Protein Alignment SCO1 and SCO1

DIOPT Version :10

• Sequence 1: NP_004580.1
• Gene: SCO1 / 6341
• HGNCID: 10603
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_009593.1
• Gene: SCO1 / 852325
• SGDID: S000000241
• Length: 295
• Species: Saccharomyces cerevisiae
• Alignment Length: 271
• Identity: 95/271 - (35%)
• Similarity: 148/271 - (54%)
• Gaps: 29/271 - (10%)

Human    37 ARVLLRQFCARQAEAWRASGRPGYCLGTRPLSTARPP---PPWSQKGPGDSTRPSKPGPVSW--- 95
            |::|.::........|:::|:       :|||  |.|   .|....|      ..:.|.:.:
Yeast    25 AKLLTQRGFFTVTRLWQSNGK-------KPLS--RVPVGGTPIKDNG------KVREGSIEFSTG 74

Human    96 KSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWL 160
            |::|:..|:||||.......|:....:.|.|..|..|||.|||||.|....|...|:|:.||::.
Yeast    75 KAIALFLAVGGALSYFFNREKRRLETQKEAEANRGYGKPSLGGPFHLEDMYGNEFTEKNLLGKFS 139

Human   161 LIYFGFTHCPDVCPEELEKMIQVVDEIDS---ITTLPDLTPLFISIDPERDTKEAIANYVKEFSP 222
            :|||||::|||:||:||:|:...::.:.|   ||    |.||||:.||.||:...:..|:.:|.|
Yeast   140 IIYFGFSNCPDICPDELDKLGLWLNTLSSKYGIT----LQPLFITCDPARDSPAVLKEYLSDFHP 200

Human   223 KLVGLTGTREEVDQVARAYRVYYSPGPK-DEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEI 286
            .::|||||.:||....:.||||:|..|. ...:||:|||:|..||:.|:|:|:|..|:|..:...
Yeast   201 SILGLTGTFDEVKNACKKYRVYFSTPPNVKPGQDYLVDHSIFFYLMDPEGQFVDALGRNYDEKTG 265

Human   287 AASIATHMRPY 297
            ...|..|::.|
Yeast   266 VDKIVEHVKSY 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		7/30 (23%)
		Important for dimerization	118..131		3/12 (25%)
		SCO	136..278	CDD:239266	64/145 (44%)
SCO1	NP_009593.1	SCO	115..257	CDD:239266	64/145 (44%)