Protein Alignment GALNT11 and Pgant3

DIOPT Version :10

• Sequence 1: NP_001358393.1
• Gene: GALNT11 / 63917
• HGNCID: 19875
• Length: 667
• Species: Homo sapiens
• Sequence 2: NP_610256.1
• Gene: Pgant3 / 35627
• FlyBaseID: FBgn0027558
• Length: 667
• Species: Drosophila melanogaster
• Alignment Length: 606
• Identity: 215/606 - (35%)
• Similarity: 319/606 - (52%)
• Gaps: 75/606 - (12%)

Human    22 VLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVED 86
            :|.|.:|.|: ::..|....::|.......||....|.:..|.:.:...:...  .|:..:...|
  Fly    18 LLFFAFFMFA-ISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGK--GDIFGNMTAD 79

Human    87 PEEGHLKFSSELG-------MIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEK 144
            ....:| |....|       ::...||:......::.::||:|.|||:..:|.:.|.|...|::|
  Fly    80 DYNINL-FQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDK 143

Human   145 FYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKY 209
            .|...||:.||:|.|:|||:|.||||:.|||:|:|.|||.|||||||.||...||.:|:.|| |.
  Fly   144 KYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYV-KV 207

Human   210 LPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVI 274
            |....::.|..||.||:..|::||.:|.|:||.|||:|||.:..||:|||:.|:|.|..|:||||
  Fly   208 LAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVI 272

Human   275 DIISADTLAYSSSPVVR-GGFNWGLHFKW---DLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQ 335
            ||||.|..:|:.:.... |.|||.|.|:|   |....:....::.:|.||.:|.|||||||::|:
  Fly   273 DIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRK 337

Human   336 YFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEG-QDTMTHNS 399
            ||:|:|.|||.|.:|||||:|:|||||.|||::.|.|||.|||:||...||..|.| .:.:|.|.
  Fly   338 YFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNL 402

Human   400 LRLAHVWLDEYKEQYFSL----RPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPE------ 454
            .|.|.||:|::  |||.:    ...|..|...|::|||.||::|.||.|.|||:|::||
  Fly   403 ARAATVWMDDW--QYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAP 465

Human   455 ----------------MQISGSHAKPQQPIFVNRGPKR------PKVLQRGRLYHLQTNKCLVAQ 497
                            .|....|.|......::|..||      .|..:...|..|:.:|||
  Fly   466 DRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCL--- 527

Human   498 GRP-------SQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCL----------DMSETRSS 545
             ||       |....:.|.....::....:::...:.:::.|..:||          .|.:.|::
  Fly   528 -RPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNA 591

Human   546 DPPRLM--KCHGSGGSQQWTF 564
            ....:|  :| .|..||.||:
  Fly   592 TTSNVMLAQC-ASDSSQLWTY 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		61/110 (55%)
		pp-GalNAc-T	154..452	CDD:133004	154/306 (50%)
		Catalytic subdomain B	319..381		40/61 (66%)
		beta-trefoil_Ricin_GALNT11	478..>565	CDD:467318	22/106 (21%)
Pgant3	NP_610256.1	pp-GalNAc-T	153..457	CDD:133004	154/306 (50%)
		beta-trefoil_Ricin_Pgant3-like	515..661	CDD:467338	21/102 (21%)