Protein Alignment THADA and TRM732

DIOPT Version :10

• Sequence 1: NP_071348.3
• Gene: THADA / 63892
• HGNCID: 19217
• Length: 1953
• Species: Homo sapiens
• Sequence 2: NP_013986.1
• Gene: TRM732 / 855301
• SGDID: S000004872
• Length: 1420
• Species: Saccharomyces cerevisiae
• Alignment Length: 1698
• Identity: 341/1698 - (20%)
• Similarity: 627/1698 - (36%)
• Gaps: 479/1698 - (28%)

Human   324 SMGRSGEALLLDTAHVLFTLSSQI---KEPTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGN 385
            ::..|...:..||..:....|.||   |:...:.|||.:              ....||::   |
Yeast    58 NLNESTRLIFPDTFSICLLRSHQIIASKKIDSQEFLSAV--------------KEQLLTEA---N 105

Human   386 SSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTE-----SLL 445
            ::|:   .|||...|......|.:..:.:|..||.:.::|.. ...:.|..|..:.|     |.|
Yeast   106 ANII---FEYVLDFWADGGAPLMNALRDLFSKLLNLLKITYP-MSTLKDVLFNWMNEILEVPSTL 166

Human   446 RLEWHIKGKYTCLGCLVECIGVEHIL--AIDKTIPSQILEVMGDQSLVPYASDLL---------E 499
            |::::          |::.:..:..|  .|:|. |..|     |.|.....||||         .
Yeast   167 RVQYY----------LIDALSSDFDLYYIIEKK-PHFI-----DNSFSLMNSDLLANSVGKCIVS 215

Human   500 TMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYM 564
            .:...::.|.|.   ..|::.:|.:.|.|..|           .|:.|....|.:     :|..|
Yeast   216 LLLNIYEKHFKK---NESFVQEWIQLWKSCAL-----------KYIHDKQYTKSI-----NLYIM 261

Human   565 VKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHG--------HLQSATDTWENLV 621
            :.:.      |.....:|.....|.|......|::.|:|.:..|        :..:..|:...|:
Yeast   262 IPLF------KNMPNSAFTLFLECMSNKDPSLLLSLLKIGQELGIEEEPFCDNKYTTVDSVNKLI 320

Human   622 SDARIKQGLIHQHCQVRIDTLGLLCESNRSTEIV------SMEEMQWIQFFITYNLNSQSPGVRQ 680
                       :..:.::....:|..|.:.::.:      ::::..:: ||:...|..     |.
Yeast   321 -----------EQDEYKLQVFEILTFSTKKSKPIRPFVFKTIKQYLYV-FFVDTELER-----RN 368

Human   681 QICSLLKKLFCRIQESSQVLYKLEQ-----SKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF 740
            ..||.:|....|.::.:   |.|.:     .|:::.|:.:..|   ...:::.:.|:..:||.:.
Yeast   369 YFCSSMKHFIFRTRDCA---YSLARDARKLKKAEKFPDEQREK---LAQVEEARAFLVWLCNFIK 427

Human   741 EALFPGSSYSTRFSALTILGSIAE--------------------VFHVPEGRIYTVYQLSHDIDV 785
            ..|.||:.|....::|.::..:.:                    .|.:|      :.|     ||
Yeast   428 YNLAPGTLYQANVTSLKLMHILIKSGVDKSTPQKFLDNQNKREYPFSIP------ILQ-----DV 481

Human   786 GRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASY 850
            ...:.|::...|.:.||:.|:.::|..:.       .:.:.:|||...|:
Yeast   482 TFLRLLIDLLVSNYADVRELSKEMLFIMI-------SADESRGLFLDTLD--------------- 524

Human   851 LLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVE-------------RNTLMVIKCLMENLE- 901
             .|.|.|  ...|.||.|       :.||..|.|.|             ..|:.::..:::||:
Yeast   525 -ANALKW--TATSLLSDY-------EKGDAGATVYEFIFTVMGSQRSFIDQTIDILAQMVQNLQN 579

Human   902 EEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPV 966
            :.:..||||:....||
Yeast   580 DSIGCAENSIGPHFAA------------------------------------------------- 595

Human   967 IQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNA--SVVNID 1029
                                 |.:|||:....:.:.  :.:||:.:..:..:|...|  :||..|
Yeast   596 ---------------------LSLILNKFNSEENHQ--DTSKIISKLINLVLKSWEATRNVVCHD 637

Human  1030 TSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGD 1094
            ::..|..::...|.|..|:::...:|::||.:.||..:.:..|           ||.:|:..|||
Yeast   638 SAHGILPEKYANCGVPDQVIISHAFRAIKEASYLLETILKKYP-----------LTRDQLDSIGD 691

Human  1095 YFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATR 1159
            .|...|...||.|||:....|   |.....|| .:....:.|:.|...::.:|    |.....||
Yeast   692 LFIVQLSTIRHSGAFQAVLPG---LKAFCIRC-QLEFPAILEELLSKSVKSLK----SKTQHITR 748

