 58..>180 CDD:177089
2A1904 <96..411 CDD:273344 54/206 (26%)
MDN1 <861..947 CDD:227596 25/116 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152596
Domainoid 1 1.000 192 1.000 Domainoid score I3213
eggNOG 1 0.900 - - E1_KOG4156
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 193 1.000 Inparanoid score I3853
Isobase 1 0.950 - 0 Normalized mean entropy S8226
OMA 1 1.010 - - QHG47598
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007571
OrthoInspector 1 1.000 - - oto91724
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR14396
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7986
SonicParanoid 1 1.000 - - X7601
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.840

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