Protein Alignment SCO1 and sco-1

DIOPT Version :10

• Sequence 1: NP_004580.1
• Gene: SCO1 / 6341
• HGNCID: 10603
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_494755.1
• Gene: sco-1 / 173763
• WormBaseID: WBGene00015297
• Length: 312
• Species: Caenorhabditis elegans
• Alignment Length: 291
• Identity: 107/291 - (36%)
• Similarity: 165/291 - (56%)
• Gaps: 51/291 - (17%)

Human    61 CLGTRPLSTARPPPPWSQKGPGD--------------------------STRPSKPGPV------ 93
            |..|:|:.|......:|.|..||                          ::.|.:| ||
 Worm    15 CKNTKPVWTLASAARFSDKNKGDDLETDLQKDLKKLNEILKTGITETETTSSPKEP-PVDKNFMN 78

Human    94 ----------------SWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSL 142
                            :||::..|||:||..||.:.::||.:.::.||.|::..||..:||.:.|
 Worm    79 FRKQAEQEAFQRSSIFNWKTVLGTFAVGGTCLAALFYIKKIRLDEREKHRKQTAGKARIGGEWEL 143

Human   143 TTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPER 207
            ....|:.:..::..|.|||:|||||:|||:||:|:|||::||:.|::......:.|:|||:||||
 Worm   144 MNTDGKMEGSQELRGNWLLMYFGFTNCPDICPDEIEKMVKVVEIIEAKKDATPIVPVFISVDPER 208

Human   208 DTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPK--DEDEDYIVDHTIIMYLIGPD 270
            |:...:..|..|||.||.|.|||.|:|::||:.:|||:|.||:  .:::|||||||:|||||.|.
 Worm   209 DSVARVKEYCSEFSNKLRGFTGTTEQVNKVAKTFRVYHSQGPRTNKQEDDYIVDHTVIMYLIDPS 273

Human   271 GEFLDYFGQNKRKGEIAASIATHMRPYRKKS 301
            |:|.||:|||::..|||..|...:..|:.::
 Worm   274 GQFHDYYGQNRKAEEIANVIEMKVLKYQAQN 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		8/53 (15%)
		Important for dimerization	118..131		3/12 (25%)
		SCO	136..278	CDD:239266	71/143 (50%)
sco-1	NP_494755.1	SCO1-SenC	138..276	CDD:460630	68/137 (50%)