Human  1160 RSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAG---PTDDIQSTVPQVHALNILRALFRDT 1221
            ||.|:||.:..:|::|..||| .||:.|.:.|:.:|.   |....:..:|||:|:|.:.|:|.:.
Yeast   749 RSGGLPFLVTTVLSAEVTKGR-PLLQKTFENLLLVARLPIPPHQDEFDLPQVNAINCINAIFVEP 812

Human  1222 RLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNR-MTGREF 1285
            :|..:...:|::..:.|:|.|...:||:||.|.:||::|..||||         |..| ::.:.|
Yeast   813 KLSVHCTSFVSEALELALLNFDCDIWALRNCSIMLFTSLQNRIFG---------KVGRSVSAKLF 868

Human  1286 FSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPF 1350
            |:::..|...||..|.:..........:..:..|:||:|.||.||..     |:....:..|...
Yeast   869 FTKYSGLRQLLLNILNSSIAQYSGSERKSYQIESIFLVLNVLLRLRP-----TAGYTGLKEFNVS 928

Human  1351 IMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQ 1415
            :..|..:..:..|:||:|.|  .::.::....||.||. |.|..    :||.:||.||.:..|:.
Yeast   929 VYECLSNENWKIRDMASRVL--HMLSENFEEEIRKLLD-LASIA----KQNQLHGHLLALQQLVP 986

Human  1416 AYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSA------ 1474
            .|..   ||.   ..||....:..|..|.|   :|.|.:|:..|:.    ||||:..:.
Yeast   987 QYLS---GTR---DMELIQRILEKKRMLLL---ENKCFITKKAYLK----LTCCILETCDIPDSI 1038

Human  1475 -KDNQPVLESLGFWEEVRGIISGSELITGFPWAFKVPGLPQ------------YLQSLTRLAIAA 1526
             ||....|.:....|....::.||:.:.          |.|            ||..:..|.:.:
Yeast  1039 LKDYISTLRNTFIAENNEYVVDGSKQLY----------LAQILDMLLKYEDSIYLDDICLLGLYS 1093

Human  1527 VWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKF 1591
            .:..|..|..:..|....:.....|.|.|...|.|.                 ||.||
Yeast  1094 PFYEAQLSTLQYMNTNFHWETTRNSEFLEQLQLLLR-----------------VPDLL------- 1134

Human  1592 LLLAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRL 1656
                     |.....::||         |.:.::.:.||....|:.|.:....:.:.:.|::.:|
Yeast  1135 ---------PMAKALVVKI---------LSRKKNTLSLTTCTDLLKTNNSEDTKLAAVSSLSAKL 1181

Human  1657 ASKVISHHMQTCVENRELIAAELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPIL 1721
            :|:.. |.:...::.                 ...|....:.|||.:|.||: .|....|...:|
Yeast  1182 SSQTF-HQVWNLLQG-----------------FFADSCSKDFRLASLECLTA-YPESCKNSRILL 1227

Human  1722 ELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEFAFCQVDASIALALALAVLC 1786
            :|.:  .||        .::..:|:.|:..:     .:|..|:.::.:.: :.|:...:......
Yeast  1228 QLYN--FLW--------DDDSEIREKASFYL-----NKNFIQTADWEYNR-NTSVTALIFTKKFV 1276

Human  1787 DLLQQWDQLAPGLPILLGWLLGESDDLVACVES----MHQVEEDYLF----EKAEVNFWAETLIF 1843
            |:... .::...|.:.|...|.|. |:.|..||    :..:|:|..|    :||
Yeast  1277 DVFTS-SEVVEELCLQLFQYLNEY-DMFAAEESAKNCLFTIEKDNQFINELQKA----------- 1328

Human  1844 VKYLCKHLFCLLSKSGWRPPS---PEMLCHLQRMVSEQCHLLSQFFRELP----PAAEFVKTVEF 1901
                 .|:..::..:| |..|   .:.:.||:..:.|  |..::.|::.|    ..||.     |
Yeast  1329 -----MHILNMIKLTG-RDISKCYKDQIHHLKSALLE--HFNTEDFKDSPLGWCSNAEI-----F 1380

Human  1902 TRLRIQEE 1909
            :|:.:.:|
Yeast  1381 SRITLLKE 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_071348.3	COG5543	394..>1484	CDD:227830	248/1171 (21%)
		DUF2428	947..1248	CDD:463054	72/305 (24%)
TRM732	NP_013986.1	COG5543	1..1419	CDD:227830	341/1698 (20%)
		HEAT repeat	1154..1178	CDD:293787	5/23 (22%)
		HEAT repeat	1189..1218	CDD:293787	7/46 (15%)
		HEAT repeat	1224..1250	CDD:293787	6/40 (15%)