DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THADA and SPCC1494.07

DIOPT Version :9

Sequence 1:	NP_001077422.1	Gene:	THADA / 63892	HGNCID:	19217	Length:	1953	Species:	Homo sapiens
Sequence 2:	NP_588532.1	Gene:	SPCC1494.07 / 2539238	PomBaseID:	SPCC1494.07	Length:	1502	Species:	Schizosaccharomyces pombe

Alignment Length:	1706	Identity:	364/1706 - (21%)
Similarity:	651/1706 - (38%)	Gaps:	412/1706 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   273 ISSVLLRSVDCTSVP---------------------EWFMSSCRSLCCGDISQSAVLFLCQGTLA 316
            :|.:...|:|..|:|                     :|::.:             .||....:..
pombe     3 LSVIKAASLDLESLPSQPTVSSFQQLRETFIQSKSEDWYLKN-------------GLFFRYYSFL 54

Human   317 MLDWQNGSMGRSGEALLLDTAHV----LFTLSSQIKEPTLEMFLSRILASWTN-SAIQVLESSSP 376
            ....:|.::....:...|||..|    :|....|..|.:..::.:..|..||| .::...:.|.|
pombe    55 KSSLENATLDGPSQVACLDTISVWLRRIFNACKQDPEISKYVWDTMELKFWTNLFSLPANKISIP 119

Human   377 SLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELT 441
            .||                          .::...|.:|...||::.|.....| :.:.|.::..
pombe   120 GLT--------------------------GVQVAVKDVFSKSLQLYLLVCPSED-IKNDFLLDSL 157

Human   442 ESLLRLEWHIKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHK 506
            :..|..:.|.|...|.:..||:..|.|.:.|.......|.|:::.|.|.....|..:.|:.....
pombe   158 KHALHWDRHAKVVCTAIQLLVKVTGAEAVFAFQPDFFEQSLKLLKDYSYAQAISSTILTVLTLRF 222

Human   507 SHLKSQTAESSWID-QWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVKILQT 570
            ..|..:|.:...:: :|...|...:|:.....:...::.:..:.:|.||..||   ...||.|
pombe   223 KSLSEETEDREEVETKWMNIWCPIILYEFYGNDRQVQAGMSSFLIPSLLGVSP---GITVKFL-- 282

Human   571 SIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSD-ARIKQGLIHQH 634
                  .:.|::|:: |.::|.|  |.:..|:||:....:::.     :||.: |.:|....|..
pombe   283 ------SRLQNYPNV-SKDARDA--ACLYALKIAKDSKIIKNL-----DLVKEHAFVKTLFKHPD 333

Human   635 CQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQV 699
            .::::....|:......:..:|.|:...::..|.::.|...|..||.:...::..|.|::.|...
pombe   334 IKIQLACFRLIALCPNVSSPLSFEDFDCLESNIEFSFNVLDPDSRQILLKSMQDFFIRLRASCHS 398

Human   700 LYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAE 764
            :.:..:|:..       .|...|..|.:...|::|..:...:.|:|..:|.....:|:.|.::..
pombe   399 IARTMRSRHS-------DKVALSGLLDRAMQFLTSFISVCKKHLYPTCNYQQVLVSLSFLDTLIS 456

Human   765 VFHVPEGRIYTVYQLSHD-------IDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQD 822
            ..........::.:..||       ||....:.:::.....::|::.|...:|:.. |:...|..
pombe   457 FGLDDNVESSSIREAQHDFPFSMVIIDRDLSRLMIDRLKDPYDDIRNLCLKILLSY-KSLPGFIS 520

Human   823 SGKLQGLFQAALELSTSTKPYDC---VTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAV 884
            ......||...|||..:.:.::|   ....||.|..: :.::|.|:.|
pombe   521 DSDAYFLFNHGLELLNAVRSHECDGGAKTIYLCNHFM-EKSVPGSVLA----------------- 567

Human   885 VERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSE-WRPV 948
               ||.:::..|..|:|    .|:.|||:||...|:.|.:..:|...|.||...::..:| |:.:
pombe   568 ---NTKVILNRLKSNIE----HAKTSLLEAAVNCPLQGYLIQLTYIFQSLSPTIVKNDNESWKNI 625

Human   949 VEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEH 1013
            |.:|:..|..:..::..|:...||||.:|   |.|....:
pombe   626 VMELIKASETIWGLIKDVLCDDSPEGNLP---DGEGEGGI------------------------- 662

Human  1014 DSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGML---CQLLPMQP 1075
                       |.|::             |..||::|...|||:||.:.||.:|   |..|
pombe   663 -----------VSNLE-------------DTPAQLILSYSWRSLKETSSLLTVLLTKCLSL---- 699

