Protein Alignment SDHA and sdh1

DIOPT Version :10

• Sequence 1: XP_011512374.1
• Gene: SDHA / 6389
• HGNCID: 10680
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_594319.1
• Gene: sdh1 / 2541690
• PomBaseID: SPAC1556.02C
• Length: 641
• Species: Schizosaccharomyces pombe
• Alignment Length: 668
• Identity: 428/668 - (64%)
• Similarity: 512/668 - (76%)
• Gaps: 47/668 - (7%)

Human    16 LALAKAWPTVLQTGTRGFHFTVDGNKRASA-------KVSDSISAQYPVVDHEFDAVVVGAGGAG 73
            |...|..|::...|......|....|:.::       :||.|.|.:|||:||.:||:||||||||
pombe     2 LRFRKVAPSLKNGGNLKLFSTSSTLKKIASSQPLRAKQVSTSESVKYPVIDHTYDAIVVGAGGAG 66

Human    74 LRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDA 138
            |||.|||:||||||||:||||||||||||||||||||||||.:|:||||||||||||||||||||
pombe    67 LRATFGLAEAGFNTACITKLFPTRSHTVAAQGGINAALGNMTKDDWRWHFYDTVKGSDWLGDQDA 131

Human   139 IHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHT 203
            |||||::||.||:|||::|:|||||::|||||||||||||::||||||:||..||||||||:|||
pombe   132 IHYMTKEAPKAVLELEHFGVPFSRTKEGKIYQRAFGGQSLEYGKGGQAYRCAAVADRTGHSILHT 196

Human   204 LYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFSCTS 268
            |||:||:::|::|:||||:||:||.||||||||:.:|||||||.||..|::|||||||.||||||
pombe   197 LYGQSLKHNTNFFIEYFAMDLIMEGGECRGVIAMNLEDGSIHRFRAHKTILATGGYGRAYFSCTS 261

Human   269 AHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPV 333
            |||.||||.||::|||||.|||||||||||||||||||||||||||||.|:||:||||||||||.
pombe   262 AHTCTGDGNAMVSRAGLPLQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLLNSKGERFMERYAPT 326

Human   334 AKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKE 398
            ||||||||||||:||:|||||||.||||||.||||.|||.|.|..|||||||||.||||||||||
pombe   327 AKDLASRDVVSRAMTVEIREGRGVGPEKDHCYLQLSHLPAEILKERLPGISETAAIFAGVDVTKE 391

Human   399 PIPVLPTVHYNMGGIPTNYKGQVLR-HVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVV 462
            |||||||||||||||||.:.|:||. ..||:|:|||||||.|||||.||||.||||||||||:||
pombe   392 PIPVLPTVHYNMGGIPTRFTGEVLTIDENGKDKIVPGLYAAGEAACVSVHGGNRLGANSLLDIVV 456

Human   463 FGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFR 527
            |||||||.|:::..|.....|:..:||.:|:..||::|.:.|...|||:||.|||:||...:|||
pombe   457 FGRACALHIKDTLEPNTPHKPLAADAGLDSLKFLDQIRTSQGPKHTSEIRLDMQKTMQRDVSVFR 521

Human   528 VGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAH 592
            :...||||...|:::.|..|.:...|||::|||||||.|||:||:.||:||...|..||||||||
pombe   522 MEETLQEGVKNIARVDGTYKDIGIRDRGLIWNTDLVEALELRNLLTCAVQTANAALNRKESRGAH 586

Human   593 AREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKCTAREQHITHRKQLCSCDGGL 657
            |||||..|.|                 ::|.||||::            ||.|         |..
pombe   587 AREDYPERDD-----------------KNWIKHTLTW------------QHKT---------GDP 613

Human   658 STRKERTIGARSSLNKSE 675
            .|.|.|.: .|::::::|
pombe   614 VTLKYRAV-TRTTMDENE 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDHA	XP_011512374.1	FAD_binding_2	40..636	CDD:481218	414/603 (69%)
sdh1	NP_594319.1	PTZ00139	29..641	CDD:240286	422/641 (66%)