DRSC/TRiP Functional Genomics Resources

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Protein Alignment THADA and si:ch211-225b11.4

DIOPT Version :10

Sequence 1:NP_071348.3 Gene:THADA / 63892 HGNCID:19217 Length:1953 Species:Homo sapiens
Sequence 2:XP_005165257.1 Gene:si:ch211-225b11.4 / 561626 ZFINID:ZDB-GENE-060526-114 Length:1849 Species:Danio rerio


Alignment Length:1964 Identity:451/1964 - (22%)
Similarity:763/1964 - (38%) Gaps:432/1964 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    95 LKKVLASSLNSLPDFFLPEAMHRF-------------TS----RLQEELNTTDLYSYRKVTDNIS 142
            |:|:...:|:||.    |.|:||.             ||    :|.:.|....:.::..|.:.:.
Zfish    62 LQKIPKEALHSLQ----PPALHRLIQLILALQLEAVTTSSACRKLDQMLQVFAVINHSVVFEEVK 122

Human   143 SCMENFNLGRASVNNL--LKNVLHFLQKSLI--EILEENRKCAGNHIIQTQLMNDLLVGIRVSM- 202
            .|:.|. |.:..|.:|  |:.:..||:.|.|  |:|:.  :|       |.|:..:...|.|.| 
Zfish   123 QCLLNI-LHQKQVFSLKDLQIICMFLEDSTIGREVLKS--EC-------TTLLGKVAELIPVVMS 177

Human   203 ------------MLVQKVQDFQ------GNLWKTSDSPIWQNMC--GLLSIFTKVLSDDDLLQTV 247
                        |:...:|.||      ..|..:.||   .|:.  |:|....:::..:...:..
Zfish   178 DEASRNGPLCYQMVKGCLQVFQLLPGEVAQLVYSKDS---VNITARGILEFLMRIILGEVSSRDT 239

Human   248 QSTSGLAIILFIKTMFHPSEKIPHLISSVLLRSVDCTSVPEWFMS------SCRSLCCGDISQSA 306
            :..:|.|:.:.:.|...     .....|.....:..|....|.::      :|.|.|...:.:.|
Zfish   240 RLLAGTAVAMLLSTATD-----SQCAGSAAWSLLQITKTEPWRLTVGELQVNCSSRCQDGVDRLA 299

Human   307 VLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLE--MFLSRILASW----TN 365
            |   |:|.|.... .:..:.|..........|.|....|.:.|..|:  .|:.::...|    ..
Zfish   300 V---CRGLLTCCK-NDVLVSRHSNQKTCFLLHGLLPFISALCEEKLDCHYFVFQVFTIWLKRLKE 360

Human   366 SAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVE--G 428
            ...:|.|.:...|      :|.:..||.:.::.:.|.|||.:....:..|...::::....:  |
Zfish   361 CLSEVWEVTGAPL------DSDLQHRLTQIIWRNSESPLDGVAEVARSAFCLFMEIYEKDCQHFG 419

Human   429 ADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPY 493
            .:   ...:|||.:.:..|.|..|.||..|..::...|...:|.:...:|..:|:.:....|.|.
Zfish   420 TE---KSLYVELLKRISELPWESKAKYLPLTAVLPYTGTNKVLELYPALPYHLLKCLSTNHLSPC 481

Human   494 ASDLLETMFRNHKSHL----------KSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDY 548
            ||::.:::.:..|..|          ..|...:.|..||.                         
Zfish   482 ASEVYKSLLQEQKRELIIIASKEAPPTDQYLANQWAHQWQ------------------------- 521

Human   549 YLPKLLSYSPESLQYMVKILQTSIDAK--TGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQ 611
              |.:|    |:|...:.:||.:..:.  ....::||        ||...|::.|. ..|.|||.
Zfish   522 --PVIL----EALTSEITLLQNNASSHLLPTTLRTFP--------GAFNTLLSALN-PSAPGHLH 571

