Protein Alignment GALNT11 and Pgant35A

DIOPT Version :9

• Sequence 1: NP_001358393.1
• Gene: GALNT11 / 63917
• HGNCID: 19875
• Length: 667
• Species: Homo sapiens
• Sequence 2: NP_652069.2
• Gene: Pgant35A / 48775
• FlyBaseID: FBgn0001970
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 256/602 - (42%)
• Similarity: 345/602 - (57%)
• Gaps: 91/602 - (15%)

Human     7 RYFCYGC----LFTSATWTVLLFVYFNF--------------------------SEVT---QPLK 38
            |..|..|    |..:..|.:.|..|.:.                          :.||   .|..
  Fly     6 RLLCKSCGLGTLLVAVVWLLALLFYSHSLRSSIRSAGWRIDEGNATPRAELSYQARVTVGCTPNA 70

Human    39 NVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFN 103
            :: ..|..|..|.|          ||                     |||:..|     ||::.|
  Fly    71 SI-TTGESPAAPKP----------PS---------------------DPEQLEL-----LGVVRN 98

Human   104 ERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAAC--KEKFYPPDLPAASVVICFYNEAFSA 166
            ::|:.:||:||:.||||.|:|:.:|..|.:||||:..|  :|.....:||.||:|:|||||....
  Fly    99 KQDKYIRDIGYKHHAFNALVSNNIGLFRAIPDTRHKVCDRQETTEAENLPQASIVMCFYNEHKMT 163

Human   167 LLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLK----GELDEYVQKYLPGKIKVIRNTKREGLIR 227
            |:|::.:|::|||::||.|||||||.||..:|:    |:|...: ||  ..::.|:|.:||||||
  Fly   164 LMRSIKTVLERTPSYLLREIILVDDHSDLPELEFHLHGDLRARL-KY--DNLRYIKNEQREGLIR 225

Human   228 GRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRG 292
            .|:|||..|.|:||||||||.|||..||:|||..|:.:..|:..||||:|:|||..|:.||:|||
  Fly   226 SRVIGAREAVGDVLVFLDSHIEVNQQWLEPLLRLIKSENATLAVPVIDLINADTFEYTPSPLVRG 290

Human   293 GFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEI 357
            ||||||||:|:.:|...|...|....|.:||||||||||:||:||..||:||..||||||||:||
  Fly   291 GFNWGLHFRWENLPEGTLKVPEDFRGPFRSPTMAGGLFAVNRKYFQHLGEYDMAMDIWGGENIEI 355

Human   358 SFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLK 422
            |||.|.|||.:.|:|||||||||||||||.||:|.:||..|||||||||:|:||:.|.......|
  Fly   356 SFRAWQCGGAIKIVPCSRVGHIFRKRRPYTSPDGANTMLKNSLRLAHVWMDQYKDYYLKHEKVPK 420

Human   423 TKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQ--QPIFVNRGPKRPKVLQRGRL 485
            |..||:||:|::||::|.|:.|.|||.|||||:.:.|..:|..  .|||.....::...:...:|
  Fly   421 TYDYGDISDRLKLRERLQCRDFAWYLKNVYPELHVPGEESKKSAAAPIFQPWHSRKRNYVDTFQL 485

Human   486 YHLQTNKCLVAQGRPS-----QKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSS 545
            ....|..| .|...|.     :||..:.|:.|..: |||:|...|:.|:||:.||||:.|   ..
  Fly   486 RLTGTELC-AAVVAPKVKGFWKKGSSLQLQTCRRT-PNQLWYETEKAEIVLDKLLCLEAS---GD 545

Human   546 DPPRLMKCHGSGGSQQW 562
            ....:.|||...|.|||
  Fly   546 AQVTVNKCHEMLGDQQW 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		62/114 (54%)
		pp-GalNAc-T	154..452	CDD:133004	173/301 (57%)
		Catalytic subdomain B	319..381		45/61 (74%)
		Ricin_B_lectin	483..>564	CDD:366226	29/85 (34%)
Pgant35A	NP_652069.2	pp-GalNAc-T	151..450	CDD:133004	173/301 (57%)
		RICIN	489..610	CDD:214672	28/79 (35%)
		RICIN	490..609	CDD:238092	28/78 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I3040
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11126
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1502
Isobase	1	0.950	-	0	Normalized mean entropy	S4020
OMA	1	1.010	-	-		QHG50170
OrthoDB	1	1.010	-	-		D367513at33208
OrthoFinder	1	1.000	-	-		FOG0006575
OrthoInspector	1	1.000	-	-		oto90263
orthoMCL	1	0.900	-	-		OOG6_108745
Panther	1	1.100	-	-	LDO	PTHR11675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4588
SonicParanoid	1	1.000	-	-		X5575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820