Protein Alignment GALNT11 and Pgant6

DIOPT Version :10

• Sequence 1: NP_001358393.1
• Gene: GALNT11 / 63917
• HGNCID: 19875
• Length: 667
• Species: Homo sapiens
• Sequence 2: NP_647749.2
• Gene: Pgant6 / 38346
• FlyBaseID: FBgn0035375
• Length: 666
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 222/627 - (35%)
• Similarity: 315/627 - (50%)
• Gaps: 109/627 - (17%)

Human    14 LFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHG--PSPKKF---------YPRFTR-GPSRV 66
            |..|.|..||:..:.:    :.|..|.||.    ||  |.|:|.         .|...: .|.:.
  Fly    16 LLISLTLFVLITSWIS----STPYTNKPVH----HGVEPVPEKAGLSGDVKVKVPAIKQPEPQKP 72

Human    67 LEPQFKAN----KID--DVIDSRVEDP----EEGHLKFSSELGM---------------IFNER- 105
            .||.|:.:    |||  :.::..|::|    :|...:...||.|               .|.|:
  Fly    73 QEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKD 137

Human   106 ----------------DQELRDLGYQ---KHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLP 151
                            |:..|||..:   ::.||.|:||.:..:|.|||.|:..|::|.|...||
  Fly   138 AKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLP 202

Human   152 AASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKV 216
            ..||:|.||||..|.|:|:|||:|:|:|..|:.|||||||.||.:.|..||:.|:.::... ::|
  Fly   203 TVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKW-VRV 266

Human   217 IRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADT 281
            :|..:|.|||..|..||.:||.|||:|||||.|.|..||.|||..|..::.|.|||.||:|....
  Fly   267 VRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTN 331

Human   282 LAY-SSSPVVRGGFNWGLHFK-WDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYD 344
            ..| :.....||.|:|...:| ..|:|......|:    |.|||.|||||||::|::|.|||.||
  Fly   332 FHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPAD----PFKSPIMAGGLFAISREFFWELGGYD 392

Human   345 SGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFR-KRRPYGSPEGQDTMTHNSLRLAHVWLD 408
            .|:||||||..|:||:||||||:::..||||:|||:| .|....||...|.:..|..|:|.||:|
  Fly   393 EGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMD 457

Human   409 EYKEQYFSLRPDL-KTKSYGNISERVELRKKLGCKSFKWYLDNV-------YPEMQISGSHAKPQ 465
            |||...:|....| ::...|:::|:..:|.||.||||||:::.|       ||
  Fly   458 EYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYP------------ 510

Human   466 QPIFVNRGPKRPKVLQRGRLYHL-QTNKCLVAQGRPSQKGGLVVLKAC--DYSDP--NQIWIYNE 525
                    |..|.....|.|.:: ..|.||...||  :|...:.:.||  :...|  .|.|..:.
  Fly   511 --------PVDPPSYAMGALQNVGNQNLCLDTLGR--KKHNKMGMYACADNIKTPQRTQFWELSW 565

Human   526 EHELVL-NSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGY 566
            :.:|.| ....|||:....::.|..|..||..||:|.|.:.|
  Fly   566 KRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDY 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		58/110 (53%)
		pp-GalNAc-T	154..452	CDD:133004	142/308 (46%)
		Catalytic subdomain B	319..381		41/61 (67%)
		beta-trefoil_Ricin_GALNT11	478..>565	CDD:467318	26/92 (28%)
Pgant6	NP_647749.2	pp-GalNAc-T	205..502	CDD:133004	141/301 (47%)
		beta-trefoil_Ricin_Pgant9-like	515..648	CDD:467340	27/95 (28%)