Human   612 SATDTWENLVSDARIKQGL---------IHQ--H---C----QVRIDTLGLLCESNRSTEIVSME 658
            :    |..::|..|...|.         :||  |   |    .||:..|.|||.|.::.|..|..
Zfish   572 A----WACVMSAQRATSGRSLWGAESSHVHQTLHLALCSLDDSVRLAALNLLCCSPKTNEAPSQL 632

Human   659 EMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSV 723
            |...::.||..|||.:|...||.:.:.|:|...||::|...:.|...|| |...|.|:.:     
Zfish   633 EYSALRDFIPLNLNCESSPFRQHLQAALRKFLVRIRDSCMAIIKGRNSK-KGLTEEEVAE----- 691

Human   724 SLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVF----------HVPEGRIYTVYQ 778
             ::|...|:..:.......|.|.|||..:.:.|.:|.::.|..          ..|...:.|:..
Zfish   692 -IEQGVEFVEWLFQLSLVYLSPDSSYQRKKTVLLLLCAVLETCTDTWSPDRKKGQPPANMSTLIN 755

Human   779 LSHD------IDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELS 837
            .:.|      ....:...|:.|...:..:::.|:.:||.:                .|.::|   
Zfish   756 WAKDRGKWDFFSKSKLLVLIGCLEDSTNEIRELSAELLFR----------------FFPSSL--- 801

Human   838 TSTKPYD--CV---TASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLM 897
                |.|  ||   .|..||.....|:|...:|...|..|.|    |......|:.::.:|..|:
Zfish   802 ----PDDVTCVLFSRADQLLQSPRVQEAQMGALMVKLLLQKA----DGVFNQGEKQSVKLITFLL 858

Human   898 ENLEEEVSQAENSLLQAAAAFPMYGRVHCITGALQK--LSLNSLQLVSEWRPVVEKLLLMSYRLS 960
            ..||:....|.:.:|.||...|    ||.|..|||:  |.:..:.|.|....:..:|:|:..:|:
Zfish   859 SKLEQHYLTARSDMLLAARTTP----VHGIVSALQRGLLEVPGVLLESITHSIAGELVLLLEKLT 919

Human   961 TVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSF-DMKDLNAS 1024
            .|:..|:..:       .||:.:          ::.|                 || ||.:..:|
Zfish   920 LVLLGVLYGN-------QDTEEK----------DVPP-----------------SFCDMGNAISS 950

Human  1025 VV---NID-TSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLT 1085
            ::   .:| ...:..|:|.........:||.|||.|:||:.:.||.|.:.:......|..   |:
Zfish   951 LIGQGGVDGVGLDEDGEENVLLSEEHSLVLTCCWVSLKEIGIFLGSLVERILSLHCEELK---LS 1012

Human  1086 VEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSD 1150
            ||:::.....||..:|:.||.||.|....||.|....|....:..::::|...|...|..::  .
Zfish  1013 VEELRTASKVFKDIILKCRHWGAVEGCCVGFTKFCRALLSSSDPDIRQIPSLMLQQGLSVLQ--S 1075

Human  1151 PSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAG---PTD-DIQSTVPQVHAL 1211
            ||| ...|||:||:|..|..:||:|.......||..|:..|:..|.   |:| |....:|||.|:
Zfish  1076 PSS-TSVTRRAAGLPMLILGVLAAEDSSKSRPLLAHTINTLLDTAKALLPSDWDQTLDLPQVCAV 1139

Human  1212 NILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSK 1276
            :.|:||.:.:.||..::.:....|..::...:|..||:||::..|:|:|.||:.|.::| .|.|.
Zfish  1140 HTLQALVKGSSLGVAVLQFTPAMAVLSLTLLSSACWAMRNAALQLYSSLCTRMLGQQKA-GEGSS 1203

Human  1277 TNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPN--RHPSMFLLLLVLERLYASPMDGTS 1339
            .:.|:...||..:|.|.|||...|||.||    |:.:..  .||:::.:|.:|.:|.......|.
Zfish  1204 NSGMSAASFFHLYPALQPFLQGALETAAN----DLHDATLLLHPALYPVLTLLSKLQPGAEKQTR 1264

