|
Human 1 MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLL--- 62
|.:|||||::|..|......::.||.|.|.:.:|:.:|||.||||.|||.|||.||||||:|
Frog 1 MVLKKKKELKVDVLVFDGPSIQRLKDFVDEKEQNVPALLLQCVQLQDGVQQIHCIKQIVPILGSL 65
Human 63 -EKADKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEEL 126
|.:...|| :.:|||:|:.:|.||:.||||||||||||||:||.:.|:|:..||..|.|::
Frog 66 PEDSTNAGM----VCACLDVLSEMYFSLNSKNPLKKVLASSLNSVPDQYKPDAVSAFTRCLAEDI 126
Human 127 NTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKCAGNHIIQTQLM 191
.|.|...||||.|:::||||||:||.:.|.:|....|.||::.|.....:|::..||.:.||||:
Frog 127 ATEDPEQYRKVVDDLASCMENFSLGSSCVTSLFLEALQFLERVLRMFQSQNKRILGNGLAQTQLI 191
Human 192 NDLLVGIRVSMMLVQKVQD-FQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAI 255
:|||..:::||:||||||| .|..|...|.:|:|:.:|.||..|..::.|:||||.||.|||:|:
Frog 192 HDLLTAVKLSMILVQKVQDPIQTALQSCSAAPLWRTLCDLLGRFADLVMDEDLLQNVQCTSGMAV 256
Human 256 ILFIKTMFHPSEKIPHLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDW 320
:|::|||.|.|.|:|.|:|:|:|.:||....|:||:|.||..|. |:..:|::||.||.||||:|
Frog 257 VLYLKTMLHDSSKLPKLVSNVILCTVDPVDTPDWFLSCCRRFCM-DLPDTALIFLGQGALAMLEW 320
Human 321 QNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGN 385
::||||...|.||||...||...||::||.:..|.|||:||.||.||:::|...|..|.|.|||.
Frog 321 KDGSMGEGSEKLLLDLLDVLLFQSSRLKESSAAMLLSRVLALWTGSALELLTICSTGLKDKLNGR 385
Human 386 SSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWH 450
||.:.::|||||.||||||||:|||||::||||||:||.:|..:| .|||..|||.|||.||||
Frog 386 SSAMQKILEYVYVHWEHPLDAVRHQTKLIFKNLLQIHRKSVALSD--EDPFLSELTHSLLHLEWH 448
Human 451 IKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAE 515
.||||..|||||||:|.|.|||:|.|||||||.||||||..||||:|||.||.|||:.|.|::..
Frog 449 SKGKYASLGCLVECVGTEQILAVDGTIPSQILNVMGDQSFAPYASNLLEAMFINHKNQLTSRSGG 513
Human 516 SSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQ 580
..|.::||:.||.|||..|||.|::|.:|:|||||||||..:||||.:|:::||.| |.|
Frog 514 QCWTERWHDIWVKPLLLRLCEENINQTTYIIDYYLPKLLKCNPESLSFMIEVLQAS--AST---- 572
Human 581 SFPSLGSCNSRGALGALMACLRIARAHGHLQSATD-TWENLVSDARIKQGLIHQHCQVRIDTLGL 644
:|||.:|||:|||:|||||.|||||||:...: .|...||...|:|||:|:|.|||:|.|||
Frog 573 ---NLGSGSSRGSLGAIMACLRTARAHGHLRFTENYVWSGKVSTTLIQQGLVHKHDQVRVDALGL 634
Human 645 LCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSK 709
||||:.|||:||::||:.:.|.:.||||.|||.:|||:|.:||||||||.||||||||.||:|..
Frog 635 LCESHWSTEVVSLDEMKLVLFCLQYNLNCQSPSIRQQLCYMLKKLFCRIHESSQVLYKQEQTKKL 699
Human 710 REPENELTKQHPSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIY 774
...::.......|::||||:.||:|:.|||||:||.|||:.||||||||||:|||:|.|.||...
Frog 700 NIAKDVRNVGDSSLALQQYQEFMASVTNSLFESLFAGSSHPTRFSALTILGAIAEIFPVEEGSCQ 764
Human 775 TVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELSTS 839
:|:.|...:.....|.|:||.::|||:||:|||.||.||:...:..:||.:|..|.|||::||||
Frog 765 SVFHLGPAVQAQHVQALLECLSNTFEEVKVLAFVLLRKLTPCVLVSKDSARLHLLLQAAMDLSTS 829
Human 840 TKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQ---VAC--DNGDRPAAVVERNTLMVIKCLMEN 899
||.:||||||||||||:.|:|||.:|.|....| |.| .|.:| ...||||....::.||..
