DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment THADA and THADA

DIOPT Version :10

Sequence 1:NP_071348.3 Gene:THADA / 63892 HGNCID:19217 Length:1953 Species:Homo sapiens
Sequence 2:NP_608361.3 Gene:THADA / 33001 FlyBaseID:FBgn0031077 Length:1746 Species:Drosophila melanogaster


Alignment Length:2041 Identity:451/2041 - (22%)
Similarity:769/2041 - (37%) Gaps:542/2041 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     9 MQVAALTICHQDLETLKSFADVEGKNLA----------SLLLHCVQLTDGVSQIHYIKQIVPLLE 63
            ::||||.:|...    |.||::....:.          ..:|..........|:..:|.:. ..|
  Fly     6 LRVAALKVCAHP----KRFAELRDALVPLPNTWIAAPHDFVLQFAAAKSSAEQVQVVKDVF-YGE 65

Human    64 KADKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASSLNSLPDFFLPEAM-------HRFTSR 121
            :|..:           :.:|.....|.|.:|||..:.:.|..|   |...|:       ||..|:
  Fly    66 QAQDH-----------EDVAHFLADLLLASPLKHAVRNQLTKL---FSDNALAKQNASPHRRHSK 116

Human   122 ------LQEELN--------TTDLYSYRKVTD---NISSCMENFNLGRASVNNLLKNVLHF---- 165
                  ||:.|.        .|...|:.:..|   :.::|::||..||.::.   |.|..|    
  Fly   117 EHLLEALQQSLGEMANSLAVITPPVSHERTNDVFVSANACLQNFPFGREALG---KQVHRFAPLL 178

Human   166 ---LQKSLIEILEENRKCAGNHIIQTQLMNDLLVGIRVSM-MLVQKVQDFQGNLWKTSDS--PIW 224
               |::...:|      |.....:.....|:|.:.::.:: .||..:.::...|....|.  |..
  Fly   179 TTALERYWADI------CDPTLELSPTRRNELYLYVQNALRFLVSLLAEWSDKLRLFEDQRFPGT 237

Human   225 QNMCGLLSIFTKVLSDDDLLQTVQSTSGLAI----------ILFIKTMFHP--SEKIPHLISSVL 277
            .|     ::..||....|....|:|.:.|.|          ..:::....|  .:.:|..::::|
  Fly   238 SN-----AVAQKVARYYDTPWDVRSIAALLIGHLARFSGTFKAYVEDCSRPKAEQDVPIQMAALL 297

Human   278 -LRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLF 341
             ||.||.|.                 :.:..|.:.:..:|:.:.::     :...||:..:..||
  Fly   298 VLRPVDYTE-----------------NATLALAILKRIVAVSELKS-----TVTNLLVFLSKHLF 340

Human   342 TLSSQIKE------PTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHW 400
            ..|..:.|      ...::...||||.....|:|.:.|.:                         
  Fly   341 IYSKSLGEMHAHLPDDQKLLYQRILAQLQVFALQNISSDT------------------------- 380

Human   401 EHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECI 465
                |::||.:..:...:||  .....|.:        ||.:.:.| ::..:..|....|     
  Fly   381 ----DSVRHMSSALLHQVLQ--HAQAAGQE--------ELFQVVYR-QFEDRAAYLNASC----- 425

Human   466 GVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNH----------------KSHLKSQTA 514
                 :|::     |::.|.|....:.....|...:|..|                .:|.....|
  Fly   426 -----MALE-----QLVAVAGVSKSIENCPSLFGVIFPRHLGCEDCVDALFKAMMVSAHKTEPFA 480

Human   515 ESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQE 579
            |      |...|...||..:...  :::..||:..:.:.:...|..|..::.           .:
  Fly   481 E------WQSRWFGLLLAAIRVP--EKRRQVIEELIAQAVQLEPTRLAQVLL-----------PD 526

Human   580 QSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDAR--IKQGLIHQHCQVRIDTL 642
            ...|.  ||.....||......|              .:||:...:  ::|.||......|:..|
  Fly   527 DRLPL--SCKLAAILGVRQLSAR--------------RQNLLRGMKEEVEQALIGLDDHTRLLAL 575

Human   643 GLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSK 707
            ..|.|:.|.:|:::.::|..|:.::.:|.|:.|..:||....||:|...|:.      :.|.:.:
  Fly   576 RFLVETPRPSELLNADQMGAIELYVRHNANNPSAHLRQLGYGLLQKALKRVH------FGLVEYR 634

Human   708 SKREPENELTKQHPSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGR 772
            ..|.|.:           |:...|:..:..:|.:.|||.::|..|:.:|.:|....|:..:..  
  Fly   635 KSRTPAS-----------QEVLQFLIRLIRTLAQNLFPTANYGRRWLSLRLLRDCLELSEMVG-- 686

Human   773 IYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELS 837
             .|..:|..::..   :.||.|...::|..|:||..||.:....::...|.         .:||.
  Fly   687 -ITFSELGIELPT---EALMACLGDSYEHNKVLAAQLLERFQSHSLFKPDE---------MIELL 738

Human   838 TSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACD----NGDRP-----AAVVERNTLMVI 893
            .|.:|.|..|.::.|                   ||.|.    ..:.|     ..:.|..|...:
  Fly   739 LSLRPSDSATGAFQL-------------------QVYCKASRVQSEMPTPTHGGTIHEPLTFRAL 784

Human   894 KCLMENLEEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYR 958
            :..:::|.|.:..|:..|.:||...|:||.:......||:|.|..|....:||..:::|:.|...
  Fly   785 QWCLQHLREGLRLAQLDLGEAAKLNPLYGLLFASRHLLQQLKLKELAKEPQWRQYIDELVTMCLA 849

