DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THADA and Thada

DIOPT Version :9

Sequence 1:	NP_001077422.1	Gene:	THADA / 63892	HGNCID:	19217	Length:	1953	Species:	Homo sapiens
Sequence 2:	NP_898842.2	Gene:	Thada / 240174	MGIID:	3039623	Length:	1938	Species:	Mus musculus

Alignment Length:	1955	Identity:	1532/1955 - (78%)
Similarity:	1704/1955 - (87%)	Gaps:	19/1955 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLLEKA 65
            ||||||:||||||||:||||:|||:||||:|||||||||||||||||||||||.||||||||||.
Mouse     1 MGVKKKREMQVAALTVCHQDMETLRSFADMEGKNLASLLLHCVQLTDGVSQIHSIKQIVPLLEKV 65

Human    66 DKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEELNTTD 130
            ||||:|||.||||||||||||.||:||||||||||||||.||:.||.:|.|.||..|||||:|.|
Mouse    66 DKNGVCDPAIQSCLDILAGIYFSLTLKNPLKKVLASSLNGLPEVFLTQATHSFTFHLQEELDTAD 130

Human   131 LYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKCAGNHIIQTQLMNDLL 195
            |||||||.|||||||||||||||||.||||:||||||||||||||||||.|||.|:|||||:|||
Mouse   131 LYSYRKVMDNISSCMENFNLGRASVVNLLKDVLHFLQKSLIEILEENRKFAGNRIVQTQLMSDLL 195

Human   196 VGIRVSMMLVQKVQDFQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIK 260
            ||:||:|.||||||..||:||..|.|||||:||||||||||.|:||||||||:||||||:|||||
Mouse   196 VGVRVAMTLVQKVQGPQGSLWNDSSSPIWQSMCGLLSIFTKFLNDDDLLQTVESTSGLAVILFIK 260

Human   261 TMFHPSEKIPHLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSM 325
            |||.||||:|.||||:||||.:|||:|||.|:|||||||.|:..|.:||||||||||||||:|||
Mouse   261 TMFRPSEKLPGLISSLLLRSAECTSIPEWLMNSCRSLCCTDVPASTLLFLCQGTLAMLDWQDGSM 325

Human   326 GRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGNSSIVG 390
            |.||||||||..||||||||||||.||:|||||||||||:||||:|||.|..|...|||:|.:..
Mouse   326 GPSGEALLLDIVHVLFTLSSQIKESTLDMFLSRILASWTSSAIQILESGSSGLKGHLNGDSCVPR 390

Human   391 RLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKY 455
            ||||||||||||||||||||||:||:|||||||||:||||...|||.:|||:|||:|||||||||
Mouse   391 RLLEYVYTHWEHPLDALRHQTKVMFRNLLQMHRLTMEGADLATDPFCLELTKSLLQLEWHIKGKY 455

Human   456 TCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWID 520
            .|||||||.:|:|||||||||||||||||||||||||||||||||||:||||||||||..::|:|
Mouse   456 ACLGCLVETLGIEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFKNHKSHLKSQTVTNTWMD 520

Human   521 QWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQSFPSL 585
            :||||||.|:|.:||.|||||:|||||||||::|:||||||.|||.|||.|.|..|
Mouse   521 KWHETWVFPVLSVLCGGNLDQRSYVIDYYLPRILNYSPESLHYMVHILQASTDTGT--------- 576

Human   586 GSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR 650
            ||||.||||||||||||.|||||||||||..|||||..||:||||||||||||||||||||||||
Mouse   577 GSCNHRGALGALMACLRTARAHGHLQSATQAWENLVCSARVKQGLIHQHCQVRIDTLGLLCESNR 641

Human   651 STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENE 715
            |||:||.|||||:||||||||||||||||||||||||||||||||||||||||||.||..:.||.
Mouse   642 STEVVSTEEMQWVQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQRKSTPDSENG 706

Human   716 LTKQHPSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLS 780
            ..::.|||:||||||||||:||.|||||||||||||||||||||||:||||..|||.|.||||||
Mouse   707 SIREQPSVTLQQYKNFMSSVCNILFEALFPGSSYSTRFSALTILGSVAEVFPDPEGNIQTVYQLS 771

Human   781 HDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSK-TAVHFQDSGKLQGLFQAALELSTSTKPYD 844
            ||||.||:|.||||||||||:||.||||||||||. ||..||||.|||.||||||||||||||||
Mouse   772 HDIDAGRYQILMECFTSTFEEVKTLAFDLLMKLSSVTAGQFQDSEKLQDLFQAALELSTSTKPYD 836

Human   845 CVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAEN 909
            |||||||||.||.|||||:.|||...||:....|: .:||:|||||:||||||||||:|:|||||
Mouse   837 CVTASYLLNLLIRQDALPAVLSASSPQQLTRGAGE-TSAVLERNTLVVIKCLMENLEDEISQAEN 900

Human   910 SLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEG 974
            ||||||::|||||||||||.|.|:|.||.|:|.|||||::.:|||:||||||||:||||||||||
Mouse   901 SLLQAASSFPMYGRVHCITRAFQRLPLNDLRLASEWRPLLGRLLLLSYRLSTVVAPVIQSSSPEG 965

Human   975 LIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDTSTEIKGKEV 1039
            |||:||||.||||||:|||||||||||||||..|||||.||||::||:.||.|||:|.|:||||.
Mouse   966 LIPVDTDSASASRLQLILNEIQPRDTNDYFNHTKILKECDSFDLEDLSTSVSNIDSSAEVKGKEE 1030

