Protein Alignment SCO1 and Sco1

DIOPT Version :10

• Sequence 1: NP_004580.1
• Gene: SCO1 / 6341
• HGNCID: 10603
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_001035115.1
• Gene: Sco1 / 52892
• MGIID: 106362
• Length: 284
• Species: Mus musculus
• Alignment Length: 301
• Identity: 210/301 - (69%)
• Similarity: 231/301 - (76%)
• Gaps: 21/301 - (6%)

Human     3 MLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGYCLGTRPL 67
            |..||...|:|....||||..|||   .|..:...|....:.|:              ||.:|..
Mouse     1 MAALVRAAVVRSQCRQLWRLFPRG---HGLRDVAERPRPEEACS--------------CLRSRAF 48

Human    68 STARPPP---PWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQR 129
            |...|||   |..:.|...|.|| |||||||||||:||||||:||||||:.||||.|||||:|.|
Mouse    49 SAGPPPPGAGPEPKGGQAGSHRP-KPGPVSWKSLALTFAIGGSLLAGMKYFKKEKIEKLEKQRHR 112

Human   130 HIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLP 194
            .|||||||||||||||.||.||||||||||:|||||||||||:|||||||||:||:|||||.:||
Mouse   113 SIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLP 177

Human   195 DLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVD 259
            :||||||:||||||||||||.|||||||||||||||:||:|.|||||||||||||||||||||||
Mouse   178 NLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVD 242

Human   260 HTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKK 300
            ||||||||||||||||||||||:|.|||.|||.|||.:.||
Mouse   243 HTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSHMKK 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		11/30 (37%)
		Important for dimerization	118..131		9/12 (75%)
		SCO	136..278	CDD:239266	127/141 (90%)
Sco1	NP_001035115.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..73		10/27 (37%)
		Important for dimerization. /evidence=ECO:0000250	101..114		9/12 (75%)
		SCO	119..261	CDD:239266	127/141 (90%)