Protein Alignment SDHA and sdha-2

DIOPT Version :10

• Sequence 1: XP_011512374.1
• Gene: SDHA / 6389
• HGNCID: 10680
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_492798.1
• Gene: sdha-2 / 172968
• WormBaseID: WBGene00016392
• Length: 640
• Species: Caenorhabditis elegans
• Alignment Length: 639
• Identity: 436/639 - (68%)
• Similarity: 503/639 - (78%)
• Gaps: 24/639 - (3%)

Human    42 RASAKVSDSISAQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGG 106
            |...|...|.:..:.||||.||||||||||||||||.||||.|..||.:||||||||||||||||
 Worm    16 RTYMKKQVSATTNFDVVDHTFDAVVVGAGGAGLRAAMGLSEGGMKTAVITKLFPTRSHTVAAQGG 80

Human   107 INAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQR 171
            :|||||||..|||||||||||||||||||||||||||.:|..|::||||||||||||.|||||||
 Worm    81 VNAALGNMNPDNWRWHFYDTVKGSDWLGDQDAIHYMTREAERAIIELENYGMPFSRTTDGKIYQR 145

Human   172 AFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIA 236
            ||||||..||:||||||.|||||||||||||||||.||:||.:||||||||||:|:.|:|.||:|
 Worm   146 AFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQYDCNYFVEYFALDLIMDKGKCIGVVA 210

Human   237 LCIEDGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGIY 301
            |.||.|.|||.||||||:|||||||.|||||||||.||||||:..|||:...|:|||||||||||
 Worm   211 LDIETGQIHRFRAKNTVLATGGYGRAYFSCTSAHTCTGDGTALTARAGIRNSDMEFVQFHPTGIY 275

Human   302 GAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYL 366
            |.|||||||.|||||.|:|||||||||||||.||||||||||||:||:||.||||.||.|||:||
 Worm   276 GVGCLITEGSRGEGGYLVNSQGERFMERYAPNAKDLASRDVVSRAMTMEINEGRGVGPNKDHIYL 340

Human   367 QLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHV-NGQDQ 430
            ||||||.|||..|||||||||.||||||||||||||:|||||||||:|||||||||... .|.|:
 Worm   341 QLHHLPAEQLQQRLPGISETAQIFAGVDVTKEPIPVIPTVHYNMGGVPTNYKGQVLDFTPEGGDK 405

Human   431 IVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDKVPPIKPNAGEESVMN 495
            ::|||||.||.|..|||||||||||||||||:|||:|||:|....:|||.:|.:..|..|:|..|
 Worm   406 VIPGLYAAGECAAHSVHGANRLGANSLLDLVIFGRSCALTILNENKPGDSIPELPVNCEEKSCDN 470

Human   496 LDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKISKLYGDLKHLKT-FDRGMVWN 559
            |:.|..:.|.|.:.|||..||.:||.||||||.|.:|:||..|:|.:|.:.::||. .|.|.|||
 Worm   471 LNGLLHSKGDISSIELRQKMQMTMQKHAAVFRRGDLLKEGVDKMSSIYKEQQNLKACADSGKVWN 535

Human   560 TDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRIDEYDYSKPIQGQQKKPFEEHWRK 624
            ::||||||||||::.|.|||..||.|.||||||||:|::.||||||||.|::|||||||::||||
 Worm   536 SELVETLELQNLLINANQTIVAAENRTESRGAHARDDFQERIDEYDYSNPLEGQQKKPFDQHWRK 600

Human   625 HTLSYVDVGTGKCTAREQHITHRKQLCSCDGGLSTRKERTIGARSSLNKSESHY 678
            |::..:|..||..     .:|:|..:           ::|      |:|||:.:
 Worm   601 HSIIGIDTKTGAV-----DLTYRPVI-----------DKT------LDKSETDW 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SDHA	XP_011512374.1	FAD_binding_2	40..636	CDD:481218	428/595 (72%)
sdha-2	NP_492798.1	FAD_binding_2	5..640	CDD:481218	436/639 (68%)