Protein Alignment SCNN1D and ppk9

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_611622.2
• Gene: ppk9 / 37498
• FlyBaseID: FBgn0085398
• Length: 599
• Species: Drosophila melanogaster
• Alignment Length: 762
• Identity: 141/762 - (18%)
• Similarity: 230/762 - (30%)
• Gaps: 303/762 - (39%)

Human   105 TSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGA------LTSRS------- 156
            :||.|||...:...:|.|                     |.:..|.|      |||.:
  Fly     8 SSPSAAARTLTSSSSRSS---------------------WAENEGSASGSDSLLTSSTASLLPPQ 51

Human   157 -------PGP---VAPQRPCHLKGWQHRPTQHN----------AACKQGQAAAQTPPRPGPPSA- 200
                   |||   :.|.     .|.:|   |||          |....|.||..   :|||..:
  Fly    52 DNNRRLGPGPGLLIFPG-----TGQRH---QHNPNGSTGSKTIAKANDGNAAIN---QPGPARSI 105

Human   201 -----PP---PPPKEGHQEG------------------LVELPASFRELLTFFCTNATIHGAIRL 239
                 ||   |||::..|:|                  ||:..|...|    |...::|||.|.|
  Fly   106 RSFRRPPLWQPPPQDHAQDGQEMEVLDRQKRKDCRPACLVKGQAFIIE----FLQGSSIHGFIYL 166

Human   240 VCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHR----PVLMAVSVHSERKLL-----PLV 295
            .....:.::...|    |..:....:.:..|.:|.|||    |:::::   ...||:     |.:
  Fly   167 AKLGLSFVERVLW----LAFICVALFSIISLSKRTWHRFQTSPMVISM---DRNKLVWNTSFPSL 224

Human   296 TLCDGNPRRPSPVLRHLELL----DEFARE----------------NIDSLYNVNLSKGRAALSA 340
            |:|   |.:....|:..|.:    |:|..|                ..|:|..:.|:|     |.
  Fly   225 TVC---PHKRIDELKVEEYILAHPDQFLSEEDQEDFRDFIVKLASLTYDNLETLPLNK-----SY 281

Human   341 TVPR-------HEPPFHLDREIRLQRLSHSGSRVRV-------GFRLCNSTGGDCFYRGYTSGVA 391
            .:|.       :|..:..:.||      .||:.|::       .|.:|:|..            :
  Fly   282 GIPSTKYLELLYELKWAFEPEI------SSGAAVKMFIYETQTEFGICHSVN------------S 328

Human   392 AVQDWYHFHYVDILALLPAAWED------SHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSC 450
            .|..:..|.|          |..      .||.                     |...||..|..
  Fly   329 MVARYNSFDY----------WRSGDWSLMDHGD---------------------RVTVHPLDGEI 362

Human   451 YTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEA 515
            |       ||                     :::......|..||....|.:....::.......
  Fly   363 Y-------AQ---------------------IINLSTAYDVYFHGAGDVPSISKQRYTFPESDYT 399

Human   516 TISIREDEV----HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCS------ 570
            |:.:...|:    ....:....|....|.  .|::....|:...||..|.....:..|.
  Fly   400 TVELIALEIFTNEEARATKQRSCRFNYEA--EEMMTVPIYSFGLCLSECRMFFALRVCGCVPHFY 462

Human   571 ---CGYYLHPLPAGAEYCSSARHPAWG----HCFYRLYQDL-----ETHRLPCTSRCPRPCRESA 623
               |||. |..  |.:..:..|.|..|    .|..::.:::     :.:::.|  .|...|.:|.
  Fly   463 RNRCGYN-HIF--GTQMRNGRRLPVCGLEGIGCLVKIKREIISLKSDKYKINC--NCLANCDDSN 522

Human   624 FKLSTGTSR-WPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQ 687
            |.:.:..|| |....:..|.:       |.|...:.|..:                   ::|...
  Fly   523 FFVQSYRSRVWFLGANLQWGI-------LEHPKMQLRREV-------------------LFSFAD 561

Human   688 LLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWF 734
            :|..:|.|...:.|.|.||..|::          .....|.:||.:|
  Fly   562 VLVYIGGLVGFFLGCSALSFTEII----------YYFTARFVRRMFF 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		26/107 (24%)
		ENaC	219..784	CDD:273304	102/588 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777
ppk9	NP_611622.2	ASC	154..587	CDD:459966	97/567 (17%)