DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment THADA and thada

DIOPT Version :9

Sequence 1:	NP_001077422.1	Gene:	THADA / 63892	HGNCID:	19217	Length:	1953	Species:	Homo sapiens
Sequence 2:	NP_001013501.1	Gene:	thada / 541356	ZFINID:	ZDB-GENE-050320-49	Length:	364	Species:	Danio rerio

Alignment Length:	363	Identity:	118/363 - (32%)
Similarity:	196/363 - (53%)	Gaps:	10/363 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     3 VKKKKEMQVAALTICHQDLETLKSFADVEG----KNLASLLLHCVQLTDGVSQIHYIKQIVPLLE 63
            |.|||..:|.|..:....|::|.....:||    ..||.||...:...|.|.||..|.:...:||
Zfish     2 VVKKKAPKVEAFVLDDVKLKSLTDSLSMEGDCKSTELAQLLKDSLSSFDPVEQIQLISKAGCMLE 66

Human    64 --KADKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEEL 126
              |.|:: ...|.:::||..|:.:|::|..|||||:.::|:|.|.||:...:.:...:..|....
Zfish    67 QLKEDES-PSSPLLEACLHTLSFLYITLPAKNPLKRAVSSALGSGPDWLQEQMVRCLSEGLSAAF 130

Human   127 NTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKCAGNHIIQTQLM 191
            ::.....:..:||:|:||:..|.:|...|::||..||.|.||:|...:|:||...|.|:.|.|||
Zfish   131 SSASTDHFSNLTDSITSCLSGFLIGEKCVHHLLTEVLQFFQKALNYYVEQNRILVGCHVAQAQLM 195

Human   192 NDLLVGIRVSMMLVQKVQD--FQGNLWKTSD-SPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGL 253
            ...|..::.||::||:.|:  ....|..:|| |.::|.:.|||:.:|.||:|::.:|.||||:|:
Zfish   196 QYSLAAVKASMLVVQQSQEPISAAVLSASSDQSDLYQALSGLLNCYTCVLTDEEFVQAVQSTAGM 260

Human   254 AIILFIKTMFHPSEKIPHLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAML 318
            |.:|.|:::....:.:..:::.:|..|||..|.|:|...||..|.......:..|:|..|.||||
Zfish   261 AAVLLIRSLLGNGDNLHFIVAGLLQCSVDAGSTPQWLRKSCAGLYESSRPAAVALYLSHGALAML 325

Human   319 DWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFL 356
            .|:..::......|||....||.:|.::.:..|:...|
Zfish   326 SWKGKTLSPQAVKLLLLIPDVLLSLHTRYRMITITFTL 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
THADA	NP_001077422.1	DUF2428	952..1247	CDD:287339
thada	NP_001013501.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342959
Domainoid	1	1.000	666	1.000	Domainoid score	I1304
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1384	1.000	Inparanoid score	I1162
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG40512
OrthoDB	1	1.010	-	-		D18527at33208
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	1	1.000	-	-		oto51001
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	LDO	PTHR14387
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2730
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.410