Human   959 LSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNA 1023
            :|:||.||:.|:||||.:|...|.|:...|..:|:.                             
  Fly   850 VSSVVLPVVSSASPEGHLPETCDQETDQPLTNVLDR----------------------------- 885

Human  1024 SVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPM------QPVPESSDG 1082
                     ::..:|:.....|.||:|:|.|||.|||.|:||.|.|..|:      :...:..|.
  Fly   886 ---------QLSREELLQVRTTPQMILLCAWRSSKEVCLILGELVQRAPLEEEEDEEQQQQQGDF 941

Human  1083 LLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEI- 1146
            ||:..|::.||::|.|.|.:::||||||.||.||..|........:|.|.:||.||:...:..: 
  Fly   942 LLSRAQLEAIGEHFLQLLAETKHRGAFEQAYVGFTMLCRRFWHSESVRLNQLPGQWVDEAMAMVS 1006

Human  1147 ---KCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLA-GPTDDIQSTVPQ 1207
               :.:...::|||||||||:||.:|||:.:|.|.|....|...|..|:.:. ..|........:
  Fly  1007 GQEEWAGKGARLCATRRSAGMPFMLQALVGTELKLGTHATLYRCMNRLLEVCERRTGGAAGITAR 1071

Human  1208 VHALNILRALFRDTRLGENIIPYVADGAKAAILG-FTSPVWAVRNSSTLLFSALITRIFGVKRAK 1271
            .|||||:|||||.:.|.|.:..::|.|.:.|:.| ..:..||.|||:|||.:|||.|:|||:||:
  Fly  1072 SHALNIMRALFRSSELAELVTEFMARGIQCALDGLLLAEEWAERNSATLLLAALIVRVFGVERAR 1136

Human  1272 DEHSK---TNRMTGREFFSRFPELYPFLLKQLETVANTVD-----SDMGEPNRHPSMFL--LLLV 1326
            .|..:   .||||||.||:|:|:|:.:....|:..:..:|     |:.....|..::.|  :||:
  Fly  1137 LETGELHVRNRMTGRIFFTRYPQLFDYFHAALQRESEQMDAGGGGSENASGKRRQAVQLEAMLLM 1201

Human  1327 LERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLP 1391
            |.|||.|.::|..|.|::..||||::|..||....:|||||..:..||..:.....||.::..|.
  Fly  1202 LSRLYPSSLEGAESTLNLSEFVPFLIRICHSHDLMTREMAALVVANFVTQEQALAEIRRIVVELK 1266

Human  1392 S---------CTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAK 1447
            :         ..:.....|.:||.||.:.||        |......:..||.:.:.|.|:|....
  Fly  1267 ALQLRLKNTEAANTKLNTNVLHGQLLLLLHL--------HRLVRWTRPSLTRMQLHTLAELAAPL 1323

Human  1448 RQNPCLVTRAV-----------------------YIDILFLLTCCLNRSAKDNQPVLESLG---- 1485
            .|:......|:                       .|.:::||      :.|:.|...:.||    
  Fly  1324 LQHDACAFSALVAVMVAAMEDAVEPGLLDFQLLEQIGVVYLL------NHKEVQSRCQQLGISNR 1382

Human  1486 FWE-------EVRGIISGSELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPI 1543
            |::       .:|||..|..|              ..::.|..    .:||.      .|..|.:
  Fly  1383 FYQIFGLHLHRLRGISQGIVL--------------HIVEDLAE----TIWAL------DELKVEL 1423

Human  1544 SFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENH-------- 1600
            ....||:.:..|..||..|..:|.|..:.             ::...|..|:.::..        
  Fly  1424 WLYILLQRSLSEQNSLVSEQDIEHFEFSR-------------DIRRYFETLSREQREEVGQELYE 1475

Human  1601 -PECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHH 1664
             |.....:|.::|.:...:     ..|          |::.:|.  |.......||.....::..
  Fly  1476 SPAVRSSVLHMMHMIKSSK-----NSC----------WSLQLAG--RLAALQTLLRDPGLELNQL 1523

Human  1665 MQTCVEN-------------RELIA----AELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPL 1712
            :|.|.|.             |.||.    .|.|.|:.:        |....||     :....|:
  Fly  1524 VQRCSEEHSTHQEAGLLLGLRRLIGESKMLERKHWLPM--------LNYAQRL-----VHPGQPV 1575

Human  1713 FLTNPHPILELQDTLA----------------------LWKCVLTLLQSEEQAVRDAATETVTTA 1755
            :|.  |...||.|:||                      ....||.||..:.:.||..|.:.|..|
  Fly  1576 YLR--HQAAELCDSLARNHLRDQLVAGTTDVDIGLVGRFSGLVLLLLHDDAEWVRHRAVQLVCGA 1638

Human  1756 --MSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLV---- 1814
              .::....|..|.:          |:|..:|...|     :.|.|..::|.|..:..::|    
  Fly  1639 GLRTRSGAGQEQEQS----------AMAPLILPSAL-----IPPFLDTMIGKLTFDDFNMVQRLV 1688

Human  1815 -ACVESMHQVEEDYLFEKAEVNFWAE 1839
             ...|.....:...||:|.|.|.:.|
  Fly  1689 DIIAEPFTTADAMELFDKQENNHYCE 1714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
THADANP_071348.3 COG5543 394..>1484 CDD:227830 291/1170 (25%)
DUF2428 947..1248 CDD:463054 98/312 (31%)
THADANP_608361.3 DUF2428 863..1113 CDD:463054 74/264 (28%)

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