Human  1040 KTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHLLQSR 1104
            |.|||||||||.||||||||||||||.||||||:||.||||:..|||:|||||||||||||||||
Mouse  1031 KACDVTAQMVLACCWRSMKEVALLLGTLCQLLPVQPGPESSNVFLTVQQVKEIGDYFKQHLLQSR 1095

Human  1105 HRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQ 1169
            |||||||||||||||||:||||.||||||||||||.|||||||.|||||||||||||||||||||
Mouse  1096 HRGAFELAYTGFVKLTEILNRCSNVSLQKLPEQWLRSVLEEIKGSDPSSKLCATRRSAGIPFYIQ 1160

Human  1170 ALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADG 1234
            |||||||||.|||||||||:||||||...||.:..||||||||||||||||||||||||||||.|
Mouse  1161 ALLASEPKKSRMDLLKITMRELISLALSADDSKGRVPQVHALNILRALFRDTRLGENIIPYVAGG 1225

Human  1235 AKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQ 1299
            ||||||||||||||||||||||||:||||:|||||.|||.|||||||||||||||||||||||||
Mouse  1226 AKAAILGFTSPVWAVRNSSTLLFSSLITRVFGVKRGKDEVSKTNRMTGREFFSRFPELYPFLLKQ 1290

Human  1300 LETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSRE 1364
            |||||:||||::|||:|||.||||||||||||.|||||||||||:.||||||:|||.||:|.|||
Mouse  1291 LETVASTVDSELGEPDRHPGMFLLLLVLERLYPSPMDGTSSALSLAPFVPFIIRCGRSPIYRSRE 1355

Human  1365 MAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAY-SDSKHGTNSDF 1428
            |||||||||:|||.||:|:..||::||:.|||||||||||||||||||||||| :|.:|.||:||
Mouse  1356 MAARALVPFIMIDQIPSTLCALLNSLPNSTDQCFRQNHIHGTLLQVFHLLQAYITDCRHRTNADF 1420

Human  1429 QHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGI 1493
            ..||:|:|.|||||||||.||||||||||||||||||||.||:|..:..|..||||||||:||.|
Mouse  1421 LQELSDVTACTKAKLWLAMRQNPCLVTRAVYIDILFLLTNCLDRPEEGKQTALESLGFWEDVRRI 1485

Human  1494 ISGSELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRS 1558
            |..||||.||||.||||||||||||||:|||..|||:.|::..:.|.||:|||:||:|:|||||.
Mouse  1486 ILESELIKGFPWTFKVPGLPQYLQSLTKLAIPEVWASLAEAKGQATAVPLSFSRLLKSSFPEVRL 1550

Human  1559 LTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQT 1623
            |.|:.|||:  |.:|...:|...||||:|||:.|||||||:||.|||::||||:.::|.||||||
Mouse  1551 LALDTLLER--ARSSEQEQKEPLPLLCSMGEELLLLAMKEDHPGCFCRVLKILYHLNPSEWLPQT 1613

Human  1624 EHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAAELKQWVQLVIL 1688
            |...||:|||||:|:||||||:|||||.|||:||||:|::.:|:|.:|::.:|.||:||||||:.
Mouse  1614 ECYAHLSPKEFLMWSMDIASNDRSEIQGVALKLASKIIAYRVQSCEKNKDSLAPELRQWVQLVVW 1678

Human  1689 SCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVT 1753
            ||.|||||.|||||.||||||.|||||:|.||||||.||:||:|||||||||||.||:||||.||
Mouse  1679 SCGDHLPTASRLAVAEVLTSTAPLFLTSPQPILELQGTLSLWRCVLTLLQSEEQTVREAATEIVT 1743

Human  1754 TAMSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLVACVE 1818
            |||||.|||||||||||||||||||.||||||||||||||||.|||||||||||.|.|||...|:
Mouse  1744 TAMSQGNTCQSTEFAFCQVDASIALTLALAVLCDLLQQWDQLEPGLPILLGWLLEEGDDLEGHVQ 1808

Human  1819 SMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSKSGWRPPSPEMLCHLQRMVSEQCHLLS 1883
            |.||.||:::|||:|||||||||.|||.||:.||.||.:|||:.|..:.||||||:.|||.||:|
Mouse  1809 SPHQGEEEHIFEKSEVNFWAETLTFVKSLCRQLFHLLCQSGWQSPHSQKLCHLQRIASEQSHLIS 1873

Human  1884 QFFRELPPAAEFVKTVEFTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLPR 1948
            |.|||||.:|||:||||:||||||||||||.|||||.||||||     |...|...|.||:..||
Mouse  1874 QLFRELPLSAEFLKTVEYTRLRIQEERTLAVLRLLACLEGKEG-----LRAEDCPREWRQVMAPR 1933

Human  1949 TEAAC 1953
            |||||
Mouse  1934 TEAAC 1938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THADA	NP_001077422.1	DUF2428	952..1247	CDD:287339	254/294 (86%)
Thada	NP_898842.2	DUF2428	953..1239	CDD:370999	246/285 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972239
Domainoid	1	1.000	1505	1.000	Domainoid score	I652
eggNOG	1	0.900	-	-		E1_COG5543
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75175
Inparanoid	1	1.050	3029	1.000	Inparanoid score	I601
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40512
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002253
OrthoInspector	1	1.000	-	-		oto117125
orthoMCL	1	0.900	-	-		OOG6_102243
Panther	1	1.100	-	-	LDO	PTHR14387
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2730
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.260