Protein Alignment SCNN1D and ppk21

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 128/654 - (19%)
• Similarity: 213/654 - (32%)
• Gaps: 224/654 - (34%)

Human   198 PSAPPPPPKE-GHQEGLVELPASFRE-------------LLTFFCTNATIHGAIRLVCSRGNR-- 246
            |.|..|..:: |.:.||::.....|:             .|..:...:::|| ||.:.....|
  Fly     8 PRARRPLYRDYGGKSGLIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHG-IRYLADPKMRNY 71

Human   247 ----------LKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPL------- 294
                      |.||     |:||:|... .|..|::       .:.:....:..:||:
  Fly    72 LNIRVIWLLILLTT-----SIGAIVVYV-DLNELYQ-------TVRIQTTIKNTMLPIFRIPFPS 123

Human   295 VTLCDGNPRRPSPVLRHLELLDEFARENIDSLY------------NVNLSK--------GRAALS 339
            :.||..|  |.:..:...|.:|.|...|:.:..            :.:||:        |...|:
  Fly   124 IGLCPRN--RLNWKILETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHLSRLNEMSNFFGNKTLT 186

Human   340 ATVPRHEPPFHLD-REI------RLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWY 397
            ..:...:   ||| ||:      |.|.|.|:                 |.:||.......|.: |
  Fly   187 DELHMLD---HLDLREVYKFIQFRCQDLFHT-----------------CRWRGNPVNCCEVIE-Y 230

Human   398 HFH-----YVDILALLPAAWEDSHGSQDGHFVLSCSY----DGLDCQARQFRTFHHPTYGSCYTV 453
            .|.     :|....:.||:.:.:.  :|.::.|...:    .|||...|..|:|
  Fly   231 QFTEAGLCFVFNTEISPASRQKAR--EDKYYPLRTPHYGEGSGLDLFLRLNRSF----------- 282

Human   454 DGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATIS 518
                  .||| ..|:.::::..||     .|.:.         .|.|...|...|:.|....|
  Fly   283 ------IRPG-KRGINVMIKQPQQ-----WSDVV---------RHVPHEAHTRISITPRFTVT-- 324

Human   519 IREDEVHRLGSP-YGHCTAGGEGVEVELLH-----NTSYTRQACLVSCFQQLMVETCSCGYYLHP 577
               ||..|..:| ...|..|.   ||:..|     :..|....|...|.|:.::..|.|...:.
  Fly   325 ---DERTRTVTPEIRRCIFGD---EVDNPHYKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIF- 382

Human   578 LPAGAEYCSSARHPAWGHCFY--RLYQDLETH-------RLP--------CTSRCPRPCRESAFK 625
            .|...:...:|...:...|.|  |....:|.|       :.|        |.:.|.:...:..|.
  Fly   383 FPISDKDNFTACKASDFKCLYDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFT 447

Human   626 LST----------GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEA 680
            .:|          ||.|......:||                         .:..:.|.|
  Fly   448 TTTLDNNETDTEAGTMRLDIFYQSGW-------------------------FIQYQTNMR----- 482

Human   681 PVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGA 745
              ::..:||::.|.:..|:.|||:||..||....  :..|.|.:.|:|..|        .|..|.
  Fly   483 --FTFVELLASFGGIIGLFLGASLLSAFELAYYF--SIGLYLYIHGKRKLR--------KPEPGV 535

Human   746 SSIK 749
            .:|:
  Fly   536 LTIQ 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		4/13 (31%)
		ENaC	219..784	CDD:273304	122/632 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777		3/12 (25%)
ppk21	NP_651704.2	ASC	51..513	CDD:459966	112/573 (20%)