Protein Alignment SCO1 and sco1

DIOPT Version :10

• Sequence 1: NP_004580.1
• Gene: SCO1 / 6341
• HGNCID: 10603
• Length: 301
• Species: Homo sapiens
• Sequence 2: XP_031750222.1
• Gene: sco1 / 100494754
• XenbaseID: XB-GENE-6084257
• Length: 278
• Species: Xenopus tropicalis
• Alignment Length: 304
• Identity: 185/304 - (60%)
• Similarity: 227/304 - (74%)
• Gaps: 29/304 - (9%)

Human     1 MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWG---PAEGTARVLLRQFCARQAEAWRASGRPGYCL 62
            ||.|:.:.|||  .:|.      .||...||   ||.......|...|.|.:.
 Frog     1 MAALIGLYGRV--GMGS------ARGAALWGLAAPARNGTGSYLCAVCCRNSR------------ 45

Human    63 GTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKER 127
            ..|.|||..|||      ||..|.|||||||||||||:|.|:||||:||||::||||.:|||:||
 Frog    46 NIRLLSTLPPPP------PGKKTGPSKPGPVSWKSLALTVALGGALMAGMKYLKKEKEDKLEQER 104

Human   128 QRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITT 192
            :|.:|||||||||||..|.|:.||||||||||:|:|||||||||:||||:||||.||||||.|.|
 Frog   105 KRSLGKPLLGGPFSLIDHNGQPKTDKDYLGQWVLLYFGFTHCPDICPEEIEKMILVVDEIDKIPT 169

Human   193 LPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYI 257
            ||:||||||:||||||:|:|:|||||||||||:||||:.|::::||:|||||:|.||||||.|||
 Frog   170 LPNLTPLFITIDPERDSKDAVANYVKEFSPKLIGLTGSSEQIEKVAKAYRVYFSSGPKDEDNDYI 234

Human   258 VDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKS 301
            |||||||||:.|||.|:||:|||||..||::|||:|||.:::::
 Frog   235 VDHTIIMYLLAPDGSFVDYYGQNKRNAEISSSIASHMRNFKQRT 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		13/27 (48%)
		Important for dimerization	118..131		8/12 (67%)
		SCO	136..278	CDD:239266	109/141 (77%)
sco1	XP_031750222.1	SCO	113..255	CDD:239266	109/141 (77%)