Protein Alignment SDHA and SdhA

DIOPT Version :10

• Sequence 1: XP_011512374.1
• Gene: SDHA / 6389
• HGNCID: 10680
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_477210.1
• Gene: SdhA / 37228
• FlyBaseID: FBgn0261439
• Length: 661
• Species: Drosophila melanogaster
• Alignment Length: 640
• Identity: 475/640 - (74%)
• Similarity: 539/640 - (84%)
• Gaps: 6/640 - (0%)

Human     1 MSGVRGLSRLLSARRLA-LAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDA 64
            |||:..:..:|:...:| :.:|....:|   |.:|.| .|.::|||...|.||.|||||||.:||
  Fly     1 MSGIMRVPSILAKNAVASMQRAAAVGVQ---RSYHIT-HGRQQASAANPDKISKQYPVVDHAYDA 61

Human    65 VVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKG 129
            :|||||||||||||||...||.||.:||||||||||:||||||||||||||||:|:||.||||||
  Fly    62 IVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKG 126

Human   130 SDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVAD 194
            ||||||||||||||.:||.||:||||||||||||:||||||||||||||||||||||||||.|||
  Fly   127 SDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVAD 191

Human   195 RTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGY 259
            ||||||||||||:||.||.:||||||||||:.|:||||||:||.:|||::||.||||||:|||||
  Fly   192 RTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGY 256

Human   260 GRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGE 324
            ||.:||||||||.|||||||:.|.|||.|||||||||||||||||||||||||||||.|||..||
  Fly   257 GRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGE 321

Human   325 RFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMI 389
            ||||||||||||||||||||||||:||.||||.||||||||||||||||:|||.|||||||||||
  Fly   322 RFMERYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMI 386

Human   390 FAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLR-HVNGQDQIVPGLYACGEAACASVHGANRLG 453
            |||||||:|||||||||||||||:||||:|||:. ..:|:|.|||||||.||||.:|||||||||
  Fly   387 FAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLG 451

Human   454 ANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKS 518
            |||||||||||||||.:|.|..:||...|.:|.||||.||.||||||.|:|.|.|::|||.|||:
  Fly   452 ANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKT 516

Human   519 MQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAE 583
            ||:||||||.|.:||:|..|:.::|...|.:|..||.::||:|||||||||||:..|..||..||
  Fly   517 MQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAE 581

Human   584 ARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKCT 638
            |||||||||||||:|||.||||:|||:.||||||.::||||||||:|....|..|
  Fly   582 ARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDIT 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDHA	XP_011512374.1	FAD_binding_2	40..636	CDD:481218	462/596 (78%)
SdhA	NP_477210.1	PTZ00139	49..661	CDD:240286	459/588 (78%)