Protein Alignment SCNN1D and ppk19

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_651708.2
• Gene: ppk19 / 43489
• FlyBaseID: FBgn0039679
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 113/607 - (18%)
• Similarity: 201/607 - (33%)
• Gaps: 211/607 - (34%)

Human   193 PRPGPPSAPPPPPKEGHQEGLVEL-----PASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSW 252
            |||.|              ||:..     ...|||.|.....::.||| ::.|....:..:...|
  Fly    11 PRPRP--------------GLLRFRNNPRGIKFREKLCNSFAHSNIHG-MQHVFGEQHLWQRCLW 60

Human   253 GLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKL------LPLVTLCDGN----PRRPSP 307
            ..:.|||::.......:|..||..:   :.||:....:|      .|.|.:|..|    .|.||.
  Fly    61 LAIVLGAVITGFSLYTVLMHRHSEQ---LLVSLIETTQLPVYHIDFPAVAVCPWNHFNWQRAPSA 122

Human   308 VLRHL------ELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSR 366
            .:|.|      ||.:.| |:.:.|:..:|.|                              :.:|
  Fly   123 FIRFLPRHPNAELRETF-RQLLASMDIMNFS------------------------------NFNR 156

Human   367 VRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVL-SCSYD 430
            :|:            ..:...:|::      :....|::..:....::.       ||. ||.:|
  Fly   157 IRI------------LTKRNLTGIS------YLKMTDLMNFMTYRCDEL-------FVADSCVFD 196

Human   431 GLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTL---AGIRVM 492
            .......:.........|.|...:.: .::.....|.:.     :..||  .|||.   :|::..
  Fly   197 ETPYDCCKLFVREQTVKGQCLVFNSM-ISENSRKKHLIN-----QFYPH--KLSTAGEDSGLKFT 253

Human   493 VHG----RNH----TPF---------------LGHHSFSVRPGTEATISIR------EDEVHRLG 528
            ::.    .|:    |||               :.:|.:   |.||..:::.      ....:.:.
  Fly   254 INASYSFMNNIDALTPFGMNLMIKEPRQWSNEMMYHLY---PDTENFVAVHPLVTETSPNTYEMS 315

Human   529 SPYGHCTAGGEGVEVELLHNTS--YTRQACLVSCFQQLMVETCSCGY--YLHPLPAGAE------ 583
            .....|....|  :.....|||  |.|:.|||.|...::.:||.|..  :|.|:....|
  Fly   316 PKKRRCYFDDE--KNPTFQNTSLTYNRENCLVVCLHLVVWKTCQCSLPAFLPPIDGVPECGINDA 378

Human   584 --------------------YCSSARHPAWGH-CFYRLYQDLETHRLPCTSRCPRPCRESAFKLS 627
                                |.:.:|.   || |                 .||..|....:::|
  Fly   379 QCLGNNSDIFTYVKMGDQEKYINDSRQ---GHFC-----------------DCPDNCNSRLYEMS 423

Human   628 TGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAM 692
            ....:....|::       .:|.:..|.:..:..:.||   ..:|.|.:::         ||:..
  Fly   424 LNVRKLDYPKNS-------TDQLIKAQVYYGQRVMTKI---ITKLKYTNID---------LLANF 469

Human   693 GSLCSLWFGASVLSLLELLELL 714
            |.:.||:.||||:|.:|||.:|
  Fly   470 GGIISLYIGASVMSFIELLFVL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		4/17 (24%)
		ENaC	219..784	CDD:273304	107/576 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777
ppk19	NP_651708.2	ASC	37..489	CDD:459966	101/563 (18%)