Frog 830 TKHFDCVTASYLLNFLMCQEALPVALDALDQNQPGPVVCWSRNTER-VNFVERNAFSAVRYLMNK 893
Human 900 LEEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVS 964
|..|:.|||.|||||||:||:|||||||.|.||:|.|..|.:|:|||.::.:|||||||||.:||
Frog 894 LGVEIVQAEMSLLQAAASFPLYGRVHCIIGLLQQLPLKELSMVAEWRDLIGELLLMSYRLSAIVS 958
Human 965 PVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNID 1029
||:.|||||||:|||||:|:|::|.||::|||||||||||:|.:.|: |||::..:..|
Frog 959 PVVHSSSPEGLMPMDTDTEAAAQLHMIMSEIQPRDTNDYFSQPRTLQ-------KDLHSQPLPED 1016
Human 1030 TS------TEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQ 1088
|: ||:||.|..:|.|||||||||||||||||:||||||||.||:...|:|..||:||||
Frog 1017 TAPANSLCTEMKGSEGSSCSVTAQMVLVCCWRSMKEVSLLLGMLCQNLPLMTEPDSPRGLITVEQ 1081
Human 1089 VKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSS 1153
|||:|:|||.|||||||||||||||.||.||||:|..|...||::||.|||.|||||||.|||||
Frog 1082 VKEMGEYFKHHLLQSRHRGAFELAYVGFAKLTEMLIGCKEESLRRLPGQWLCSVLEEIKSSDPSS 1146
Human 1154 KLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDI---QSTVPQVHALNILR 1215
||||||||||||||||||||||||..:...||:|||:|||||.|..|. :||:||||||||||
Frog 1147 KLCATRRSAGIPFYIQALLASEPKNSKAGFLKMTMKQLISLAMPESDASGDKSTIPQVHALNILR 1211
Human 1216 ALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRM 1280
|||||||||||:|||||:|.:|||||||||:||||||||||||.||||||||||.|||.||.|||
Frog 1212 ALFRDTRLGENVIPYVAEGTQAAILGFTSPIWAVRNSSTLLFSTLITRIFGVKRGKDERSKKNRM 1276
Human 1281 TGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMG 1345
||||||||||.||||||:|||.||:||||..||...|||:|||||:|.:||.||||||.|||||.
Frog 1277 TGREFFSRFPALYPFLLEQLEVVADTVDSPTGESKLHPSLFLLLLILSKLYPSPMDGTYSALSMA 1341
Human 1346 PFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQV 1410
||:|||:||||||||.||||||.|||||||.:.:|.|...||::||...|...|||.:|||||||
Frog 1342 PFIPFIIRCGHSPVYRSREMAAHALVPFVMTNEVPQTALNLLNSLPHSADPRIRQNRVHGTLLQV 1406
Human 1411 FHLLQAYSDSKHGTNSD-FQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSA 1474
|:|||::.::||..||: .|.|:.||..|.||:|||||.|||||||||.:|.||.::.
Frog 1407 FYLLQSFFEAKHSANSERIQREMGDIMACMKARLWLAKSQNPCLVTRASFISILEMII------- 1464
Human 1475 KDNQPVL---ESLGFWEEVRGIISG--SELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKS 1534
:||.:| |...|:.::..||.. ||:: |.|..:|||.||.||:.|| :.:|....||.
Frog 1465 -NNQEILRNKEFSSFYSDICTIIECDLSEVV---PHASAIPGLVQYAQSMARL-VLSVLTLNAKL 1524
Human 1535 GERETNV--PISFSQLLE----SAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLL 1593
|..:|:. .:..||||| |.|||||.|.||: |:..|....:.....|.:..||.|.
Frog 1525 GGPDTDAGSTVCPSQLLETLLRSDFPEVRLLVLES-----LSKWSDTCAEETRNYLTSKAEKTLF 1584
Human 1594 -LAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIAS--NERSEIQSVALR 1655
:...|.:|||.|::|.:.:.:...|.|.:.:| :...||:.|:..:.:|| :...||||.|||
Frog 1585 EMISVERNPECLCQVLTLYYKIGAEELLLKMKH-LQTEPKDLLVRVLKLASTASHSVEIQSSALR 1648
Human 1656 LASKVISHHMQTCVENRELIAAELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPI 1720
|:|:::| ....:.:|.:.:|||.|..||...|||.|.||.:||..|:|..|.|.|:||...:
Frog 1649 LSSELLS---ALVAKAQEDVGSELKHWAALVGQFCEDELQTEVKLAAAEMLIKTAPCFVTNQVLV 1710
Human 1721 LELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEFAFCQVDASIALALALAVL 1785
|.|.|||:||..:..|||||:.:|||||.:.:....::|:....|.|.:|.|:..:||.|||..|
Frog 1711 LGLADTLSLWMGIFQLLQSEDISVRDAAADIIRVYHARESHKSETVFPYCTVNPPMALDLALQAL 1775
Human 1786 CDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKH 1850
|.|||||||:..|:||||.||||:.||.::.:|:|..||||:||||.|.|||||.|:||:.|.||
Frog 1776 CGLLQQWDQVPAGIPILLQWLLGDDDDDLSDLETMRLVEEDFLFEKGEANFWAEKLMFVRLLSKH 1840
Human 1851 LFCLLSKSGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVEFTRLRIQEERTLACL 1915
|..|::.:....|..|.|..|....:::...:.:|.:.|||..||:||.|::||.|::|||..|:
Frog 1841 LKDLITSAPSSLPPKENLSELSSAATKRSETIQRFLQALPPTPEFLKTTEYSRLLIEKERTSRCI 1905
Human 1916 RLLAFLE 1922
:|||||:
Frog 1906 QLLAFLQ 1912
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