Protein Alignment SDHA and SDH9

DIOPT Version :10

• Sequence 1: XP_011512374.1
• Gene: SDHA / 6389
• HGNCID: 10680
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_012490.1
• Gene: SDH9 / 853405
• SGDID: S000003581
• Length: 634
• Species: Saccharomyces cerevisiae
• Alignment Length: 579
• Identity: 390/579 - (67%)
• Similarity: 462/579 - (79%)
• Gaps: 19/579 - (3%)

Human    53 AQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEED 117
            |:|.::|||:|.||||||||||||||||:|||:.|||::|||||||||||||||||||||||..|
Yeast    38 AKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYKTACLSKLFPTRSHTVAAQGGINAALGNMHPD 102

Human   118 NWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGK 182
            :|:.|.||||||||||||||||||||.:||.:|:|||:|||||||||||:||||||||||..|||
Yeast   103 DWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVIELEHYGMPFSRTEDGRIYQRAFGGQSKDFGK 167

Human   183 GGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRI 247
            ||||:|.|.|||||||::||||||::|:.:|.:|:||||:|||..|||..||||...|||:|||.
Yeast   168 GGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFFIEYFAMDLLTHNGEVVGVIAYNQEDGTIHRF 232

Human   248 RAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCR 312
            ||..||:|||||||.|||||||||.||||.||::|||.|.:|||||||||:||||:|||||||.|
Yeast   233 RAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLEDLEFVQFHPSGIYGSGCLITEGAR 297

Human   313 GEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLA 377
            ||||.|:||:||||||||||.||||||||||||::|:|||.|||.|..|||:.|||.|||||.|.
Yeast   298 GEGGFLLNSEGERFMERYAPTAKDLASRDVVSRAITMEIRAGRGVGKNKDHILLQLSHLPPEVLK 362

Human   378 TRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLR--HVNGQDQIVPGLYACGE 440
            .|||||||||.:|||||||:||||||||||||||||||.:.|:.|.  ...|:|:::|||.||||
Yeast   363 ERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMGGIPTKWTGEALTIDEETGEDKVIPGLMACGE 427

Human   441 AACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGS 505
            |||.||||||||||||||||||||||.|.:|.::.:||....|:..|.|.||:.||||:|.|.||
Yeast   428 AACVSVHGANRLGANSLLDLVVFGRAVANTIADTLQPGLPHKPLASNIGHESIANLDKVRNARGS 492

Human   506 IRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQN 570
            ::||::||:||::||...:|||....|.||...|:::....:.:...|:.|:||:||||||||||
Yeast   493 LKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNITEVDKTFEDVHVSDKSMIWNSDLVETLELQN 557

Human   571 LMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSY 629
            |:.||.||...|..|||||||||||||..|.|                 .:|||||||:
Yeast   558 LLTCATQTAVSASKRKESRGAHAREDYAKRDD-----------------VNWRKHTLSW 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDHA	XP_011512374.1	FAD_binding_2	40..636	CDD:481218	390/579 (67%)
SDH9	NP_012490.1	FAD_binding_2	5..634	CDD:481218	390/579 (67%)