Protein Alignment Ube4b and Ube4B

DIOPT Version :10

• Sequence 1: NP_001391798.1
• Gene: Ube4b / 63958
• MGIID: 1927086
• Length: 1465
• Species: Mus musculus
• Sequence 2: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Alignment Length: 1249
• Identity: 444/1249 - (35%)
• Similarity: 659/1249 - (52%)
• Gaps: 161/1249 - (12%)

Mouse   291 PSFALPSHPAP--QAAMPSQSLSPHGVAPQAAVPSQSLSPHGVAPQAAVPSQSLSPHGVAPQVAV 353
            |...||..|.|  |...|::|:.   |...:|...::.....:|.::.:..      .:||....
  Fly    46 PGQQLPEQPNPDVQPQQPAESVV---VTELSAEEMRARRLRTLAARSGIQC------ALAPLTTT 101

Mouse   354 PSQSLSTHGVA--PQAAVPSQ---SLSTHGVA-------PQAAVPSQSLSTHGVAPQVAVPSQ-- 404
            |.:..:..|.:  .:.|.|.:   ||.|...|       |...|..:|:        |:.|.|
  Fly   102 PRKPTNVSGESRLVREATPGEKEVSLPTSAPAWRELSGKPDMDVEMKSV--------VSTPMQDV 158

Mouse   405 ------SLSTHGVAPQAAVPSPPLSPHSTASGNA-------AGSQPSSPRYRPYTVT-------H 449
                  ||.|.....::.:.|..:|     :|||       .|.:.|:.......::       :
  Fly   159 DMTTALSLPTAEATKRSVLQSCKIS-----AGNAELSIETVVGPKKSADEQNEQLLSRLLNATWN 218

Mouse   450 PWGSSPCPTPRSSILASSPGFPSHASSPRAVPASSSRQRPRSRVPAFPPASPSAASRRPSSLRIS 514
            .:||.      |.|.|.|              ||...|:|..|   |......|.....:.|:|
  Fly   219 EYGSG------SIICAQS--------------ASFLEQQPHRR---FDFECIVANVLMEAVLKI- 259

Mouse   515 PSMSNSPFSFLFLELSGDSSDDDEEE---------DEEELDE--------GGGDDDFSYVQFGSS 562
                   ::...:|..|.|...|::|         |:.|:.|        ||.      ...|.:
  Fly   260 -------YNGELIEGDGVSVKADDKEFSSAKKIKSDDTEVQEILANAVATGGA------TASGET 311

Mouse   563 LGASGGASNWDSYSDHFTIETCKETDMLN-----------YLIECFDRVGIE-EKKAPKMCSQPA 615
            ..|:.|||.....:......||....:|:           |||.|:.....| .:|.|  .:|||
  Fly   312 AAAAAGASGPIEATSSEAAGTCVAPPVLSIVATTKHHVLLYLIRCYQNYQTECSRKTP--LTQPA 374

Mouse   616 VSQLLSNIRSQCISHTALVLQGSLTQP-RSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVF 679
            :....    .|.:..|.|||...:.|. ......|.|:..|....:...|:.:|:..||||.|.|
  Fly   375 LQLAF----EQVMRMTVLVLTDRIYQNLNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQDREAF 435

Mouse   680 KQIFIPILQGLALAAKECSLESDYFKYPLMALGELCETKFGKTHPMCNLVASLPLWLPKSLSPGS 744
            ..||..:|:||....:.....|......:..|.:|...|.|...|:.:||:..|.:||...:..|
  Fly   436 DTIFSQVLRGLFAGMQRNICTSKISVQQIEWLSKLVVIKVGSVRPIADLVSRQPNFLPPICTKIS 500

Mouse   745 GRELQRLSYLGAFFSFSVFAEDDAKVVEKYFSGPAITLEN--TRVVSQSLQHYLELGRQELFKIL 807
            |||:.:.|:||.|.|.|:|||::.|..|       .|.:|  ....|..|:..|...|..:..:.
  Fly   501 GREIVKCSFLGPFLSVSLFAEENIKFAE-------FTTKNKLEDASSSRLRWELHSMRTNMHVVF 558

Mouse   808 HSILLNGETREAALSYMAALVNANMKKAQMQADDRLVSTDGFMLNLLWVLQQLSTKIKLETVDPT 872
            ||:.:|..:|...|.|:|:::..|.::.|..:|::|::.||||:||:.||||||.||||:.::|.
  Fly   559 HSLCVNASSRPKTLEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDRIEPN 623

Mouse   873 YIFHPRCRITLPNDETRINATMEDVNERLTELYGDQPPFSEP----KFPTECFFLTLHAHHLSIL 933
            :.::....:.:..| |:|..:.|:....|..      .||:|    .|.|:|:||||.||||..|
  Fly   624 FHYYKNSLVNIEQD-TKIRYSEEEYRNFLAR------DFSQPVENTNFQTQCWFLTLQAHHLGYL 681

Mouse   934 PSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLL 998
            |:.:||.:::|||:||.:.:::|...:|.|.:|..|.|:.:..:|.:.||:||.|.|.|.:..||
  Fly   682 PAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLL 746

Mouse   999 DESFLRRCLNFYGLLIQLML-----RILDPAYPDVTLPLNSEVP-KVFAALPEFYVEDVAEFLFF 1057
            |...|:||..||..:.:.||     |.::..:.. .||:...:| ..|:||||:|::|:|||:.|
  Fly   747 DPGLLQRCTEFYSTVCEFMLYQFEGRPIEGPFIS-KLPVQQLLPTDAFSALPEWYIDDIAEFILF 810

Mouse  1058 IVQYSPQVLYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENH 1122
            .:|::...:.:.....|:.:|:..:|..:.|:|||:.||||||||:.  |::|.......| .||
  Fly   811 TMQHANMDIRQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVF--SLKPANSVNAAM-WNH 872

Mouse  1123 PLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFV 1187
            .|:...||.|||:||.|||.||.::|||||||||||||.:|||:|:|..|....:.|...|.|||
  Fly   873 ELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICESRVGNQFV 937

Mouse  1188 RYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLAL 1252
            :::|||:|||||||||.||:|||||:.|:.:.:|....::..:|||:|.:|||.|||..||||.|
  Fly   938 KFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTL 1002

Mouse  1253 ATETVDMFHLLTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQ 1317
            |.||||:||.||..:::||:|.||..||::||||||:||.||||.||||:||.|||:||:.||.|
  Fly  1003 ARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQ 1067

Mouse  1318 LTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNA 1382
            :.||||.|||.|||:|:|.|:||:..::..|..|::::..::|.:.:|:||.|.::..||...|.
  Fly  1068 IFDIYLHLDCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAHEIYVTNL 1132

Mouse  1383 RAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTVMDRSIILRHLLNSPTDPFNRQMLTESMLEPVP 1447
            :.|.:.:||||||:||||||||:|||.|||||||||:||.||||||.|||||||.|||.||....
  Fly  1133 QTEDECADAPDEFKDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTEDMLVANI 1197

Mouse  1448 ELKEQIQAWMREKQ 1461
            |||::|.||.:|::
  Fly  1198 ELKQRIDAWRKEQR 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4b	NP_001391798.1	PHA03247	<296..521	CDD:223021	50/260 (19%)
		Ufd2P_core	754..1374	CDD:463080	269/631 (43%)
		RING-Ubox_UBE4B	1388..1461	CDD:438320	53/72 (74%)
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	269/631 (43%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	53/72 (74%)