Protein Alignment SCNN1D and ppk6

DIOPT Version :10

• Sequence 1: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 120/554 - (21%)
• Similarity: 203/554 - (36%)
• Gaps: 126/554 - (22%)

Human   193 PRPGPP-SAPPPPPKEGHQEGLVE--LPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 254
            |.||.. |......|.|....|:.  :.|:|.|    :.....:.|...:..:|...|....|..
  Fly     8 PTPGKKNSKGDGSRKRGKDPSLIRTAILATFWE----YTERTKVSGMWLMRRNRTYGLSRFIWSS 68

Human   255 LSLGALVALCWQLGLLFERHWHRPVLMAVS--VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDE 317
            :.|..|:...:...||:.:.:..|:|..:|  :.......|.||:|       ||.:.:.|.:|.
  Fly    69 VLLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTIC-------SPKVVNSERVDR 126

Human   318 FARE-NIDSLYNV-NLSKGRAALSA-TVPRHEPPFH-----LDREIRLQRLS--HSGSRVRVGFR 372
            :.:. .|...|:: .:..|...|:| |....|||.|     .|..:||..:|  .:...|..|
  Fly   127 YVKTLKIPKEYDMAEVIAGFDFLNAFTDQSFEPPGHDSYRATDAVLRLNNVSIWEAAMAVSPG-- 189

Human   373 LCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQAR 437
             |......||: |:|. ....|...:..::...|.|......::..::..||
  Fly   190 -CFDYVKRCFW-GHTE-FQCNQSHEYLSFIPTTAYLGPCCSFNYNPRNASFV------------- 238

Human   438 QFRTFHHPTYGSCYTVDGVWTAQRPGITH----------GVGLVLRVEQQPHLPL-LSTLAGIRV 491
                   |...:.:.:||       |:|.          ..||::.|    |.|: ..|.|...|
  Fly   239 -------PFSANIFGMDG-------GLTFVGAEGSERNLNTGLIVLV----HHPMDYVTEAAASV 285

Human   492 MVHGRNHTPFLGHHSF-SVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQA 555
            .:..::       .|| .|.|    |:.....||..|......|...|:      |..::|.:.|
  Fly   286 TITAQS-------ESFVEVSP----TVQSSSVEVLELSERKRDCLISGD------LQLSNYRQAA 333

Human   556 CLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCR 620
            ||::|..:.:|:.|.|..||.|: .|.::.....:..:  |:...|.:.::.|  | .:|...|.
  Fly   334 CLLACQTEAIVKKCGCHPYLLPI-VGNKFKECNLNDTF--CYSANYDNFKSVR--C-DQCLPNCY 392

Human   621 ESAFK-LSTGT---------SRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYR 675
            :..:. ||..|         ||:.|.:.            |.:.|...|..|||..:..
  Fly   393 DVTYSTLSYKTDLNQHKYSVSRFYSPEL------------LNNDSFVLRVYLAKQVVPV------ 439

Human   676 SVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 709
             :.:..|.|...|||.:|.:.:|..|.|::|::|
  Fly   440 -IRKVTVMSWIGLLSDLGGIFNLCLGLSMISVVE 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		6/18 (33%)
		ENaC	219..784	CDD:273304	112/525 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777
ppk6	NP_611461.3	ASC	85..476	CDD:459966	102/473 (22%)