Protein Alignment SCNN1D and ppk26

DIOPT Version :9

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 647
• Identity: 116/647 - (17%)
• Similarity: 207/647 - (31%)
• Gaps: 178/647 - (27%)

Human   192 PPRPGPPSAPPPPPKEGHQEGLVELPA----SFRE---------------------------LLT 225
            |..|....|..|||...:|.....|.|    :|||                           ::.
  Fly     8 PHTPSHEVAVRPPPCAANQWKRAALMARMAPAFRETVSDDSEDEVDTKKQIKYGSGFQAAKAIIH 72

Human   226 FFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHW-HRPVLMAVSVHSE- 288
            .:|...|||| ||.:..:...|....:.:..|...|..|.:|.|.....| :.||:::.:..|.
  Fly    73 EYCDYTTIHG-IRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAEKSTP 136

Human   289 --RKLLPLVTLCDGNPRRPSPVLRH--LELLDEF-----ARENIDSLYNVNLSKGRAALSATVPR 344
              :...|.||:|      |....|.  ....|.:     .:.|:..:  |:||..:..|...|.:
  Fly   137 VWQIPFPAVTVC------PETKTRREIFNFTDSYHQVRDFQSNVSGI--VDLSDKQKGLYGAVSQ 193

Human   345 -HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALL 408
             .||..|   ::.|      |::.|.|..:.::             :..|..    |:.|  ..|
  Fly   194 VCEPHLH---DVTL------GNKTRRGMEIIDA-------------LTEVSP----HFDD--TYL 230

Human   409 PAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGV---------------WT 458
            ...|.:|.......|....:.||: |     .:|:..:....:..:|:               |.
  Fly   231 NCKWRNSPVKCSDIFHKFVTEDGV-C-----FSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWN 289

Human   459 AQ-----------------RPGITHGV-----GLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPF 501
            .:                 .||...|:     |..:..:.....|    :.|.::::|.......
  Fly   290 VEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGP----VQGFKILLHTPGDVAQ 350

Human   502 LGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGV--------------EVELLHNTSYT 552
            :....|.:....|..||||...:           ...:|:              |.||.:...|:
  Fly   351 VSKQYFRIPFDQEVLISIRPKII-----------TTSDGLKHYEPNRRQCYFQKERELRYFNIYS 404

Human   553 RQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDL------------- 604
            :..|.:.|.....:..|.|..:..|.......|..|..    .|:.:...:|
  Fly   405 QSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDASL----KCYNQAEDELLLREFTQGLVNAG 465

Human   605 ETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVY 669
            |..|......|...|...|::.....:.:....    .:.|...:|...||.||...:::::|.:
  Fly   466 ENTRGETECNCLPSCTSIAYEAEISQADFDYKT----VINTDSPEGKEEQSKRQGMKMSRVSIFF 526

Human   670 QELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRR 731
            :|..:.:...:.:|.....|:..|.|..|:.|.|:||::||:..     ....::...|:||
  Fly   527 KEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELIYF-----CTVRLISNLRMRR 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		6/18 (33%)
		ENaC	219..784	CDD:273304	107/616 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777
ppk26	NP_648125.3	ASC	74..570	CDD:279230	101/561 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820