Protein Alignment SCO1 and Scox

DIOPT Version :10

• Sequence 1: NP_004580.1
• Gene: SCO1 / 6341
• HGNCID: 10603
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_608884.1
• Gene: Scox / 33711
• FlyBaseID: FBgn0262467
• Length: 251
• Species: Drosophila melanogaster
• Alignment Length: 226
• Identity: 123/226 - (54%)
• Similarity: 164/226 - (72%)
• Gaps: 9/226 - (3%)

Human    76 WSQK-------GPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGK 133
            |:|:       .|.|||:..  ||:||:|||:..|:|...:..|.:||.||.|...|||||.:||
  Fly    15 WAQQPAIRHYAAPADSTKGK--GPISWRSLAVIGALGAGGVGFMLYVKSEKDEARMKERQRQLGK 77

Human   134 PLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTP 198
            ..:||.:.|....|..:..:|:||:|||||||||||||:||:|||||..||||::.....|.:.|
  Fly    78 AAIGGSWELVDSQGAVRKSEDFLGKWLLIYFGFTHCPDICPDELEKMAAVVDEVEKSPQTPAVQP 142

Human   199 LFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTII 263
            :||::|||||:||.:|.|||||||||:|||||.|::.:|.:|:|||:|.||:|||.|||||||||
  Fly   143 IFITVDPERDSKEVVAKYVKEFSPKLLGLTGTVEQIRKVCKAFRVYFSAGPRDEDNDYIVDHTII 207

Human   264 MYLIGPDGEFLDYFGQNKRKGEIAASIATHM 294
            |||:.|||||:||:|||:.|.:..|||..::
  Fly   208 MYLVNPDGEFVDYYGQNRDKDQCVASILVNI 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		6/21 (29%)
		Important for dimerization	118..131		8/12 (67%)
		SCO	136..278	CDD:239266	88/141 (62%)
Scox	NP_608884.1	SCO1-SenC	81..217	CDD:460630	84/135 (62%)