DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Xiap and Bruce

DIOPT Version :9

Sequence 1:	XP_006257568.1	Gene:	Xiap / 63879	RGDID:	620692	Length:	536	Species:	Rattus norvegicus
Sequence 2:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	74/305 - (24%)
Similarity:	109/305 - (35%)	Gaps:	69/305 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat   200 MCSEEARLKTFQNWP--DYAHLSPRELASAGLYY---TGIDDQVQCFCCGGKLKNWEPCDRAWSE 259
            |.||..|.:||:.||  ||....|.::|.||.|:   :..:|:..||.|...|..||..|..|||
  Fly   245 MHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSE 309

  Rat   260 HRRHFPNCFFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLYSVNKEQLA 324
            |.||.|.|.||.|...           :|.|.|.....|||:                    ...
  Fly   310 HERHSPLCPFVKGEYT-----------QNVPLSITYATNPAL--------------------PAP 343

  Rat   325 RAGFYALGEGD--KVKCFHCG--GGLTDWKPSEDPWEQHAKWYPG-CKYLLDE------------ 372
            ..||..:...|  .|.|..|.  |.|:.|.........|....|. ..|:.:|
  Fly   344 GLGFDIISNSDYANVLCTSCSQTGELSVWSIERHLKLMHTFHVPTLLNYIFEESFEWARVTAICV 408

  Rat   373 ----KGQEYINNIHLTHSLGESVVRTAEKTPSVTKKIDDTIFQNPMVQ-----EAIRMGFNFKDI 428
                :.:..:|.::...:.|.|.........|....:....|.:...|     ..:|.|.....|
  Fly   409 LPNARARTKVNYVYSAANYGGSGSSNGAGCNSGLNAVSGGKFGSVNAQHITSTSTLRAGVVGSKI 473

  Rat   429 KKTMEEKLQTSGSNYLSLEVLIADLVSAQKDNSQDESSQTSLQKD 473
            ...:..: |:||.  |:|.:::.::|...: ||:   |.||:..|
  Fly   474 VLGVSVR-QSSGE--LALRMVVLNIVEVDR-NSE---SSTSVSND 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xiap	XP_006257568.1	BIR	68..135	CDD:237989
		BIR	202..272	CDD:197595	32/74 (43%)
		BIR	304..370	CDD:197595	12/70 (17%)
		UBA_BIRC4_8	409..458	CDD:270578	11/53 (21%)
		zf-C3HC4_3	485..528	CDD:290631
Bruce	NP_001262460.1	BIR	251..321	CDD:279047	29/69 (42%)
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810