DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GALNT11 and Pgant2

DIOPT Version :9

Sequence 1:	NP_001358393.1	Gene:	GALNT11 / 63917	HGNCID:	19875	Length:	667	Species:	Homo sapiens
Sequence 2:	NP_608773.2	Gene:	Pgant2 / 33556	FlyBaseID:	FBgn0031530	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	225/513 - (43%)
Similarity:	296/513 - (57%)	Gaps:	62/513 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    88 EEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPA 152
            |.|:::    .|.:.|..|.      |.::.||...||.|..:||:|||||..|:.|.|..|||.
  Fly   149 EAGYIR----AGALRNGEDP------YIRNRFNQEASDALPSNRDIPDTRNPMCRTKKYREDLPE 203

Human   153 ASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVI 217
            .||:|.|:|||.|.||||:.||::|:|.||:.||:||||.||..:...||.:.      .|::||
  Fly   204 TSVIITFHNEARSTLLRTIVSVLNRSPEHLIREIVLVDDYSDHPEDGLELAKI------DKVRVI 262

Human   218 RNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTL 282
            ||.|||||:|.|:.||..|...||.|||||.|.|.|||:|||..:|||...|||||||:||.|..
  Fly   263 RNDKREGLVRSRVKGADAAVSSVLTFLDSHVECNEMWLEPLLERVREDPTRVVCPVIDVISMDNF 327

Human   283 AY-SSSPVVRGGFNWGLHFKWD-LVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDS 345
            .| .:|..:||||:|.|.|||: |.|.....|....|..|::|.:|||||.:::.||::||:||.
  Fly   328 QYIGASADLRGGFDWNLIFKWEYLSPSERAMRHNDPTTAIRTPMIAGGLFVIDKAYFNKLGKYDM 392

Human   346 GMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQ-DTMTHNSLRLAHVWLDE 409
            .||:|||||||||||:|.|||.|.|||||||||:||||.||..|.|. :....|:.|.|.||:|:
  Fly   393 KMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYTFPGGSGNVFARNTRRAAEVWMDD 457

Human   410 YKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQ-------- 466
            ||:.|::..|..|...:|||.:|:.|::||.||.|||||:||||::|.    ..||:
  Fly   458 YKQHYYNAVPLAKNIPFGNIDDRLALKEKLHCKPFKWYLENVYPDLQA----PDPQEVGQFRQDS 518

Human   467 ------------------PIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACD 513
                              |.....|.:.....:||.:.|......||...|.||    |||||||
  Fly   519 TECLDTMGHLIDGTVGIFPCHNTGGNQEWAFTKRGEIKHDDLCLTLVTFARGSQ----VVLKACD 579

Human   514 YSDPNQIWIYNE----EHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGYF 567
            .|: ||.||..|    .|..:   .:||| |..:|........|:.:.|:|:|:||.:
  Fly   580 DSE-NQRWIMREGGLVRHYKI---NVCLD-SRDQSQQGVSAQHCNSALGTQRWSFGKY 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		60/110 (55%)
		pp-GalNAc-T	154..452	CDD:133004	160/300 (53%)
		Catalytic subdomain B	319..381		40/61 (66%)
		Ricin_B_lectin	483..>564	CDD:366226	30/84 (36%)
Pgant2	NP_608773.2	WcaA	200..>432	CDD:223539	133/237 (56%)
		pp-GalNAc-T	205..500	CDD:133004	160/300 (53%)
		Ricin_B_lectin	511..627	CDD:279046	32/124 (26%)
		RICIN	513..629	CDD:238092	33/124 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820