Protein Alignment VIPAS39 and Vps16B

DIOPT Version :10

• Sequence 1: NP_071350.2
• Gene: VIPAS39 / 63894
• HGNCID: 20347
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_651731.1
• Gene: Vps16B / 43521
• FlyBaseID: FBgn0039702
• Length: 447
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 131/502 - (26%)
• Similarity: 209/502 - (41%)
• Gaps: 86/502 - (17%)

Human     7 DEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDFVDDD--DDDDLERVSWSGEPVGSISW 69
            |.|.|||.|...||:|||||:           |:...|.|.:.  .||.:...|::...  :::.
  Fly     6 DSESYWNRSSRAAFSFDDEDE-----------VDLAPDLVSNGILADDTISEASFNNSV--ALNL 57

Human    70 SIRETAGNSGSTHEGREQ-LKSRNSFSSYAQLPKPTSTYSLSSFFRGRTRPGSFQSLSDALSDTP 133
            ||:............:|| |..|       .|||..|........|        :.|...|
  Fly    58 SIKSILSEEALKLVLQEQALDDR-------VLPKGVSPEEELKLLR--------RQLQSTL---- 103

Human   134 AKSYAPELGRPKGEYRDYSNDWSPSDTVRRLRKGKVCSLERFRSLQDKLQLLEEAVSMHDGNVIT 198
               |:|.|                ..|.::|.:||...||.|:||.:|.|||:..::...|:.:.
  Fly   104 ---YSPNL----------------EATAQKLLQGKTAPLEMFKSLHEKQQLLDTLMAQGGGHAVI 149

Human   199 AVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLN 263
            .||:||||||:.......|..|..||...:.:|||.||....::|.:...|.:|.||..::..|.
  Fly   150 TVLLFLKRTLNTTQFHGILRERPKALEQYLSYLKESGDLAGHIELLQLFGRHQEAALKQFQAALA 214

Human   264 IQDPDKRKEFLKTCVGLPFSAEDSAHI-------QDHYTLLERQIIIEANDRHLESAGQTEIFRK 321
            ..|...||:.|:..|    .|..:|.:       |..:..|:.|.::|      :.:...::.|.
  Fly   215 SGDTSTRKKHLQLLV----DAYATAGVGVIPLYEQVFHAALKMQQLME------KDSALGKLLRD 269

Human   322 HPRKASILNMPLVTTLFYSCFYHYTEAEGTFSSPVNLKK---TFKIPDKQYVLTALAARAKLRAW 383
            .|..        |..|:..|..:....|.....||:.::   ..:|...||..|||..||:.:|:
  Fly   270 QPTP--------VEVLYACCQVNSNWKEQDMLKPVSPQRFAADQQISPAQYEWTALNERAQAQAY 326

Human   384 NDVDALF-TTKNWLGYTKKRAPIGFHRVVEI--LHKNNAPVQILQEYVNLVEDVDTKLNLATKFK 445
            .|::.:| ...:|.....|:..|.|...:.:  |::..||..:||.:::.:.:...||.||.:.|
  Fly   327 ADLECIFERVPSWHPLKTKQFHISFDLTLAVLRLYELQAPSTVLQLFLSKMGNSVEKLALAQRVK 391

Human   446 CHDVVIDTYRDLKDRQQLLAYRSKVDKGSAEEEKIDALLSSSQI-RW 491
            |...|||....||.:|:|...:..:.:.|.|:...:..|.|.|. ||
  Fly   392 CIKAVIDAMAGLKQQQELQQLKDTLPERSEEQFYCENALKSLQSKRW 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VIPAS39	NP_071350.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..99		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..152		5/28 (18%)
Vps16B	NP_651731.1	Vps16_C	148..>235	CDD:282668	29/90 (32%)