Protein Alignment SCO1 and sco1

DIOPT Version :10

• Sequence 1: NP_004580.1
• Gene: SCO1 / 6341
• HGNCID: 10603
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_595287.1
• Gene: sco1 / 2539826
• PomBaseID: SPBC119.06
• Length: 263
• Species: Schizosaccharomyces pombe
• Alignment Length: 220
• Identity: 88/220 - (40%)
• Similarity: 143/220 - (65%)
• Gaps: 7/220 - (3%)

Human    85 TRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGER 149
            |..|..|.:|.::|.:..|....|.|..:|.||:..|:...:....||:|.|||.|||..|.|.|
pombe    46 TYQSWRGMISIRALLLAAATSVGLYAYFQHEKKKVLERQNDKVLATIGRPQLGGAFSLIDHHGNR 110

Human   150 KTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLT-PLFISIDPERDTKEAI 213
            .||.|:.|::.|||||||.|||:||:||:||...:|.::::  :.|:. |:||:.||.||..:.:
pombe   111 VTDNDFKGKFSLIYFGFTRCPDICPDELDKMSAAIDIVNNV--VGDVVYPIFITCDPARDPPQEM 173

Human   214 ANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDED---EDYIVDHTIIMYLIGPDGEFLD 275
            |.|:::|:||:|||||:.||:..:.:.:|||:|. ||:.|   :||:|||::..||:.|:|:|::
pombe   174 AEYLEDFNPKIVGLTGSYEEIKDICKKFRVYFST-PKNIDPKKDDYLVDHSVFFYLMDPEGKFIE 237

Human   276 YFGQNKRKGEIAASIATHMRPYRKK 300
            .||:|....::|.:|.::....:|:
pombe   238 VFGRNSTSEDLARAIGSYYLSRKKQ 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		2/5 (40%)
		Important for dimerization	118..131		1/12 (8%)
		SCO	136..278	CDD:239266	67/145 (46%)
sco1	NP_595287.1	SCO	97..240	CDD:239266	67/145 (46%)