Protein Alignment SDHA and sdha-1

DIOPT Version :10

• Sequence 1: XP_011512374.1
• Gene: SDHA / 6389
• HGNCID: 10680
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_509446.1
• Gene: sdha-1 / 181108
• WormBaseID: WBGene00015391
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 632
• Identity: 445/632 - (70%)
• Similarity: 510/632 - (80%)
• Gaps: 22/632 - (3%)

Human     6 GLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDHEFDAVVVGAG 70
            ||...::||.::|:.|                   ..:.||.||  .|||.||||.:||||||||
 Worm     8 GLRNTVAARSVSLSAA-------------------NHSDAKRSD--IAQYKVVDHAYDAVVVGAG 51

Human    71 GAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGD 135
            |||||||.||:|.|..||.:||||||||||||||||||||||||..|||||||||||||||||||
 Worm    52 GAGLRAAMGLAEGGLKTAVITKLFPTRSHTVAAQGGINAALGNMNPDNWRWHFYDTVKGSDWLGD 116

Human   136 QDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSL 200
            ||||||||.:|..||:||||||||||||.|||||||||||||..||:||||||.|||||||||||
 Worm   117 QDAIHYMTREAERAVIELENYGMPFSRTTDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSL 181

Human   201 LHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVVATGGYGRTYFS 265
            ||||||.||:|:.:||||||||||:||||.|.||||:.:|||:|||.|:||||:|||||||.:||
 Worm   182 LHTLYGASLQYNCNYFVEYFALDLIMENGVCVGVIAMDLEDGTIHRFRSKNTVLATGGYGRAFFS 246

Human   266 CTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERY 330
            ||||||.||||||:..|||:...|:||||||||||||||||||||.|||||.|:||.||||||||
 Worm   247 CTSAHTCTGDGTALTARAGINNSDMEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSAGERFMERY 311

Human   331 APVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDV 395
            ||.|||||||||||||||:||.||||.||:|||:||||||||.|||..|||||||||||||||||
 Worm   312 APNAKDLASRDVVSRSMTVEIMEGRGVGPDKDHIYLQLHHLPAEQLQQRLPGISETAMIFAGVDV 376

Human   396 TKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQ-DQIVPGLYACGEAACASVHGANRLGANSLLD 459
            |||||||:|||||||||:|||||||||.:...: |::||||||.||....|||||||||||||||
 Worm   377 TKEPIPVIPTVHYNMGGVPTNYKGQVLNYTPKKGDEVVPGLYAAGECGAHSVHGANRLGANSLLD 441

Human   460 LVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAA 524
            ||:||||||:.|.::...|..||.:..||||.||.|:||||...|.|.|:||||:||||||||||
 Worm   442 LVIFGRACAIDILKNTSAGVGVPELPKNAGEASVANIDKLRHNKGDISTAELRLTMQKSMQNHAA 506

Human   525 VFRVGSVLQEGCGKISKLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESR 589
            |||.|.:|:||...:||||.|..||...|:|:|||:||:||||||||::.|.|||..||.|:|||
 Worm   507 VFRRGDILKEGVKVLSKLYKDQAHLNVADKGLVWNSDLIETLELQNLLINATQTIVAAENREESR 571

Human   590 GAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGK 636
            |||||:|:..|:||.|||||::||.||..::|||||::...::.||:
 Worm   572 GAHARDDFPDRLDELDYSKPLEGQTKKELKDHWRKHSIIRSNIETGE 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDHA	XP_011512374.1	FAD_binding_2	40..636	CDD:481218	438/596 (73%)
sdha-1	NP_509446.1	FAD_binding_2	36..646	CDD:481218	433/583 (74%)