Human  1076 VPESSDGLLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLW 1140
                .|...|...:...|:.....|.:.||||||...|..|::....|..|....:.:||:.||.
pombe   700 ----FDEEFTPFTLNYYGELMMTWLWEIRHRGAFTSVYPCFIEYCSFLFECNKHEISELPDPWLH 760

Human  1141 SVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLA-GPTDDI--- 1201
            ..|..|:  :.||.:  ||||.|||..|.|:|.:...| |..|::.|:..|||:| .|.:..
pombe   761 KNLSVIQ--EKSSFI--TRRSGGIPLSITAILVAGKDK-REQLIEQTVISLISIAKQPVEQKNIA 820

Human  1202 -QSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIF 1265
             |..:|||||:|.|:.:|.:.||....:.|:......:|.||:..:|.:||.|.:||:|||.|.|
pombe   821 GQFDLPQVHAMNTLKTIFTEHRLSSVSVEYLEPAIALSIEGFSHELWPIRNCSVMLFTALINRAF 885

Human  1266 GVKRAKDEHSKTNR--MTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPS--MFLLLLV 1326
            |.|:.||..:..|.  ::.:.|||:||.|:.:||::||....::.|     |..||  ::.:|.:
pombe   886 GSKKPKDAVNLGNNKGLSTKMFFSKFPTLHDYLLRELEVSVASLSS-----NDQPSTGLYPILNM 945

Human  1327 LERL-YASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTL 1390
            ..|| ||.|....:....:..|.|.|.:|..|.:...||:|:.:|...:....:...|.:.|..:
pombe   946 FSRLQYAQPYGNENEWTGLSQFEPLIFKCTASRICKVREIASLSLTCLLDCSKMTTFIVSQLKGV 1010

Human  1391 PSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVT 1455
            ..     .:||.|||.||.:..:|.                      |..:||.|.:.|....|.
pombe  1011 AG-----LQQNEIHGKLLTIRAVLS----------------------CFFSKLTLQQVQEFYEVV 1048

Human  1456 RAVYIDI---------------LFL--LTCCLNRSAKDNQPVLESL-----GFWEEVRGIISGSE 1498
            ...:|:.               |||  |......:...|...|:.|     .:.:  |.::....
pombe  1049 PLAFINCFLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCK--RMLLDRKA 1111

Human  1499 LITGFPWAFKVPGLPQYLQS-----LTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRS 1558
            .:|.   .|...|||.:.|.     |..|...:|:..|...|       ...|:||...|.||:.
pombe  1112 NVTN---VFNTIGLPIHQQMAATIFLENLKEFSVYCDAHSIG-------FLVSKLLHYEFYEVQL 1166

Human  1559 LTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQT 1623
            .||.::::                   :..:|.::     |:||    ||:.|
pombe  1167 TTLRSIVD-------------------SPRKKIIV-----NNPE----ILQAL------------ 1191

Human  1624 EHCVHLTPKEFLIWTMDIASNERSEIQSVALRLAS--------KVISHHMQTCVENRELIAAE-- 1678
               :.|||:           |:.|:::::||.|.|        :::.......|.|  :::.|
pombe  1192 ---IKLTPR-----------NQWSQVRALALSLLSDSLNSTSYRLLGISCSDMVSN--ILSNECL 1240

Human  1679 -LKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQ 1742
             :|:...:::.||...|.||:                     .||.:.|.|.|..:|....:|.|
pombe  1241 PIKESFIVLLGSCIKQLKTEN---------------------FLEYKVTFAKWVEILLSYSNEYQ 1284

Human  1743 --AVRDAATETVT--TAMSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLAPGLPILL 1803
              :.|.||.:::.  ...:.|:|.::..|.|..                           |.:||
pombe  1285 PFSSRKAALDSIIHFDLFNAESTAEAFSFEFYI---------------------------LYLLL 1322

Human  1804 GWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSKSGWRPPSPEML 1868
            |..|.:.|:.:..:.:.|..:......:.....|            :|:.|.:|:.:........
pombe  1323 GDFLNDDDEEIRSLAANHAYQVLGTSAQCVTEIW------------NLWKLRTKATFGGQHDFQH 1375

Human  1869 CHLQRMVSEQ-CHLLS 1883
            |..:|::.|. |.|.|
pombe  1376 CINKRLILEDGCELAS 1391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_001077422.1	DUF2428	952..1247	CDD:287339	82/302 (27%)
SPCC1494.07	NP_588532.1	COG5543	2..1502	CDD:227830	364/1706 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2318
eggNOG	1	0.900	-	-		E1_COG5543
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I1015
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	1	1.000	-	-		oto146503
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	O	PTHR14387
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820