DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CEACAM1 and sma-10

DIOPT Version :9

Sequence 1:	NP_001703.2	Gene:	CEACAM1 / 634	HGNCID:	1814	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	110/544 - (20%)
Similarity:	180/544 - (33%)	Gaps:	185/544 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    34 AQLTTESMPFNVAEGKEVLLLVHN----LPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPA 94
            |.|...||||     ...|...:|    :|::.|       ||..        |:.....|..|.
Worm   383 AVLYNTSMPF-----LRSLRFTNNQLRVIPKRAF-------ERFP--------ALEELDLTDNPI 427

Human    95 NSGRETIYPNA--SLLIQNVTQNDTG-------------FYTLQVIKSDLVNEEA---------- 134
                .||:|.|  .|.::.:..|.:.             .|.|::.||.::.:.:
Worm   428 ----ATIHPEAFEPLELKRLVMNSSSILCDCQISWLASWIYRLKLDKSSIIAKCSYPPPLADLYV 488

Human   135 ----TGQFHVYPELPKPSISSNNSNPVEDKDAVA----FTCEPETQDTTYLWW---INNQSLPVS 188
                |.....:.:.|:..|.   ..|||....:.    |||.........:.|   .|.|
Worm   489 VAIDTANLTCHNDSPRAKIV---RQPVEVSTLIGEKARFTCNVYGASPLSIEWRVMENGQ----- 545

Human   189 PRLQLSNG------NRT----------------LTLLSVTRNDTGPYECEIQNPVSANRSDPVTL 231
            ||:.:.:.      |||                |.|.:|...|...|:|..:|...::.|..|.|
Worm   546 PRVLVQDSATFLSINRTAVVNGTFDERELAAAELLLDNVAMTDNSEYQCVARNRFGSDFSTHVKL 610

Human   232 NVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQ---------------ST 281
            .|...|.. |.:|.|.....|......|.|...|..:..|    .|:|               :.
Worm   611 QVYQAPKF-TYTPEDMPLLVGQTAKFLCAATGTPRPEIKW----AFEQIPFPAAEARRLYVTPND 670

Human   282 QELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIV---------TELSPVVAKPQIKASKTTV 337
            ..::|.|:|..:.|:|||||.| |.|..:.:...|:.         .:|||::.|
Worm   671 DHIYIMNVTKEDQGAYTCHATN-VAGQTQASANLIVFENFFHYPESPDLSPMLIK---------- 724

Human   338 TGDKDSVNLTCSTNDTGISIR----WFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEV 398
              .:|::.:.||.:  .||.|    |..:.|.:...::.|.|..:..|::......|:|.|.||:
Worm   725 --KRDALKIDCSCD--LISSRQRMVWKRQQQVILFLKKAKFSDNDQILTLTQTTFSDSGEYSCEL 785

Human   399 FNPISKNQSDPIMLN-------VNYN-------ALPQE-------------------NGL----S 426
            :      ..|.|::.       ||.:       .|.|.                   ||:    |
Worm   786 W------VDDTILMRKITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKSTGNGIYLMAS 844

Human   427 PGAIAGIVIGVVALVALIAVALAC 450
            ..|...:::||:..:.:.....:|
Worm   845 CSAFGLMILGVITSICICIAKCSC 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CEACAM1	NP_001703.2	Ig_CEACAM_D1	36..140	CDD:143251	25/136 (18%)
		Required for homophilic binding. /evidence=ECO:0000250\|UniProtKB:P16573	39..142		24/135 (18%)
		Ig_CEACAM_D4	146..233	CDD:143217	25/115 (22%)
		IG_like	157..233	CDD:214653	23/104 (22%)
		Ig_2	240..318	CDD:290606	23/92 (25%)
		IG_like	244..304	CDD:214653	18/74 (24%)
		I-set	317..408	CDD:254352	20/103 (19%)
		Ig	340..415	CDD:299845	18/85 (21%)
		DUF4690	<419..451	CDD:292384	9/55 (16%)
		Interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:P16573	450..462		1/1 (100%)
		Interaction with FLNA. /evidence=ECO:0000250\|UniProtKB:P16573	452..526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..513
		Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level. /evidence=ECO:0000250\|UniProtKB:P31809	489..526
		Essential for interaction with PTPN11 and PTPN6. /evidence=ECO:0000250\|UniProtKB:P31809	520..523
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		LRR_8	172..231	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380
		LRR_8	243..303	CDD:290566
		leucine-rich repeat	245..268	CDD:275380
		LRR_RI	269..453	CDD:238064	21/93 (23%)
		leucine-rich repeat	269..292	CDD:275380
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	315..373	CDD:290566
		leucine-rich repeat	317..340	CDD:275380
		leucine-rich repeat	341..364	CDD:275380
		leucine-rich repeat	365..392	CDD:275380	4/8 (50%)
		LRR_8	393..450	CDD:290566	15/75 (20%)
		leucine-rich repeat	393..416	CDD:275380	6/37 (16%)
		leucine-rich repeat	417..438	CDD:275380	6/24 (25%)
		I-set	506..612	CDD:254352	25/113 (22%)
		Ig	522..606	CDD:143165	18/88 (20%)
		I-set	616..705	CDD:254352	23/94 (24%)
		Ig	633..705	CDD:299845	18/76 (24%)
		Ig	716..786	CDD:299845	20/83 (24%)
		IG	719..788	CDD:214652	19/88 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910