Human  1340 SALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIH 1404
               ::..|:|.::....||||..|.|:::|||..:.......|:..|:..||...|.....|.:|
Zfish  1265 ---ALSEFLPPLLLLSASPVYGVRVMSSKALVAMIPTSEYMATVLQLVKDLPESPDVVSCHNRLH 1326

Human  1405 GTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLT-- 1467
            |.|||...:|.....|...:.|     |:::....:::|||...:..|.:.|..|:||:.|:.  
Zfish  1327 GKLLQTRAILTRALRSSVSSLS-----LSEVVDVFESRLWLGSSKQRCPLVRQSYVDIVRLIRGH 1386

Human  1468 CCLNRSAKDNQPVLESLGFWEEVRGIISGS------ELITGFP-WAFKVPGLPQYLQSLTRLAIA 1525
            |.....::.:..:|..:....::..|.:.|      ..:.|.| ||.      |..:||.. ..|
Zfish  1387 CSAGFLSQLSSQLLHEIQRTPDILEIGAASFHQSTVNFLCGDPEWAC------QAWRSLAN-GNA 1444

Human  1526 AVWAAAAKS-----------------GERETNVPIS------------FSQLLESAFPEVRSLTL 1561
            .|..:..||                 ||.:.|:..:            .:.|:|...||..||.|
Zfish  1445 VVQLSLVKSVTDGHGWRGTDLQQVIEGELKANLKAALMSQSVDYRAAYLTALVEVLTPEEESLGL 1509

Human  1562 EALL-EKFLAAASGLGE------------KGVPPL----LCNMGEKFLLLAMKE--NHPECFCKI 1607
            ..|. .:|  ..:||.|            :|.|.|    ||.:.   :||:...  :..:.:||:
Zfish  1510 SRLCPSEF--EQTGLQECVELLLNDLETDRGGPALISTALCAVS---VLLSQSADVSFLQRWCKL 1569

Human  1608 LKILHCMDPGEWLPQTEHCVH-----------------LTPKEF---LIWT-MDIASNERSEIQS 1651
            |:...|.|..|.|...  |..                 |.||..   ||.| :.:..:|.|::::
Zfish  1570 LEKHRCPDAPEALRSA--CAQSLCLCGVSVVTRSLTSSLIPKHLNTSLISTGLFLLQDESSDVRA 1632

Human  1652 VALRLASKVI----------SHHMQTCVENRELIAAELKQWVQ----LVILSCEDHLPTESRLAV 1702
            .|...||.:.          ..|||.....|.|:...|:::..    |..|.|  |||:.....:
Zfish  1633 KAAIFASLLCCSRQPEAPQRCFHMQVNQALRSLLDLLLEEFWDTSGALEALLC--HLPSCDLNII 1695

Human  1703 VEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLL--------QS-------EEQAVRDAAT--E 1750
            ::....|....|..|.......:...:.:|:|..|        ||       |..|...|||  |
Zfish  1696 LKQAKDTQCRSLYEPDEANVFAEPSVISECLLPYLLRLVKHYPQSSSLAENLERWARNSAATVKE 1760

Human  1751 TVTTAMS-QENTCQSTEFAFCQVDASIALALA-----LAVLCDLLQQWDQLAPGL-PILLGWLLG 1808
            .:.|.|. |.:...:.::....::.....|||     ..||..:|...|.:.|.| |:.|     
Zfish  1761 NLATCMQLQLSDVLNPDWLSLLIEPHFHGALAGLFTRAIVLLQMLNDCDSIRPLLDPLSL----- 1820

Human  1809 ESDDLVACVESMHQ 1822
             |.||    :.:|:
Zfish  1821 -SSDL----QDIHK 1829

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
THADANP_071348.3 COG5543 394..>1484 CDD:227830 283/1157 (24%)
DUF2428 947..1248 CDD:463054 78/309 (25%)
si:ch211-225b11.4XP_005165257.1 COG5543 351..>1337 CDD:227830 275/1124 (24%)
DUF2428 929..1176 CDD:463054 73/286 (26%)

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