Protein Alignment SDHB and SdhB

DIOPT Version :10

• Sequence 1: NP_002991.2
• Gene: SDHB / 6390
• HGNCID: 10681
• Length: 280
• Species: Homo sapiens
• Sequence 2: NP_477101.1
• Gene: SdhB / 35590
• FlyBaseID: FBgn0014028
• Length: 297
• Species: Drosophila melanogaster
• Alignment Length: 280
• Identity: 194/280 - (69%)
• Similarity: 234/280 - (83%)
• Gaps: 4/280 - (1%)

Human     1 MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDL 65
            ::.|.:|..|.::.|.:.|.|  |..:.||...|..|:||||.||||:||.||:||:||||||||
  Fly    10 LSRVGSLVARNQMRAISNGTA--QLEQQAQPKEAQEPQIKKFEIYRWNPDNAGEKPYMQTYEVDL 72

Human    66 NKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPL 130
            .:|||||||||||||||:|.||||||||||||||||||||.|.|||||..:||.|.:|..|:|||
  Fly    73 RECGPMVLDALIKIKNEMDPTLTFRRSCREGICGSCAMNIGGTNTLACISKIDINTSKSLKVYPL 137

Human   131 PHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQE--GKQQYLQSIEEREKLDGLYECILCACCS 193
            |||||::|||||::|||.||::|:|:|::|:|:.|  ||.|||||:|:|.|||||||||||||||
  Fly   138 PHMYVVRDLVPDMNNFYEQYRNIQPWLQRKNEAGEKKGKAQYLQSVEDRSKLDGLYECILCACCS 202

Human   194 TSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLN 258
            |||||||||.:||||||||||||||:|||||:.:.|||.||:||||:||||||||||||||||||
  Fly   203 TSCPSYWWNAEKYLGPAVLMQAYRWIIDSRDENSAERLNKLKDPFSVYRCHTIMNCTRTCPKGLN 267

Human   259 PGKAIAEIKKMMATYKEKKA 278
            ||:|||||||:::....|.|
  Fly   268 PGRAIAEIKKLLSGLASKPA 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDHB	NP_002991.2	PLN00129	5..271	CDD:215067	191/267 (72%)
		Interaction with SDHAF1. /evidence=ECO:0000269|PubMed:26749241	146..218		55/73 (75%)
SdhB	NP_477101.1	PLN00129	6..279	CDD:215067	192/270 (71%)